Opportunity Information: Apply for PA 07 398
Apply for PA 07 398
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Understanding and Treating Generalized and Focal Dystonias (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.173 Research Related to Deafness and Communication Disorders 93.361 Nursing Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 12, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Private institutions of higher education Public and State controlled institutions of higher education State governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments City or township governments Native American tribal governments (Federally recognized) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) County governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The grant opportunity titled "Understanding and Treating Generalized and Focal Dystonias (R21)" (Funding Opportunity Number PA-07-398) is an NIH discretionary research grant designed to push forward new ideas and early-stage projects focused on dystonia, including both generalized and focal forms. It is sponsored by several NIH institutes, led by the National Institute of Neurological Disorders and Stroke (NINDS) and joined by NICHD, NIDCD, and NIEHS, with additional partnership support from the Dystonia Medical Research Foundation (DMRF) and the Bachmann Strauss Dystonia and Parkinson Foundation. The overall intent is to broaden and accelerate dystonia research by supporting basic, translational, and clinical studies that clarify the underlying pathophysiology, develop tools and resources that the field needs, and move promising therapeutic concepts closer to practical use. A major emphasis is also placed on encouraging interdisciplinary collaboration, reflecting the idea that progress in dystonia often depends on integrating perspectives from neuroscience, genetics, physiology, pharmacology, engineering, rehabilitation, and clinical neurology.
This funding announcement uses the NIH Exploratory/Developmental Research Grant mechanism (R21), which is commonly aimed at supporting high-impact, innovative, or preliminary projects that may still be early in development but have strong potential to open new directions. The opportunity runs in parallel with a separate announcement of the same scientific scope that uses the traditional R01 mechanism (PA-07-397), meaning applicants with a more mature, fully developed research program might consider the R01 route, while applicants proposing proof-of-concept work, pilot clinical studies, early translational steps, or creation of enabling resources may fit well within the R21 structure. The listed award ceiling is $200,000, and there is no cost sharing or matching requirement.
In practical terms, the FOA is looking for research that improves understanding of how dystonia arises and persists in the nervous system and how it can be treated more effectively. That includes work that investigates disease mechanisms and neural circuit dysfunction, identifies biological or environmental contributors, develops or validates models and measures relevant to dystonia, and tests therapeutic strategies that could ultimately improve outcomes for patients. The language of the announcement makes clear that it is not limited to one research lane; it explicitly welcomes basic science that explains mechanisms, translational work that builds bridges to interventions, and clinical research that evaluates therapeutic approaches or improves clinical understanding and management. It also signals interest in resource-building projects, meaning efforts like developing assays, datasets, biomarkers, standardized measures, shared tools, or other research infrastructure that can make dystonia studies faster, more comparable across groups, and more reproducible.
Funding decisions under this FOA depend on the availability of funds and the strength of the application pool. NIH does not commit to a fixed number of awards here; instead, the number and size of awards can vary depending on scientific merit, project duration, and proposed costs. The opportunity is categorized as a grant, and the activity areas listed span multiple CFDA numbers reflecting the participating institutes and the cross-cutting relevance of dystonia research, including neuroscience and neurological disorders, child health and development, deafness and communication disorders, and environmental health.
Eligibility is broad and includes a wide range of organizations: public and private institutions of higher education, state and local governments (including counties, cities, townships, and special districts), tribal governments and tribal organizations, independent school districts, public/Indian housing authorities, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), and for-profit organizations (other than small businesses are explicitly listed, though small businesses are also included). The announcement also states that foreign institutions are eligible, eligible federal agencies may apply, and faith-based or community-based organizations are allowed to submit applications. The FOA was posted July 12, 2007, has multiple receipt dates (rather than a single deadline), and was archived on August 16, 2010, indicating it is a historical funding announcement rather than an active, current opportunity. The full announcement was hosted on the NIH grants website at the provided link, and NIH Office of Extramural Research (OER) webmaster contacts are included for access or linking issues.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Understanding and Treating Generalized and Focal Dystonias (R21)" and the Funding Opportunity Number is PA-07-398.
What type of grant mechanism is used for this opportunity?
This announcement uses the NIH Exploratory/Developmental Research Grant mechanism (R21), which is designed to support innovative, early-stage, or high-impact exploratory projects that can open up new research directions.
What is the overall purpose of this funding opportunity?
