Understanding and Treating Ataxia Telangiectasia (R01) | Apply Online

Opportunity Summary:

The grant opportunity titled Understanding and Treating Ataxia Telangiectasia (R01) (Funding Opportunity Number PA-07-272) is an NIH funding announcement designed to push forward research on Ataxia Telangiectasia (A-T), a complex, multisystem disorder. The focus is broad by design: it supports studies that clarify how A-T symptoms arise and progress over time, builds tools and shared resources that make A-T research easier and faster, and accelerates the development and testing of promising therapies. A central theme of the announcement is moving the field forward through interdisciplinary collaboration, recognizing that A-T spans neurology, cancer biology, immunology, genetics, aging-related mechanisms, cardiopulmonary issues, and more.

Multiple NIH institutes participate, reflecting the cross-cutting nature of A-T. The participating institutes include the National Institute of Neurological Disorders and Stroke (NINDS), National Cancer Institute (NCI), National Heart, Lung, and Blood Institute (NHLBI), National Human Genome Research Institute (NHGRI), National Institute on Aging (NIA), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and Other Communication Disorders (NIDCD), and the National Institute of Environmental Health Sciences (NIEHS). The opportunity is also offered in conjunction with two patient-advocacy and foundation partners, the Ataxia Telangiectasia Childrens Project and the A-T Ease Foundation, signaling an emphasis on meaningful progress toward treatments and practical research infrastructure.

Funding is provided through the NIH R01 mechanism, which is the standard NIH award for full-scale, investigator-initiated research projects. The announcement notes that it runs in parallel with two companion opportunities of the same scientific scope but different grant sizes and development stages: an R21 (PA-07-273) for exploratory or developmental work and an R03 (PA-07-274) for smaller projects. In practice, that means applicants can choose the mechanism that best matches their project maturity, budget needs, and level of preliminary data, while staying aligned with the same overall A-T research goals.

The announcement encourages a wide range of research types, explicitly including basic, translational, and clinical studies. Basic research might address the underlying biology and pathways leading to A-T features, including how disease processes begin and why different organ systems are affected. Translational research may focus on turning mechanistic insights into therapeutic strategies, biomarkers, or intervention targets, while clinical research may involve evaluating candidate therapies, improving clinical management, or developing outcome measures and natural history data that make clinical trials feasible and interpretable. Another highlighted priority is resource development, which can include shared datasets, biobanks, animal or cellular models, or other community tools that help the field move faster than any single lab can alone.

Awards under this FOA depend on the availability of funds and on receiving a sufficient number of high-quality, meritorious applications. The notice does not promise a fixed number of awards; instead, it emphasizes competitiveness and scientific merit under the usual NIH peer-review process. There is no cost sharing or matching requirement, which is typical for NIH research grants and reduces barriers for institutions that might otherwise struggle to provide required match funding.

Eligibility is intentionally broad. Eligible applicants include public and private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses and other for-profit organizations (beyond just small businesses), and a wide range of government entities such as state and local governments, U.S. territories, and tribal governments and organizations (both federally recognized and other categories listed). The announcement also explicitly includes eligibility for foreign (non-U.S.) entities, eligible federal agencies, and faith-based or community-based organizations. It also names categories of institutions often emphasized in federal eligibility language, including Hispanic-serving institutions, historically black colleges and universities, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions. The overall message is that any organization with the capacity to carry out strong A-T research, including international groups, can apply.

From an administrative standpoint, the opportunity is categorized as a discretionary grant from the National Institutes of Health and spans several CFDA program areas, reflecting the participating institutes. It was posted January 4, 2007, and uses multiple receipt dates (applicants are directed to the full announcement for specific cycles and deadlines). The listing shows an archive date of February 2, 2010, indicating it is no longer active as written, but it remains a useful reference point for the NIHs stated priorities and for tracking the evolution of A-T research funding. The full archived announcement is linked through the NIH grants guide, and NIH provides an Office of Extramural Research (OER) webmaster contact for access or technical issues.

In short, PA-07-272 is built to strengthen the entire A-T research pipeline: understanding disease mechanisms, enabling shared research resources, and speeding therapeutic progress, while inviting participation from a wide variety of institutions and disciplines under the established NIH R01 framework.

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