Opportunity Information: Apply for PA 07 081
Apply for PA 07 081
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Women s Mental Health in Pregnancy and the Postpartum Period (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Nov 22, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Private institutions of higher education Public housing authorities/Indian housing authorities State governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments City or township governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Small businesses.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Women s Mental Health in Pregnancy and the Postpartum Period (R01) opportunity (Funding Opportunity Number PA 07 081) is a National Institutes of Health discretionary grant announcement that supports research projects focused on mental health during pregnancy and after childbirth. The overall aim is to strengthen the evidence base around perinatal mental disorders by funding studies that improve understanding of how these conditions begin, how they progress, what biological and social factors shape risk, and which treatments and care approaches work best in real-world settings. The scope is broad, covering both mood and other mental disorders occurring during the perinatal window, and it explicitly includes attention to both non psychotic conditions (such as perinatal depression and anxiety spectrum problems) and psychotic disorders (including severe postpartum presentations). A notable emphasis is placed on research that considers substance use history and substance use disorders, including how current or lifetime drug abuse, treatment status, and common comorbid conditions may influence the onset, severity, and course of perinatal mental health problems.
The FOA highlights four main research lanes that applicants are encouraged to pursue. First is clinical course, epidemiology, and risk factors, which can include work on incidence and prevalence, trajectories across pregnancy and postpartum, identification of high-risk groups, and disentangling contributors such as prior psychiatric history, stress exposure, social determinants, obstetric complications, and family context. Second is basic and clinical neuroscience, supporting studies that examine biological mechanisms and neurobehavioral processes related to perinatal mental illness, potentially spanning hormonal shifts, stress systems, neural circuitry, genetics, or other biomarkers, as well as clinically oriented translational work. Third is interventions, which can involve developing, testing, or optimizing preventive and therapeutic strategies, including pharmacologic and non pharmacologic approaches, and examining safety, effectiveness, and implementation issues specific to pregnancy and lactation contexts. Fourth is services research, which is oriented toward how care is delivered, accessed, coordinated, and paid for, including models that integrate screening, referral, and treatment into prenatal, obstetric, pediatric, and community settings, along with efforts to improve quality and outcomes.
In terms of funding structure, this announcement uses the NIH Research Project Grant (R01) mechanism, which is typically intended for larger, hypothesis-driven projects that can support substantial multi-year research programs. The FOA notes that it runs in parallel with a separate announcement of the same scientific scope that uses the R21 exploratory developmental mechanism (PA 06 377), signaling that NIH was also seeking earlier-stage or higher-risk pilot style work through that companion route while reserving this R01 for more developed research plans.
Award sizes, project periods, and the total number of awards are not fixed in advance. Instead, NIH indicates that the scale and duration of each award will vary depending on the nature of the proposed work, and that the overall funding level and number of funded projects will depend on the number of applications received, their scientific quality, the requested budgets, and the planned project durations. There is no cost sharing or matching requirement stated for applicants.
Eligibility is broad and includes many types of domestic organizations such as public and private institutions of higher education, nonprofit organizations (including those with or without 501(c)(3) status), state, county, and city or township governments, independent school districts, special district governments, public or Indian housing authorities, federally recognized tribal governments, and other tribal organizations. The announcement also allows for profit organizations (other than small businesses) and small businesses, and it explicitly states that foreign institutions are eligible to apply. It also notes that eligible federal agencies may apply, and that faith based and community based organizations are eligible, which widens the pool beyond traditional academic applicants and supports participation by practice oriented and community anchored entities.
Administratively, the opportunity is associated with several CFDA program areas, reflecting the cross cutting relevance of perinatal mental health to healthcare outcomes, mental health research, substance use research, and child health and development. The posting date is listed as Nov 22, 2006, with multiple receipt dates rather than a single deadline, and the full details were provided through the NIH grants guide link. The announcement was archived on Jun 1, 2009, meaning it is no longer active as written, but it remains a useful reference point for the types of perinatal mental health research NIH has historically prioritized under the R01 mechanism.
Frequently Asked Questions (FAQs)
What is the Women s Mental Health in Pregnancy and the Postpartum Period (R01) opportunity?
It is a National Institutes of Health (NIH) discretionary grant announcement that supports research projects focused on mental health during pregnancy and after childbirth. It uses the NIH Research Project Grant (R01) mechanism and is identified by Funding Opportunity Number PA 07 081.
What is the main goal of this grant opportunity?
