Opportunity Information: Apply for PAR 10 192
Apply for PAR 10 192
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Vulvodynia Systematic Epidemiologic, Etiologic or Therapeutic Studies (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on May 7, 2010 and posted on May 7, 2010.
- Applicants must submit their applications by Sep 21, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education City or township governments State governments Public and State controlled institutions of higher education Small businesses For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) County governments Others (see text field entitled Additional Information on Eligibility for clarification).
- Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Vulvodynia Systematic Epidemiologic, Etiologic or Therapeutic Studies (R21) opportunity (Funding Opportunity Number PAR-10-192) is a National Institutes of Health (NIH) grant solicitation designed to spur new, investigator-initiated research focused on vulvodynia and closely related symptom-based conditions. Vulvodynia is framed in the announcement as a chronic pelvic pain condition in women, and the overarching intent is to accelerate progress toward better diagnosis, prevention, and treatment. The FOA is intentionally broad in scientific scope, welcoming basic, clinical, translational, epidemiological, and behavioral studies, as long as they meaningfully advance understanding of the condition and support the longer-term goal of developing improved prevention and therapeutic strategies.
A central theme of the announcement is building the evidence base around what causes vulvodynia, how it develops over time, who is at risk, and which biological and behavioral mechanisms might be driving symptoms. NIH highlights several priority knowledge gaps that proposed projects are expected to address in some way, including the pathophysiology of vulvodynia, biologic risk factors, behavioral risk factors, the natural history of the condition, and potential genetic contributions. The FOA also signals interest in research that can clarify etiologic pathways and inform clinical decision-making, even when the work is early-stage, exploratory, or focused on developing new methods rather than delivering a fully validated intervention.
The award mechanism is the NIH Exploratory/Developmental Research Grant (R21), which is commonly used for early, high-impact ideas that may be at a proof-of-concept stage. In practical terms, that means this funding route is meant to encourage novel concepts, the creation or testing of new model systems, development of research tools, identification of promising targets, and exploration of innovative technologies or agents that could substantially move the field forward. The announcement explicitly positions the R21 as a way to bring fresh approaches into vulvodynia research, especially where preliminary data may be limited but the rationale and potential impact are strong.
This R21 FOA runs in parallel with two companion announcements that share the same scientific scope but use different NIH grant mechanisms: PAR-10-190 for the traditional R01 research project grant mechanism and PAR-10-191 for the R03 small research grant mechanism. Together, these linked options create multiple entry points for investigators depending on the maturity, scale, and resource needs of the proposed work, from smaller pilot projects (R03) to larger and more definitive studies (R01), with the R21 sitting in the middle as a development-oriented pathway aimed at innovation.
In terms of funding levels and the number of awards, the FOA does not set a single fixed budget or award count. Instead, NIH notes that the size and duration of awards will vary because proposed projects can differ substantially in scope and cost. The total dollars awarded and how many projects are funded are expected to depend on typical NIH factors such as the number of applications received under the mechanisms, their scientific quality, project duration, and requested costs. Cost sharing or matching is not required.
Eligibility is expansive and includes a wide range of domestic and non-domestic organizations. Eligible applicants listed include nonprofits (both 501(c)(3) and certain nonprofits without 501(c)(3) status), private and public institutions of higher education, public and state-controlled universities, for-profit organizations (including small businesses and other for-profits), and multiple levels of government (city/township, county, state, special district). The eligibility language also highlights inclusion of federally recognized tribal governments and other tribal organizations, U.S. territories or possessions, regional organizations, and foreign entities (non-U.S. organizations). It explicitly mentions a variety of institution types that NIH often aims to include and support, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, along with eligible federal agencies.
Administratively, the opportunity sits within the NIH program structure and is associated with CFDA 93.865 (Child Health and Human Development Extramural Research), indicating alignment with NIH interests in reproductive health and conditions affecting women’s health. The FOA was posted May 7, 2010, with an original and current closing date of September 21, 2012, and it was archived October 21, 2012, meaning it is no longer active for new submissions under those dates, though it remains useful as a reference for the type of research NIH sought to stimulate at the time. For full details, NIH provided the formal announcement link (http://grants.nih.gov/grants/guide/pa-files/PAR-10-192.html) and general support contacts (GrantsInfo and the NIH Office of Extramural Research webmaster) for access or technical issues with the posting.
Frequently Asked Questions (FAQs)
What is the funding opportunity name and number?