The intent is to broaden and accelerate dystonia research by supporting basic, translational, and clinical studies that (1) clarify underlying pathophysiology, (2) develop tools and resources the field needs, and (3) move promising therapeutic concepts closer to practical use.
Which forms of dystonia are included?
The scope includes both generalized dystonia and focal dystonia.
Which NIH institutes and partners are involved?
The FOA is led by the National Institute of Neurological Disorders and Stroke (NINDS) and joined by NICHD, NIDCD, and NIEHS. It also includes additional partnership support from the Dystonia Medical Research Foundation (DMRF) and the Bachmann Strauss Dystonia and Parkinson Foundation.
What kinds of research are encouraged under this FOA?
The announcement welcomes a wide range of dystonia-focused work, including basic, translational, and clinical studies. Examples described in the FOA include investigating disease mechanisms and neural circuit dysfunction, identifying biological or environmental contributors, developing or validating models and measures relevant to dystonia, and testing therapeutic strategies that could improve patient outcomes.
Does the FOA encourage interdisciplinary or collaborative research?
Yes. A major emphasis is placed on encouraging interdisciplinary collaboration, reflecting the view that progress in dystonia often depends on integrating perspectives across areas such as neuroscience, genetics, physiology, pharmacology, engineering, rehabilitation, and clinical neurology.
Are clinical studies allowed under this opportunity?
Yes. The FOA explicitly welcomes clinical research that evaluates therapeutic approaches or improves clinical understanding and management of dystonia.
Are basic science and translational projects allowed?
Yes. The FOA explicitly welcomes basic studies aimed at mechanisms and pathophysiology, as well as translational work intended to bridge discoveries toward interventions.
Does the FOA support development of tools, datasets, or other resources?
Yes. The announcement signals interest in resource-building projects, including efforts such as developing assays, datasets, biomarkers, standardized measures, shared tools, or other research infrastructure that can make dystonia studies faster, more comparable across groups, and more reproducible.
What is the award ceiling for this R21 opportunity?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Is the number of awards fixed?
No. NIH does not commit to a fixed number of awards for this FOA. The number and size of awards can vary depending on the availability of funds and the strength of the application pool, as well as scientific merit, project duration, and proposed costs.
How are funding decisions made?
Funding decisions depend on the availability of funds and the strength of the application pool. The FOA also indicates awards can vary based on scientific merit, project duration, and proposed costs.
Is there a related R01 opportunity with the same scientific scope?
Yes. This R21 FOA runs in parallel with a separate announcement of the same scientific scope that uses the traditional R01 mechanism (PA-07-397). The R01 route may be more appropriate for a more mature, fully developed research program, while the R21 may fit proof-of-concept work, early translational steps, pilot clinical studies, or enabling resource creation.
What types of applicants or organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; state and local governments (including counties, cities, townships, and special districts); tribal governments and tribal organizations; independent school districts; public/Indian housing authorities; nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities); and for-profit organizations (with small businesses also included). The FOA also states that foreign institutions are eligible, eligible federal agencies may apply, and faith-based or community-based organizations are allowed to submit applications.
Are foreign institutions eligible?
Yes. The announcement states that foreign institutions are eligible to apply.
Can for-profit organizations apply?
Yes. For-profit organizations are listed as eligible applicants, and small businesses are also included.
Can nonprofits apply even if they are not 501(c)(3) organizations?
Yes. The eligibility list includes nonprofit organizations with and without 501(c)(3) status.
Can faith-based or community-based organizations apply?
Yes. The FOA states that faith-based or community-based organizations are allowed to submit applications.
Can government entities apply?
Yes. Eligible applicants include state and local governments, tribal governments, and eligible federal agencies.
Is this an active funding opportunity?
No. The FOA was archived on August 16, 2010, indicating it is a historical funding announcement rather than an active, current opportunity.
When was this FOA posted and when was it archived?
It was posted on July 12, 2007, and archived on August 16, 2010.
Does this opportunity have a single deadline?
No. The FOA indicates multiple receipt dates rather than a single deadline.
What research and program areas does this opportunity span?
The activity areas span multiple CFDA numbers reflecting participation across NIH institutes and the cross-cutting relevance of dystonia research, including neuroscience and neurological disorders, child health and development, deafness and communication disorders, and environmental health.
Where was the full announcement hosted, and who is listed for technical website issues?
The full announcement was hosted on the NIH grants website at the provided link. NIH Office of Extramural Research (OER) webmaster contacts are included for access or linking issues.
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