Opportunity Information: Apply for PAS 07 267
Apply for PAS 07 267
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "The Role of Nuclear Receptors in Tissue and Organismal Aging (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.396 Cancer Biology Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Dec 22, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Small businesses Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Private institutions of higher education City or township governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) State governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity titled "The Role of Nuclear Receptors in Tissue and Organismal Aging (R01)" (Funding Opportunity Number PAS-07-267) supports research aimed at explaining how nuclear receptors and related signaling networks shape the biology of aging. The central focus is on uncovering fundamental mechanisms that involve nuclear receptors, their co-regulators, and intracellular signaling systems, and then connecting those mechanisms to the development or progression of disease and functional decline that typically emerge in middle and older age. In practice, the opportunity is meant for projects that move beyond describing age-related changes and instead investigate how nuclear receptor pathways actively influence aging processes across tissues and the whole organism, and how those pathways intersect with age-associated pathophysiology.
This announcement uses the NIH Research Project Grant (R01) mechanism, which is generally intended for more mature, hypothesis-driven research programs with clearly defined aims and an approach that can be executed over a multi-year project period. It is explicitly paired with a parallel announcement of the same scientific scope that uses the R21 mechanism (PAS-06-466), which is often used for earlier-stage, higher-risk exploratory or developmental ideas. Applicants choosing the R01 route should typically be prepared to propose a well-supported research plan, a solid experimental strategy, and outcomes that can meaningfully advance mechanistic understanding in the aging field as it relates to nuclear receptor biology.
Funding under this program is not guaranteed and depends on NIH appropriations and the availability of funds, as well as the volume and quality of applications received. The announcement does not specify a fixed number of awards; instead, it states that awards are contingent upon submitting a sufficient number of meritorious proposals. There is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds to receive support under this FOA.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Academic institutions are eligible, including public/state controlled and private institutions of higher education, as well as minority-serving institutions such as Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. Nonprofit organizations are eligible whether or not they have 501(c)(3) status (as long as they otherwise qualify), and a range of governmental entities may apply, including state governments, county governments, city or township governments, U.S. territories or possessions, special district governments, and independent school districts. The announcement also permits applications from tribal governments (both federally recognized and other than federally recognized) and tribally designated organizations. Small businesses and for-profit organizations (including for-profits other than small businesses) are also included. Importantly, foreign institutions are eligible to apply, and eligible agencies of the federal government may apply as well. Faith-based and community-based organizations are explicitly listed as eligible.
From an administrative standpoint, this opportunity is categorized as a discretionary grant under NIH, with activity and program relevance spanning multiple CFDA areas, including Environmental Health (93.113), Cancer Biology Research (93.396), Diabetes, Digestive, and Kidney Diseases Extramural Research (93.847), and Aging Research (93.866). This reflects the cross-cutting nature of nuclear receptor research, since these receptors are deeply involved in metabolism, inflammation, stress responses, endocrine signaling, and other systems that can influence both lifespan biology and specific chronic diseases common in later life.
Key dates indicate the opportunity was posted on December 22, 2006, and it used multiple receipt dates rather than a single deadline, meaning submissions were accepted on recurring standard NIH due dates during the active period of the announcement. The listing notes an archive date of June 1, 2009, indicating the FOA is no longer active in its original form, but it remains useful as a reference point for the kind of research NIH sought to stimulate at the time. The full announcement was hosted through the NIH Grants Guide at the provided link (http://grants.nih.gov/grants/guide/pa-files/PAS-07-267.html), and applicants or readers who had trouble accessing the announcement were directed to contact the NIH Office of Extramural Research (OER) webmaster via the listed email addresses.
Overall, PAS-07-267 was designed to encourage rigorous, mechanism-focused studies that explain how nuclear receptor signaling and its regulatory partners contribute to tissue-level aging and whole-organism aging, and how those pathways connect aging biology to the onset and progression of diseases that disproportionately affect people in midlife and older adulthood.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "The Role of Nuclear Receptors in Tissue and Organismal Aging (R01)" and its Funding Opportunity Number (FON) is PAS-07-267.