The opportunity is titled "Vulvodynia Systematic Epidemiologic, Etiologic or Therapeutic Studies (R21)" and the Funding Opportunity Number (FOA) is PAR-10-192.
Which agency is offering this grant opportunity?
This is a National Institutes of Health (NIH) grant solicitation.
What is the main goal of PAR-10-192?
The goal is to spur new, investigator-initiated research focused on vulvodynia and closely related symptom-based conditions, with the longer-term intent of accelerating progress toward better diagnosis, prevention, and treatment.
How is vulvodynia described in the announcement?
In this announcement, vulvodynia is framed as a chronic pelvic pain condition in women.
What kinds of research does the FOA encourage?
The FOA is broad and welcomes basic, clinical, translational, epidemiological, and behavioral studies, as long as the proposed work meaningfully advances understanding of vulvodynia and supports progress toward improved prevention and therapeutic strategies.
What scientific themes or questions does NIH want applicants to address?
NIH emphasizes building the evidence base for what causes vulvodynia, how it develops over time, who is at risk, and what biological and behavioral mechanisms may drive symptoms.
What specific knowledge gaps are highlighted as priorities?
The announcement highlights several priority gaps, including the pathophysiology of vulvodynia, biologic risk factors, behavioral risk factors, the natural history of the condition, and potential genetic contributions.
Does the FOA support early-stage or exploratory work?
Yes. NIH signals interest in early-stage and exploratory research, including efforts that develop new methods or clarify etiologic pathways, even if the work is not yet delivering a fully validated intervention.
What grant mechanism is used for this opportunity?
PAR-10-192 uses the NIH Exploratory/Developmental Research Grant mechanism (R21).
What is the R21 mechanism intended to support in this FOA?
The R21 is positioned as a way to support early, high-impact ideas that may be at a proof-of-concept stage, including novel concepts, new model systems, development of research tools, identification of promising targets, and exploration of innovative technologies or agents that could move the field forward.
Are preliminary data required to apply?
The FOA notes that the R21 is meant to encourage fresh approaches, particularly where preliminary data may be limited but the rationale and potential impact are strong.
Are there related or companion NIH announcements with the same scientific scope?
Yes. This FOA runs in parallel with two companion announcements covering the same scientific scope: PAR-10-190 (R01) and PAR-10-191 (R03).
How do the companion mechanisms (R01 and R03) relate to the R21?
Together, the R03, R21, and R01 create multiple entry points depending on the maturity and scale of the work: smaller pilot projects (R03), development-oriented innovation (R21), and larger/more definitive studies (R01).
Is there a fixed budget cap or set number of awards for this FOA?
No. The FOA does not set a single fixed budget or award count. NIH indicates that award size and duration may vary and that total dollars and the number of awards depend on factors such as the number of applications received, scientific quality, project duration, and requested costs.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
Who is eligible to apply?
Eligibility is expansive and includes many domestic and non-domestic organizations, including nonprofits (501(c)(3) and certain nonprofits without 501(c)(3) status), private and public institutions of higher education, public and state-controlled universities, for-profit organizations (including small businesses), and multiple levels of government (city/township, county, state, special district).
Are tribal organizations eligible?
Yes. The eligibility language includes federally recognized tribal governments and other tribal organizations.
Are U.S. territories and regional organizations eligible?
Yes. The eligibility language includes U.S. territories or possessions and regional organizations.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA explicitly includes foreign entities (non-U.S. organizations) as eligible applicants.
Does NIH explicitly encourage applications from specific institution types?
Yes. The eligibility language explicitly mentions institution types NIH often aims to include and support, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, along with eligible federal agencies.
What CFDA number is associated with this opportunity?
The FOA is associated with CFDA 93.865 (Child Health and Human Development Extramural Research).
When was the FOA posted, and what were the closing dates?
The FOA was posted on May 7, 2010. The original and current closing date listed is September 21, 2012.
Is this opportunity still open for new submissions?
No. The FOA was archived on October 21, 2012, meaning it is no longer active for new submissions under those dates.
Where can applicants find the official NIH announcement?
The official announcement link provided is: http://grants.nih.gov/grants/guide/pa-files/PAR-10-192.html
Who is listed for general support or technical issues related to the posting?
NIH provided general support contacts including GrantsInfo and the NIH Office of Extramural Research webmaster for access or technical issues with the posting.
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