The overall aim is to strengthen the evidence base around perinatal mental disorders by funding studies that improve understanding of how these conditions begin, how they progress over time, what biological and social factors shape risk, and which treatments and care approaches work best in real-world settings.
What time period does the opportunity focus on?
The scope is focused on the perinatal window, specifically during pregnancy and the postpartum period after childbirth.
What types of mental health conditions are within scope?
The scope is broad and includes both mood and other mental disorders that occur during pregnancy and postpartum. It explicitly includes attention to both non psychotic conditions (such as perinatal depression and anxiety spectrum problems) and psychotic disorders (including severe postpartum presentations).
Does the FOA include postpartum psychosis or other psychotic disorders?
Yes. The announcement explicitly includes psychotic disorders, including severe postpartum presentations.
How does the opportunity address substance use?
A notable emphasis is placed on research that considers substance use history and substance use disorders. This includes examining how current or lifetime drug abuse, treatment status, and common comorbid conditions may influence the onset, severity, and course of perinatal mental health problems.
What are the main research areas (lanes) NIH encourages under this FOA?
The FOA highlights four main research lanes: (1) clinical course, epidemiology, and risk factors; (2) basic and clinical neuroscience; (3) interventions; and (4) services research.
What kinds of studies fit under clinical course, epidemiology, and risk factors?
This lane can include research on incidence and prevalence, symptom trajectories across pregnancy and postpartum, identification of high-risk groups, and analysis of contributors such as prior psychiatric history, stress exposure, social determinants, obstetric complications, and family context.
What does the basic and clinical neuroscience lane cover?
It supports studies examining biological mechanisms and neurobehavioral processes related to perinatal mental illness. Examples mentioned include hormonal shifts, stress systems, neural circuitry, genetics, other biomarkers, and clinically oriented translational work.
What types of intervention research are included?
The interventions lane can involve developing, testing, or optimizing preventive and therapeutic strategies, including pharmacologic and non pharmacologic approaches. It also includes examining safety, effectiveness, and implementation issues that are specific to pregnancy and lactation contexts.
What is meant by services research in this FOA?
Services research is oriented toward how care is delivered, accessed, coordinated, and paid for. It can include models that integrate screening, referral, and treatment into prenatal, obstetric, pediatric, and community settings, and efforts to improve quality and outcomes.
What grant mechanism does this opportunity use?
This announcement uses the NIH Research Project Grant (R01) mechanism, which is typically intended for larger, hypothesis-driven projects that can support substantial multi-year research programs.
Is there a related NIH opportunity for earlier-stage or pilot work?
Yes. The FOA notes it runs in parallel with a separate announcement of the same scientific scope using the R21 exploratory developmental mechanism (PA 06 377), which signals a companion route for earlier-stage or higher-risk pilot style studies.
Are award size and project length fixed?
No. Award sizes, project periods, and the total number of awards are not fixed in advance. NIH indicates the scale and duration of each award will vary depending on the nature of the proposed work.
What determines how many awards are made and how much funding is available?
The overall funding level and number of funded projects depend on factors including the number of applications received, their scientific quality, the requested budgets, and the planned project durations.
Is cost sharing or matching required?
No cost sharing or matching requirement is stated for applicants.
Who is eligible to apply?
Eligibility is broad and includes many types of organizations. Examples listed include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), and a wide range of government entities (state, county, city or township, independent school districts, special district governments), as well as public or Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized tribal governments and other tribal organizations are included as eligible applicants.
Can for-profit entities apply?
Yes. The announcement allows for profit organizations (other than small businesses) and also allows small businesses.
Are foreign institutions eligible to apply?
Yes. The FOA explicitly states that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The opportunity notes that eligible federal agencies may apply.
Are faith-based and community-based organizations eligible?
Yes. The announcement states that faith based and community based organizations are eligible.
Are there specific CFDA program areas associated with this opportunity?
Yes. The opportunity is associated with several CFDA program areas, reflecting the cross cutting relevance of perinatal mental health to healthcare outcomes, mental health research, substance use research, and child health and development.
When was this FOA posted?
The posting date is listed as Nov 22, 2006.
Does this opportunity have a single application deadline?
No. It is described as having multiple receipt dates rather than a single deadline.
Is this funding opportunity still active?
No. The announcement was archived on Jun 1, 2009, meaning it is no longer active as written. It may still serve as a reference point for the types of perinatal mental health research NIH historically prioritized under the R01 mechanism.
Where were the official details originally published?
The full details were provided through the NIH grants guide link referenced in the announcement.
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