Opportunity Information: Apply for RFA IP 11 001
Apply for RFA IP 11 001
- The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Virologic Evaluation of the Modes of Influenza Virus Transmission among Humans (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.283 Centers for Disease Control and PreventionInvestigations and Technical Assistance.
- This funding opportunity was created on Feb 23, 2011 and posted on Feb 16, 2011.
- Applicants must submit their applications by Apr 5, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $12,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Eligible Organizations Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for CDC support as Public or Private Institutions of Higher Education Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Nonprofits Other Than Institutions of Higher Education Nonprofits (Other than Institutions of Higher Education) Governments State Governments County Governments City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Other Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American tribal organizations (other than Federally recognized tribal governments) Faith based or Community based Organizations Regional Organizations Bona Fide Agents Non domestic (non U.S.) Entities (Foreign Organizations) A Bona Fide Agent is an agency/organization identified by the state as eligible to submit an application under the state eligibility in lieu of a state application. If applying as a bona fide agent of a state or local government, a legal, binding agreement from the state or local government as documentation of the status is required. Attach with Other Attachment Forms when submitting via www.grants.gov. Non domestic (non U.S.) Entities (Foreign Organizations) are eligible to apply.
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Opportunity Summary:
The Centers for Disease Control and Prevention (CDC) released this funding opportunity, RFA IP 11 001, titled "Virologic Evaluation of the Modes of Influenza Virus Transmission among Humans (U01)," to support carefully designed human influenza transmission studies that can pin down how influenza spreads from person to person. The main scientific aim is practical and public health oriented: determine the relative contribution of different transmission pathways (for example, spread through close contact, respiratory droplets, airborne particles, or contaminated environments), clarify how long infected people shed virus, and understand how influenza contaminates surfaces and surrounding air and how that contamination relates to onward transmission. The FOA is focused on virologic evaluation in real human transmission contexts, not theoretical modeling alone, and not studies that simply look at immunology or vaccine response without directly addressing transmission.
A key boundary in the announcement is what CDC does not want applicants to propose. Any study that involves deliberately exposing humans to vaccine strains, whether from live attenuated influenza vaccine (LAIV) or from inactivated vaccines, is explicitly considered unresponsive. In other words, proposals need to center on transmission studies relevant to circulating or clinically relevant influenza virus in humans, rather than using vaccine strains as the exposure agent. This is an important screening criterion, because an otherwise strong application could be rejected for responsiveness if it relies on vaccine-strain challenge or exposure as the core design.
The award mechanism is a cooperative agreement (U01), which generally means CDC expects substantial scientific or programmatic involvement during the project rather than a hands-off grant. Applicants should typically anticipate collaboration with CDC on study coordination, methods, data sharing expectations, and possibly harmonization across sites or projects, depending on how the program is structured. The opportunity sits in the health activity category and is associated with CFDA 93.283, CDC Investigations and Technical Assistance, indicating a strong applied research and public health implementation flavor.
Funding for the program was sizable for a focused set of studies: an estimated total of $12,000,000 with an expectation of about three awards. The notice lists an award ceiling and floor of $0, which usually signals that applicants must rely on the detailed announcement for budget guidance and that CDC is not setting a strict per-award cap in the summary fields. There is no cost sharing or matching requirement, so applicants are not required to provide non-federal matching funds as a condition of eligibility.
Eligibility is broad and intentionally inclusive. Higher education institutions (both public/state controlled and private) are eligible, and CDC explicitly encourages applications from institutions that serve historically underrepresented communities, including Hispanic-serving institutions, HBCUs, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions. Beyond universities, eligible applicants include nonprofits (other than institutions of higher education), a wide range of government entities (state, county, city/township, special district, tribal governments both federally recognized and other than federally recognized, and U.S. territories/possessions), and additional organization types such as independent school districts, public housing authorities/Indian housing authorities, faith-based and community-based organizations, regional organizations, and bona fide agents. Foreign organizations (non-U.S. entities) are also eligible to apply, which is notable for influenza transmission research given the global nature of influenza circulation and the value of diverse settings for transmission studies.
The timeline indicates this was a 2011 opportunity with a posted date of February 16, 2011, and an original closing date of March 29, 2011, later extended to April 5, 2011, with an archive date of April 28, 2011. While the dates are historical, the scope communicates CDC priorities at the time: obtaining rigorous empirical evidence on transmission modes, shedding duration, and environmental contamination to inform infection control guidance, community mitigation strategies, and preparedness planning.
For applicant support, CDC listed its Procurement and Grants Office contact point for access issues with the full announcement: the TIMS line at 770-488-2700 and PGOTIM@cdc.gov. This contact is administrative rather than scientific, suggesting that detailed technical questions would typically be addressed through the full FOA text and any listed scientific/program contacts within it.