What is the main scientific purpose of PAS-07-267?
This funding opportunity supports research aimed at explaining how nuclear receptors and related signaling networks shape the biology of aging. It emphasizes uncovering fundamental mechanisms involving nuclear receptors, their co-regulators, and intracellular signaling systems, and connecting those mechanisms to disease development/progression and functional decline that typically emerge in middle and older age.
What kind of research approach is NIH looking for under this announcement?
The announcement is geared toward projects that move beyond describing age-related changes. The intent is to support mechanistic studies that investigate how nuclear receptor pathways actively influence aging processes across tissues and the whole organism, and how those pathways intersect with age-associated pathophysiology.
What grant mechanism does this announcement use?
PAS-07-267 uses the NIH Research Project Grant (R01) mechanism.
What does the R01 mechanism imply about the type of project NIH expects?
Because this uses an R01 mechanism, it is generally intended for more mature, hypothesis-driven research programs with clearly defined aims and an approach that can be carried out over a multi-year project period. Applicants are expected to propose a well-supported research plan, a solid experimental strategy, and outcomes that can meaningfully advance mechanistic understanding of aging as it relates to nuclear receptor biology.
Is there a related FOA using a different mechanism (such as R21)?
Yes. This R01 announcement is explicitly paired with a parallel announcement of the same scientific scope that uses the R21 mechanism: PAS-06-466. The R21 mechanism is often used for earlier-stage, higher-risk exploratory or developmental ideas.
Is funding guaranteed under PAS-07-267?
No. Funding is not guaranteed. Awards depend on NIH appropriations and the availability of funds, as well as the volume and quality of applications received.
Does the FOA specify a fixed number of awards?
No. The announcement does not specify a fixed number of awards. It indicates that awards are contingent upon the submission of a sufficient number of meritorious proposals.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement under this funding opportunity.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. and non-U.S. organizations, including academic institutions, nonprofit organizations (with or without 501(c)(3) status as long as they otherwise qualify), governmental entities, tribal governments and tribally designated organizations, small businesses, for-profit organizations (including for-profits other than small businesses), foreign institutions, and eligible agencies of the federal government. Faith-based and community-based organizations are also explicitly listed as eligible.
Are U.S. colleges and universities eligible?
Yes. Eligible academic institutions include public/state controlled institutions of higher education and private institutions of higher education.
Are minority-serving institutions eligible?
Yes. The announcement lists multiple minority-serving institution categories as eligible, including Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Can nonprofit organizations apply if they do not have 501(c)(3) status?
Yes. The FOA states that nonprofit organizations are eligible whether or not they have 501(c)(3) status, as long as they otherwise qualify.
What types of government organizations are eligible?
The FOA includes a wide range of governmental entities, including state governments, county governments, city or township governments, U.S. territories or possessions, special district governments, and independent school districts.
Are tribal governments and tribal organizations eligible?
Yes. Applications are permitted from tribal governments (both federally recognized and other than federally recognized) and from tribally designated organizations.
Can small businesses and for-profit organizations apply?
Yes. The eligibility list includes small businesses and for-profit organizations, including for-profits other than small businesses.
Are foreign institutions eligible to apply?
Yes. Foreign institutions are explicitly listed as eligible applicants.
Can U.S. federal agencies apply?
Yes. The announcement indicates that eligible agencies of the federal government may apply.
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly listed as eligible.
How is this opportunity categorized within NIH and federal assistance?
Administratively, this opportunity is categorized as a discretionary grant under NIH.
Which CFDA areas are associated with this FOA?
The activity and program relevance spans multiple CFDA areas, including Environmental Health (93.113), Cancer Biology Research (93.396), Diabetes, Digestive, and Kidney Diseases Extramural Research (93.847), and Aging Research (93.866). This reflects the cross-cutting nature of nuclear receptor research across multiple biological systems and disease areas.
