Opportunity Information: Apply for PA 07 397
Apply for PA 07 397
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Understanding and Treating Generalized and Focal Dystonias (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.173 Research Related to Deafness and Communication Disorders 93.361 Nursing Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 12, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses County governments Others (see text field entitled Additional Information on Eligibility for clarification) State governments Special district governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments).
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
This funding opportunity, titled "Understanding and Treating Generalized and Focal Dystonias (R01)" (PA-07-397), is an NIH research grant program focused on advancing the scientific and clinical understanding of dystonia and accelerating progress toward better treatments. It is sponsored primarily by the National Institute of Neurological Disorders and Stroke (NINDS), with participation from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute on Deafness and Other Communication Disorders (NIDCD), and the National Institute of Environmental Health Sciences (NIEHS). It is also supported in collaboration with major dystonia-focused nonprofits, including the Dystonia Medical Research Foundation (DMRF) and the Bachmann Strauss Dystonia and Parkinson Foundation, Inc., reflecting an effort to align federal research priorities with patient and foundation-driven needs in the dystonia community.
The core purpose of the announcement is to invite R01 applications that address generalized and focal dystonias through basic, translational, and clinical research. The FOA emphasizes several broad goals: clarifying the pathophysiology of dystonia (in other words, identifying the biological and neurological mechanisms that cause or sustain dystonic symptoms), building and improving research resources that can speed discovery (such as tools, datasets, models, or other infrastructure that make dystonia studies easier and more powerful), and pushing promising therapeutic directions forward more quickly. Another explicit priority is promoting interdisciplinary collaboration, meaning the program is designed to encourage interaction across fields that do not always work closely together, such as neuroscience, genetics, pharmacology, bioengineering, rehabilitation, pediatrics, speech and hearing sciences, and environmental health. The overall intent is to strengthen the dystonia research pipeline from foundational mechanism studies to studies that can realistically inform new or improved interventions.
In terms of funding structure, the program uses the NIH R01 mechanism, which is the standard NIH grant format for mature, hypothesis-driven research projects that typically require a multi-year plan and a well-developed approach. This FOA is described as running in parallel with a separate but scientifically identical announcement that uses the R21 exploratory/developmental mechanism (PA-07-398). Practically, that means investigators can choose the pathway that matches the maturity of their idea: an R01 for more established research programs with substantial preliminary support, and an R21 for earlier-stage, higher-risk concepts that may be less developed but potentially transformative.
Award decisions are described as contingent on the availability of funds and the receipt of enough highly competitive applications, and the announcement does not guarantee a fixed number of awards. The opportunity is listed as having multiple receipt dates rather than a single deadline, so applicants would be expected to consult the full NIH announcement for the specific submission cycles and dates active during the FOA period. The announcement was originally posted on July 12, 2007, and later archived on August 5, 2010, which indicates it was active historically during that period and is not currently open unless reissued in a newer form.
Eligibility is broad and includes a wide range of applicant organizations. Eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) entities), small businesses and other for-profit organizations (excluding for-profits other than small businesses in some NIH contexts, though this listing explicitly includes for-profit organizations other than small businesses as eligible here), and multiple levels of government such as state, county, city or township governments, special district governments, and certain housing authorities. Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments) are also eligible. The FOA further notes that foreign institutions may apply, that eligible federal agencies may apply, and that faith-based or community-based organizations are not excluded, as long as they meet NIH grant requirements. There is no cost sharing or matching requirement, which is typical for NIH research grants and reduces barriers for academic and nonprofit applicants.
Administratively, the opportunity is categorized as a discretionary grant and is tied to several CFDA program areas reflecting the participating NIH institutes and related research domains, including neuroscience and neurological disorders, child health and development, deafness and communication disorders, and environmental health. The full technical details, requirements, and any institute-specific interests were provided through the NIH grants guide page linked in the announcement. For access issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster, which suggests the main point of contact in the provided text is for technical problems with the announcement rather than scientific program questions.
Frequently Asked Questions (FAQs)
What is the title and identifier of this funding opportunity?
The opportunity is titled "Understanding and Treating Generalized and Focal Dystonias (R01)" and the funding opportunity announcement (FOA) identifier is PA-07-397.
What is the main purpose of this FOA?
This FOA invites NIH R01 research grant applications aimed at advancing the scientific and clinical understanding of generalized and focal dystonias and accelerating progress toward better treatments.
