Opportunity Information: Apply for RFA HL 15 023
Apply for RFA HL 15 023
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Vascular Dysfunction in the Pathogenesis of Severe Malaria (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Jan 27, 2015 and posted on Oct 9, 2014.
- Applicants must submit their applications by Feb 19, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,700,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Native American tribal governments (Federally recognized) County governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments City or township governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "Vascular Dysfunction in the Pathogenesis of Severe Malaria (R01)" (Funding Opportunity Number RFA HL 15 023) is a discretionary National Institutes of Health (NIH) research grant that focuses on how blood vessel activation, injury, and malfunction contribute to severe malaria. The central aim is to support collaborative, multi-Principal Investigator research teams that can tackle the vascular side of malaria pathogenesis, with an emphasis on uncovering the biological pathways and regulatory mechanisms that connect malaria infection to vascular activation and downstream clinical complications. The overall intent is to move beyond viewing severe malaria only as a parasite-driven disease and instead clarify how host vascular responses help shape disease severity, complications, and outcomes.
A key feature of this funding announcement is its strong emphasis on multidisciplinary and collaborative science. NIH is explicitly looking for applications that bring together investigators from different areas of expertise, since severe malaria is complex and is likely driven by multiple interacting processes involving the parasite, immune responses, endothelial cells, coagulation pathways, inflammatory mediators, and organ-specific vascular effects. Projects are expected to address how vascular factors contribute to the broader etiology of severe malaria, meaning applicants should propose integrated studies that can explain mechanisms rather than isolated observations. The announcement is structured around the idea that understanding vascular activation and dysfunction could reveal actionable targets for prevention, risk stratification, or adjunctive therapies that reduce mortality and severe complications.
This opportunity uses the NIH R01 funding mechanism, which supports hypothesis-driven, multi-year research projects. NIH anticipated making about six awards under this announcement, with an estimated total funding amount of approximately $2.7 million. The award ceiling is listed as $300,000, indicating the maximum award amount NIH expects for individual projects under this specific solicitation. There is no cost-sharing or matching requirement, which means applicants are not required to provide institutional or external funds as a condition of receiving the award.
The eligible applicant pool is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both 501(c)(3) and certain non-501(c)(3) organizations other than institutions of higher education), for-profit organizations (other than small businesses), and small businesses. A wide range of government entities are also eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The announcement also recognizes a variety of mission-driven and community-rooted institutions as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based and community-based organizations are included among eligible agencies as well.
At the same time, the eligibility rules draw clear boundaries around non-U.S. applicants. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, the announcement allows "foreign components" as defined in NIH policy, meaning a U.S. applicant may include certain foreign collaborations or activities if they meet NIH requirements and are justified scientifically. This is an important nuance for malaria research, since the highest burden of severe malaria occurs outside the United States, and meaningful clinical and translational studies often depend on international partnerships, sample access, or field-based data collection.
Administratively, the funding opportunity falls under the NIH funding activity category of Health and is associated with CFDA number 93.839, Blood Diseases and Resources Research. The opportunity was posted on October 9, 2014, with a creation date of January 27, 2015. The original closing date was February 13, 2015, and the current closing date was February 19, 2015, with an archive date of March 19, 2015. The sponsoring agency is the National Institutes of Health, and the full announcement was made available through the NIH grants guide at the provided link. For technical issues accessing or linking to the announcement, the listed support contact is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV).
In practical terms, applicants responding to this FOA would be expected to propose a research plan that directly addresses how vascular activation and dysfunction contribute to severe malaria outcomes, and to do so with a collaborative structure that reflects the complexity of the problem. Strong applications would likely connect vascular biology to clinically relevant endpoints in severe malaria and describe how the team will identify mechanisms, regulatory pathways, and potential intervention points, all within the scope and budget constraints of an R01 award under this solicitation.
FAQs: Vascular Dysfunction in the Pathogenesis of Severe Malaria (R01) (RFA HL 15 023)
What is the title of this grant opportunity?
The opportunity is titled "Vascular Dysfunction in the Pathogenesis of Severe Malaria (R01)" and is identified by Funding Opportunity Number (FON) RFA HL 15 023.
Which agency is sponsoring this funding opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism is being used?
