Opportunity Information: Apply for PA 09 175

  • The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Womens Mental Health in Pregnancy and the Postpartum Period (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Apr 24, 2009 and posted on Apr 24, 2009.
  • Applicants must submit their applications by May 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) State governments Public housing authorities/Indian housing authorities City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments For profit organizations other than small businesses County governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Womens Mental Health in Pregnancy and the Postpartum Period (R21) opportunity (Funding Opportunity Number PA 09 175) is a discretionary National Institutes of Health (NIH) grant designed to stimulate exploratory, early-stage research focused on mental health risks and outcomes for women during pregnancy and after childbirth. The core aim is to encourage studies that improve understanding of mental health conditions across the perinatal period, with particular attention to the serious consequences that can occur when illnesses such as postpartum depression or postpartum psychosis go untreated. The announcement notes that widely publicized tragedies have highlighted how severe, untreated symptoms can affect not only the individual mother, but also infants, families, and whole communities. Importantly, the scope is not limited to postpartum months; it explicitly supports research spanning pregnancy through the postpartum period because evidence indicates depression and other mental health concerns are common during pregnancy as well as after delivery.

This FOA is sponsored collaboratively by multiple federal agencies with overlapping interests in maternal and child health and behavioral health: the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the Agency for Healthcare Research and Quality (AHRQ). That mix of sponsors signals that proposed projects can reasonably intersect with mental health research, substance use and addiction issues, maternal and child development, and healthcare quality, access, outcomes, and cost considerations. The associated CFDA program areas listed in the notice reinforce that breadth, including mental health research grants, drug abuse and addiction research, child health and human development extramural research, and research on healthcare costs, quality, and outcomes.

The mechanism of support is the NIH Exploratory/Developmental R21 award, which is typically used for innovative, high-impact ideas that may still be in an earlier stage of development and need initial support to generate feasibility data, refine methods, or open up a new line of investigation. This R21 announcement runs in parallel with a companion opportunity of the same scientific scope that uses the larger R01 Research Project Grant mechanism (PA 09 174). In practice, that means investigators with a concept that is more exploratory or proof-of-concept oriented may find the R21 a better match, while more mature projects with substantial preliminary evidence might align with the R01 pathway.

In terms of funding expectations, the opportunity states that award size and duration may vary because the nature and scope of proposed projects will differ. The published award ceiling is $200,000, and the total number of awards is not fixed in advance. Instead, the final amount awarded and the number of funded projects depend on the mechanism, the volume of applications received, their scientific and technical quality, and the proposed budgets and project periods. Cost sharing or matching is not required, which lowers barriers for applicants that may not have access to non-federal matching funds.

Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (including small businesses), and a wide range of government entities such as state, county, city/township, special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The eligibility listing also explicitly includes groups and institution types that NIH frequently seeks to engage in biomedical and behavioral research, such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and foreign (non-U.S.) entities. Federal agencies are also listed among eligible applicants, which can be relevant for intramural or interagency collaborations where permitted.

Administratively, the FOA was posted and created on April 24, 2009, with an original and current closing date of May 7, 2012, and an archive date of June 7, 2012, meaning it is no longer active for new submissions under that specific announcement. The full archived text was hosted through the NIH grants guide (link provided in the opportunity), and the notice includes NIH Office of Extramural Research contact information for technical difficulties accessing the announcement.

Frequently Asked Questions (FAQs)

What is the Womens Mental Health in Pregnancy and the Postpartum Period (R21) opportunity?

This is a discretionary National Institutes of Health (NIH) grant opportunity designed to stimulate exploratory, early-stage research on mental health risks and outcomes for women during pregnancy and after childbirth. It uses the NIH Exploratory/Developmental R21 mechanism and is identified as Funding Opportunity Number (FON) PA-09-175.

What is the main goal of this funding opportunity?

The core aim is to encourage studies that improve understanding of mental health conditions across the perinatal period (pregnancy through the postpartum period), especially given the serious consequences that can occur when conditions such as postpartum depression or postpartum psychosis go untreated.

Which time period does the scientific scope cover?

The scope explicitly spans pregnancy through the postpartum period. The announcement emphasizes that the focus is not limited to the postpartum months because evidence indicates depression and other mental health concerns are common during pregnancy as well as after delivery.

What mental health issues are highlighted in the announcement?

The announcement specifically mentions postpartum depression and postpartum psychosis and underscores the risks and potentially severe consequences when serious symptoms are untreated.

Why does the announcement emphasize the consequences of untreated illness?

It notes that widely publicized tragedies have highlighted how severe, untreated symptoms can affect not only the mother, but also infants, families, and whole communities.

Which agencies sponsor or collaborate on this FOA?

This FOA is sponsored collaboratively by the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the Agency for Healthcare Research and Quality (AHRQ).

What does the mix of sponsoring agencies suggest about possible research angles?

Because the sponsors include institutes and an agency focused on mental health, substance use/addiction, maternal and child health, and healthcare quality, access, outcomes, and costs, the FOA supports projects that can reasonably intersect with those areas while staying centered on womens mental health during pregnancy and postpartum.

What is the funding mechanism for this opportunity?

The mechanism of support is the NIH Exploratory/Developmental R21 award, which is typically used for innovative, high-impact ideas that are still early in development and need initial support to generate feasibility data, refine methods, or open a new line of investigation.

Is there a related opportunity using a different NIH grant mechanism?

Yes. This R21 announcement runs in parallel with a companion opportunity of the same scientific scope that uses the R01 Research Project Grant mechanism (PA-09-174).

How do I decide whether R21 (PA-09-175) or the companion R01 (PA-09-174) is a better fit?

Based on the description provided, the R21 is positioned for more exploratory or proof-of-concept work, while more mature projects with substantial preliminary evidence may align better with the R01 pathway.

What is the maximum award amount mentioned for this opportunity?

The published award ceiling is $200,000.

Are award size and project duration fixed?

No. The opportunity states that award size and duration may vary because the nature and scope of proposed projects will differ.

Is the number of awards predetermined?

No. The total number of awards is not fixed in advance. The final number of funded projects depends on the mechanism, the volume of applications received, their scientific and technical quality, and the proposed budgets and project periods.

Is cost sharing or matching required?

No. The opportunity states that cost sharing or matching is not required.

What types of organizations are eligible to apply?

Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status); for-profit organizations (including small businesses); and many government entities (state, county, city/township, special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations).

Are minority-serving and community-based institutions included in eligibility?

Yes. The eligibility listing explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities, and faith-based or community-based organizations.

Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are explicitly included among eligible applicants.

Are foreign (non-U.S.) entities eligible to apply?

Yes. The eligibility listing explicitly includes foreign (non-U.S.) entities.

Are federal agencies eligible to apply?

Yes. Federal agencies are listed among eligible applicants, which may be relevant for intramural or interagency collaborations where permitted.

What CFDA program areas are associated with this opportunity?

The notice lists CFDA program areas that reinforce the opportunities breadth, including mental health research grants, drug abuse and addiction research, child health and human development extramural research, and research on healthcare costs, quality, and outcomes.

Is this funding opportunity still open for new submissions?

No. Administratively, it is archived. The FOA was posted and created on April 24, 2009, had an original and current closing date of May 7, 2012, and an archive date of June 7, 2012. That means it is no longer active for new submissions under this specific announcement.

Where was the full opportunity text hosted?

The full archived text was hosted through the NIH Grants Guide, with a link provided in the opportunity materials.

Who is listed as a point of contact for technical issues accessing the announcement?

The notice includes NIH Office of Extramural Research contact information for technical difficulties accessing the announcement.

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