Opportunity Information: Apply for RFA IP 16 00202CONT17
Apply for RFA IP 16 00202CONT17
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Centers for Disease Control and Prevention Annual Estimates of Influenza Vaccine Effectiveness for Preventing Medically Attended Laboratory- Confirmed Influenza in the United States" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.185.
- This funding opportunity was created on Feb 08, 2017.
- Applicants must submit their applications by Apr 10, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
This opportunity is a continuation cooperative agreement from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), focused on producing annual U.S. estimates of influenza vaccine effectiveness (VE). The specific aim is to measure how well seasonal influenza vaccines prevent medically attended, laboratory-confirmed influenza, meaning cases where people become sick enough to seek medical care and have infection confirmed through laboratory testing. In practical terms, the work supported under this grant is designed to generate timely, credible, and comparable VE estimates each flu season so CDC and its partners can better understand vaccine performance, communicate findings to clinicians and the public, and inform public health decisions during and after the season.
The grant is listed under Funding Opportunity Title "Centers for Disease Control and Prevention Annual Estimates of Influenza Vaccine Effectiveness for Preventing Medically Attended Laboratory-Confirmed Influenza in the United States" with Funding Opportunity Number RFA IP 16 00202CONT17. It is categorized as a continuation action, which generally indicates ongoing support for an existing program or network rather than a brand-new initiative. The funding instrument is a cooperative agreement, which is significant because it typically involves substantial federal involvement. Instead of simply funding a project at arm's length, CDC usually works closely with awardees on protocol alignment, data standards, analytic approaches, timelines, and dissemination plans to ensure results are consistent and useful at a national level.
The activity category is Health and the CFDA number is 93.185, placing it within CDC's broader influenza-related public health and surveillance portfolio. The anticipated number of awards is 10, suggesting CDC intended to support multiple sites or partner institutions that collectively contribute data and analyses. Multi-site participation matters for influenza VE because vaccine performance can differ by geography, circulating strains, timing of the season, and population characteristics, and pooling information across multiple sites can improve statistical power and representativeness.
Eligibility is listed as "Others (see text field entitled Additional Information on Eligibility for clarification)." While the specific eligibility details are not included in the source snippet you provided, that phrasing commonly signals that eligibility may be limited to a defined set of organizations, prior recipients, or specific types of entities participating in an established CDC network. Because the opportunity is explicitly a continuation, it is especially likely that CDC expected applications from existing partners already carrying out VE work or able to integrate rapidly into established data collection and laboratory testing processes.
Key administrative dates show a creation date of February 8, 2017, and an original closing date of April 10, 2017, indicating a relatively short application window typical of continuation or time-sensitive public health work. The "Award Ceiling: 0" entry often appears in federal listings when a specific maximum amount is not provided in the summary record or is determined through other budget guidance, negotiations, or continuation funding rules rather than a single fixed cap. In other words, the listing signals that awards were expected, but it does not publicly state a maximum dollar amount per award in the short-form data shown.
Programmatically, the work implied by the title generally involves enrolling patients who seek outpatient medical care for acute respiratory illness, testing them for influenza using accepted laboratory methods, documenting vaccination status, and estimating vaccine effectiveness by comparing vaccination rates among those who test positive for influenza versus those who test negative (a commonly used "test-negative" study design). The outcome of interest is not just influenza infection in general, but medically attended, lab-confirmed influenza, which is an outcome that is more consistently measured across sites and is directly relevant to healthcare utilization and burden. Annual VE estimates are particularly valuable because influenza viruses evolve, vaccine composition changes, and vaccine performance can vary substantially from season to season and among different age groups.
Overall, this CDC cooperative agreement opportunity supports the recurring, nationally important task of producing annual, methodologically consistent estimates of how well seasonal flu vaccines are working in real-world U.S. medical settings. By funding multiple awards and using a cooperative agreement structure, CDC can coordinate efforts across partners, maintain common standards for data and laboratory confirmation, and deliver seasonal vaccine effectiveness information that can guide public health messaging, clinical practice considerations, and broader influenza prevention strategy.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is a CDC cooperative agreement focused on producing annual U.S. estimates of influenza vaccine effectiveness (VE) for each flu season. The work is designed to generate timely, credible, and comparable VE estimates that CDC and partners can use to understand vaccine performance, communicate findings to clinicians and the public, and support public health decisions during and after the season.