FAQs: RFA IP 11 001 - Virologic Evaluation of the Modes of Influenza Virus Transmission among Humans (U01)
What is this CDC funding opportunity?
This CDC funding opportunity is RFA IP 11 001, titled "Virologic Evaluation of the Modes of Influenza Virus Transmission among Humans (U01)." It is intended to support carefully designed studies in humans that help clarify how influenza spreads from person to person using virologic evidence from real transmission contexts.
What is the primary goal of the studies supported by this FOA?
The main goal is practical and public health oriented: to determine the relative contribution of different influenza transmission pathways and generate evidence that can inform infection control guidance, community mitigation strategies, and preparedness planning.
Which influenza transmission pathways does CDC want applicants to evaluate?
The FOA highlights multiple possible pathways, including close contact, respiratory droplets, airborne particles, and contaminated environments (for example, surfaces and surrounding air).
What kinds of measurements or outcomes are emphasized?
The announcement emphasizes virologic evaluation that can: (1) clarify how long infected people shed virus, (2) understand how influenza contaminates surfaces and surrounding air, and (3) link that contamination to onward transmission among humans.
Is this FOA focused on modeling studies?
No. The FOA is focused on virologic evaluation in real human transmission contexts, not theoretical modeling alone.
Are immunology-only or vaccine-response studies a fit for this FOA?
Not by themselves. The FOA is not for studies that simply examine immunology or vaccine response without directly addressing influenza transmission.
What types of proposed studies are explicitly considered unresponsive?
Any study that involves deliberately exposing humans to vaccine strains is explicitly considered unresponsive. This includes exposure to strains from live attenuated influenza vaccine (LAIV) or from inactivated vaccines.
Does CDC allow using vaccine strains as the exposure agent if the rest of the study is strong?
No. The announcement states that deliberately exposing humans to vaccine strains is unresponsive, meaning an otherwise strong application could be rejected on responsiveness if vaccine-strain exposure is central to the design.
What award mechanism is used for this opportunity?
The award mechanism is a cooperative agreement (U01).
What does a U01 cooperative agreement imply for CDC involvement?
A U01 generally means CDC expects substantial scientific or programmatic involvement during the project rather than a hands-off approach. Applicants should anticipate collaboration with CDC on items such as study coordination, methods, data sharing expectations, and potentially harmonization across sites or projects (depending on how the program is structured).
What is the CFDA number and program association for this opportunity?
The opportunity is associated with CFDA 93.283, "CDC Investigations and Technical Assistance," and is categorized under the health activity area.
How much total funding did CDC estimate for this program?
The estimated total funding amount listed is $12,000,000.
How many awards did CDC expect to make?
The announcement indicates an expectation of about three awards.
Is there a per-award funding cap listed in the summary?
The notice lists an award ceiling and floor of $0. This typically indicates that applicants need to rely on the detailed announcement for budget guidance and that a strict per-award cap is not set in the summary fields.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of eligibility.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include institutions of higher education (public/state controlled and private), nonprofits (other than institutions of higher education), and many government entities (state, county, city/township, special district, tribal governments, and U.S. territories/possessions). Additional eligible organization types listed include independent school districts, public housing authorities/Indian housing authorities, faith-based and community-based organizations, regional organizations, and bona fide agents. Foreign organizations (non-U.S. entities) are also eligible.
Does CDC encourage applications from institutions serving historically underrepresented communities?
Yes. CDC explicitly encourages applications from institutions that serve historically underrepresented communities, including Hispanic-serving institutions, HBCUs, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions.
Are foreign organizations eligible to apply?
Yes. The announcement states that foreign organizations (non-U.S. entities) are eligible, which is notable given the global nature of influenza and the value of studying transmission in diverse settings.
When was this opportunity posted and when did it close?
The opportunity was posted on February 16, 2011. The original closing date was March 29, 2011, later extended to April 5, 2011. The archive date is April 28, 2011.
Is this funding opportunity still active?
The dates provided indicate it was a 2011 opportunity and it has an archive date of April 28, 2011, suggesting it is historical rather than currently open.
What is the main scientific theme of the FOA beyond transmission routes?
Beyond identifying transmission routes, the FOA emphasizes understanding the duration of viral shedding in infected people and how virus contamination in the environment (surfaces and surrounding air) relates to onward transmission.
Who is the listed contact for access issues with the full announcement?
CDC listed the Procurement and Grants Office contact point for access issues with the full announcement: the TIMS line at 770-488-2700 and PGOTIM@cdc.gov.
Is the listed contact intended for scientific questions about study design?
The information provided describes the contact as administrative (for access issues with the full announcement) rather than scientific, implying that technical questions would typically be addressed through the full FOA text and any scientific/program contacts listed there.
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