Which NIH Institute is the primary sponsor?
The FOA is sponsored primarily by the National Institute of Neurological Disorders and Stroke (NINDS).
Which other NIH Institutes participate in this FOA?
Participating NIH Institutes include:
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- National Institute of Environmental Health Sciences (NIEHS)
Are any nonprofit organizations involved or mentioned?
Yes. The FOA is described as supported in collaboration with dystonia-focused nonprofits, including the Dystonia Medical Research Foundation (DMRF) and the Bachmann Strauss Dystonia and Parkinson Foundation, Inc.
What kinds of research does this FOA support?
The FOA supports basic, translational, and clinical research focused on generalized and focal dystonias.
What scientific goals or priorities are emphasized?
The FOA highlights several broad priorities, including:
- Clarifying dystonia pathophysiology (identifying biological and neurological mechanisms that cause or sustain dystonic symptoms)
- Developing/improving research resources (tools, datasets, models, or infrastructure to speed discovery)
- Accelerating therapeutic progress toward new or improved interventions
- Promoting interdisciplinary collaboration across fields relevant to dystonia research
What does "interdisciplinary collaboration" mean in the context of this FOA?
It means the FOA is intended to encourage collaboration across fields that may not always work closely together, such as neuroscience, genetics, pharmacology, bioengineering, rehabilitation, pediatrics, speech and hearing sciences, and environmental health.
What grant mechanism is used for this opportunity?
This FOA uses the NIH R01 mechanism, which is a standard NIH grant format typically used for mature, hypothesis-driven projects that require a multi-year plan and a well-developed research approach.
Is there a related FOA for exploratory or early-stage ideas?
Yes. This FOA is described as running in parallel with a separate but scientifically identical announcement using the R21 exploratory/developmental mechanism (PA-07-398).
How should an investigator decide between R01 and R21 for this topic area?
Based on the description provided: investigators would generally choose an R01 for more established research programs with substantial preliminary support, and an R21 for earlier-stage, higher-risk concepts that may be less developed but potentially transformative.
Does this FOA guarantee a certain number of awards?
No. Award decisions are described as contingent on the availability of funds and the receipt of a sufficient number of highly competitive applications, and the announcement does not guarantee a fixed number of awards.
Is there a single application deadline?
No. The opportunity is described as having multiple receipt dates rather than a single deadline. Applicants are expected to consult the full NIH announcement for the specific submission cycles and dates that were active during the FOA period.
When was this FOA posted, and is it still active?
The announcement was originally posted on July 12, 2007 and later archived on August 5, 2010. That indicates it was active historically during that period and is not currently open unless it has been reissued in a newer form.
What types of organizations are eligible to apply?
Eligibility is broad. The FOA lists multiple categories of eligible applicants, including:
- Public and private institutions of higher education
- Nonprofits (including 501(c)(3) and non-501(c)(3) organizations)
- Small businesses
- Other for-profit organizations (the listing explicitly includes for-profit organizations other than small businesses as eligible)
- State, county, city, township, and special district governments
- Certain housing authorities
- Native American tribal governments (federally recognized)
- Tribal organizations (other than federally recognized tribal governments)
- Foreign institutions
- Eligible federal agencies
Are faith-based or community-based organizations excluded?
No. The FOA notes that faith-based or community-based organizations are not excluded, as long as they meet NIH grant requirements.
Are foreign institutions allowed to apply?
Yes. The FOA explicitly notes that foreign institutions may apply.
Are federal agencies allowed to apply?
Yes. The FOA indicates that eligible federal agencies may apply.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What type of award is this categorized as?
The opportunity is categorized as a discretionary grant.
What program areas (CFDA) are associated with this FOA?
The FOA is tied to several CFDA program areas reflecting participating NIH institutes and research domains, including:
- Neuroscience and neurological disorders
- Child health and development
- Deafness and communication disorders
- Environmental health
Where are the full technical requirements and institute-specific interests described?
The text indicates that full technical details, requirements, and any institute-specific interests were provided through the NIH grants guide page linked in the announcement.
Who is listed as the contact for access or technical issues?
The contact listed for access issues is the NIH Office of Extramural Research (OER) webmaster, suggesting the provided contact is primarily for technical problems with the announcement rather than scientific program questions.
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