When was PAS-07-267 posted?
The opportunity was posted on December 22, 2006.
Did this FOA have a single application deadline?
No. It used multiple receipt dates rather than a single deadline, meaning submissions were accepted on recurring standard NIH due dates during the active period of the announcement.
Is PAS-07-267 still active?
No. The listing notes an archive date of June 1, 2009, indicating the FOA is no longer active in its original form.
Why might this archived FOA still be useful?
Even though it is archived, it can still serve as a reference point for the types of mechanism-focused research NIH sought to stimulate at the time regarding nuclear receptor signaling and its role in tissue and organismal aging and age-associated disease processes.
Where was the full announcement hosted?
The full announcement was hosted through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PAS-07-267.html
What should someone do if they have trouble accessing the announcement?
The posting indicated that applicants or readers who had trouble accessing the announcement should contact the NIH Office of Extramural Research (OER) webmaster via the email addresses listed in the original announcement.
What is the overall research emphasis of PAS-07-267 in plain terms?
The overall emphasis is on rigorous, mechanism-focused studies that explain how nuclear receptor signaling and its regulatory partners contribute to aging at the tissue level and across the whole organism, and how those pathways connect aging biology to the onset and progression of diseases that are more common in midlife and older adulthood.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAS 07 267) also looked into and applied for these:
| Funding Opportunity |
|---|
| Global Research Initiative Program, Behavioral/Social Sciences (R01) Apply for PAR 07 328 Funding Number: PAR 07 328 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $50,000 |
| Innovations in Biomedical Computational Science and Technology (R01) Apply for PAR 07 344 Funding Number: PAR 07 344 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Psychopharmacology of Widely Available Psychoactive Natural Products (R01) Apply for PA 07 374 Funding Number: PA 07 374 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Psychopharmacology Of Widely Available Psychoactive Natural Products (R03) Apply for PA 07 375 Funding Number: PA 07 375 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Predictive Multiscale Models of the Physiome in Health and Disease (R01) Apply for PAR 08 023 Funding Number: PAR 08 023 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Nanoscience and Nanotechnology in Biology and Medicine (R01) Apply for PA 08 052 Funding Number: PA 08 052 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Nanoscience and Nanotechnology in Biology and Medicine (R21) Apply for PA 08 053 Funding Number: PA 08 053 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R21) Apply for PA 08 141 Funding Number: PA 08 141 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R01) Apply for PA 08 140 Funding Number: PA 08 140 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Exploratory Collaborations with National Centers for Biomedical Computing (R21) Apply for PAR 08 183 Funding Number: PAR 08 183 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Collaborations with National Centers for Biomedical Computing (R01) Apply for PAR 08 184 Funding Number: PAR 08 184 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Metals in Medicine (R01) Apply for PA 08 251 Funding Number: PA 08 251 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Mechanism for Time Sensitive Research Opportunities (R21) Apply for PAR 07 345 Funding Number: PAR 07 345 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Innovations in Biomedical Computational Science and Technology Initiative (SBIR R43/R44) Apply for PAR 07 160 Funding Number: PAR 07 160 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Innovations in Biomedical Computational Science and Technology Initiative (STTR R41/R42) Apply for PAR 07 161 Funding Number: PAR 07 161 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Global Research Initiative Program, Basic/Biomedical Sciences (R01) Apply for PAR 07 239 Funding Number: PAR 07 239 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Innovations in Biomedical Computational Science and Technology (R01) Apply for PAR 09 218 Funding Number: PAR 09 218 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Exploratory Innovations in Biomedical Computational Science and Technology (R21) Apply for PAR 09 219 Funding Number: PAR 09 219 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 09 012 Funding Number: RFA ES 09 012 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Environmental Influences during Windows of Susceptibility in Breast Cancer Risk (U01) Apply for RFA ES 09 009 Funding Number: RFA ES 09 009 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $300,000 |
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