This opportunity uses the NIH R01 mechanism, which supports hypothesis-driven, multi-year research projects.
What is the main scientific focus of this FOA?
The FOA focuses on how blood vessel activation, injury, and malfunction (vascular activation and dysfunction) contribute to the development (pathogenesis) of severe malaria and its downstream clinical complications.
What is the central aim of the research NIH wants to support?
The central aim is to support collaborative, multi-Principal Investigator research teams that can uncover biological pathways and regulatory mechanisms linking malaria infection to vascular activation and the clinical complications that follow.
What problem is NIH trying to address through this funding announcement?
The intent is to move beyond viewing severe malaria only as a parasite-driven disease and to clarify how host vascular responses shape disease severity, complications, and outcomes.
Does this FOA prioritize collaborative and multidisciplinary projects?
Yes. A key feature is a strong emphasis on multidisciplinary and collaborative science, with NIH explicitly seeking teams that bring together different areas of expertise to address the complexity of severe malaria.
Why is a multidisciplinary approach emphasized for severe malaria research?
Because severe malaria likely involves multiple interacting processes, including the parasite, immune responses, endothelial cells, coagulation pathways, inflammatory mediators, and organ-specific vascular effects.
What kinds of research approaches appear to fit this FOA based on the description?
Projects are expected to propose integrated studies that explain mechanisms (pathways and regulatory mechanisms) connecting malaria infection to vascular activation and clinically meaningful outcomes, rather than isolated observations.
What outcomes or long-term impacts is NIH hoping this research will enable?
The FOA indicates that understanding vascular activation and dysfunction could reveal actionable targets for prevention, risk stratification, or adjunctive therapies aimed at reducing mortality and severe complications.
How many awards does NIH expect to make?
NIH anticipated making about six awards under this announcement.
What is the estimated total funding amount for this FOA?
The estimated total funding amount is approximately $2.7 million.
Is there a maximum award amount for individual projects?
Yes. The award ceiling is listed as $300,000, indicating the maximum award amount NIH expects for individual projects under this solicitation.
Is cost sharing or matching required?
No. There is no cost-sharing or matching requirement.
Who is eligible to apply as the applicant organization?
The eligible applicant pool is broad and includes U.S.-based organizations and governmental entities such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations other than institutions of higher education), for-profit organizations (other than small businesses), and small businesses.
Are government entities eligible to apply?
Yes. Eligible government applicants include state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are minority-serving institutions specifically included as eligible applicants?
Yes. The FOA includes eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are included among eligible agencies.
Can a foreign organization apply as the primary applicant?
No. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply as the applicant organization.
Are non-U.S. components of U.S. organizations eligible to apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply as the applicant organization.
Are any international activities or partnerships allowed under this FOA?
Yes. While foreign organizations cannot be the applicant, the FOA allows "foreign components" as defined in NIH policy, meaning a U.S. applicant may include certain foreign collaborations or activities if they meet NIH requirements and are scientifically justified.
Why does the FOA mention foreign components as a relevant nuance?
Because the highest burden of severe malaria occurs outside the United States, and meaningful clinical and translational studies often depend on international partnerships, access to samples, or field-based data collection.
What is the funding activity category for this opportunity?
The funding activity category is Health.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.839, Blood Diseases and Resources Research.
When was the opportunity posted and created?
The opportunity was posted on October 9, 2014, with a creation date of January 27, 2015.
What were the closing dates and archive date?
The original closing date was February 13, 2015. The current closing date was February 19, 2015. The archive date was March 19, 2015.
Where was the full announcement made available?
The full announcement was made available through the NIH grants guide at the provided link in the opportunity description.
Who should be contacted for technical issues with accessing or linking to the announcement?
For technical issues accessing or linking to the announcement, the listed support contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What kind of team structure does NIH appear to be encouraging?
The FOA emphasizes collaborative, multi-Principal Investigator research teams and expects a structure that reflects the complexity of severe malaria and vascular dysfunction.
What would a responsive application likely include, based on the description provided?
A responsive application would propose a research plan that directly addresses how vascular activation and dysfunction contribute to severe malaria outcomes, links vascular biology to clinically relevant endpoints, and identifies mechanisms, regulatory pathways, and potential intervention points within the scope and budget constraints of an R01 under this solicitation.
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