What is the official funding opportunity title?
The official title is: "Centers for Disease Control and Prevention Annual Estimates of Influenza Vaccine Effectiveness for Preventing Medically Attended Laboratory-Confirmed Influenza in the United States."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA IP 16 00202CONT17.
Who is the sponsoring agency?
The sponsoring agency is the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC).
What type of funding instrument is used?
The funding instrument is a cooperative agreement. This typically means CDC expects substantial federal involvement in areas such as aligning protocols, setting data standards, guiding analytic approaches, coordinating timelines, and planning dissemination so results are comparable and useful at a national level.
Is this a new program or a continuation?
It is categorized as a continuation action, which generally indicates ongoing support for an existing program, network, or set of sites rather than starting a brand-new initiative.
What is the main purpose of the work funded under this opportunity?
The main purpose is to measure how well seasonal influenza vaccines prevent medically attended, laboratory-confirmed influenza in the United States and to produce annual estimates each flu season using consistent methods.
What does "vaccine effectiveness (VE)" mean in this opportunity?
In this context, vaccine effectiveness refers to how well seasonal influenza vaccines prevent medically attended influenza cases that are confirmed by laboratory testing. The emphasis is on real-world performance in U.S. medical settings rather than vaccine efficacy in a controlled trial.
What exactly is the outcome being measured?
The outcome is medically attended, laboratory-confirmed influenza. That means people who become ill enough to seek medical care and whose influenza infection is confirmed through laboratory testing.
Why focus on "medically attended, laboratory-confirmed" influenza instead of all influenza infections?
This outcome is more consistently measured across sites and is directly relevant to healthcare utilization and disease burden. Laboratory confirmation helps standardize case definition and improves comparability across participating partners and seasons.
How are vaccine effectiveness estimates typically produced under this kind of effort?
Based on the description provided, the work generally involves enrolling patients who seek outpatient medical care for acute respiratory illness, testing them for influenza using accepted laboratory methods, documenting vaccination status, and estimating VE by comparing vaccination rates among those who test positive for influenza versus those who test negative (commonly referred to as a "test-negative" study design).
Why are annual VE estimates needed every flu season?
Influenza viruses evolve, vaccine composition can change, and vaccine performance can vary from season to season and across different age groups. Annual estimates help capture these changes and provide timely information for communication and decision-making.
What is the activity category for this opportunity?
The activity category is Health.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.185, placing it within CDC's broader influenza-related public health and surveillance portfolio.
How many awards were anticipated?
The anticipated number of awards is 10.
Why does CDC anticipate multiple awards for this effort?
Multi-site participation is important because influenza vaccine performance can differ by geography, circulating strains, timing of the season, and population characteristics. Pooling information across multiple sites can improve statistical power and representativeness and help produce more credible national estimates.
Who is eligible to apply?
Eligibility is listed as "Others (see text field entitled Additional Information on Eligibility for clarification)." The specific eligibility details are not included in the information provided here. However, since this is explicitly a continuation action, it suggests eligibility may be limited to a defined set of organizations, prior recipients, or entities able to integrate quickly into an established VE network.
What does it mean that eligibility is listed as "Others"?
It means eligibility is not described in the standard broad categories in the summary shown, and the detailed eligibility requirements were likely provided elsewhere (in the referenced "Additional Information on Eligibility" text field), which is not included in the provided information.
What are the key dates for this opportunity?
The creation date is February 8, 2017, and the original closing date is April 10, 2017.
How long was the application window based on the dates provided?
Based on the creation date (February 8, 2017) and the original closing date (April 10, 2017), the application window appears relatively short, which is consistent with continuation or time-sensitive public health work.
What does "Award Ceiling: 0" mean?
The listing shows "Award Ceiling: 0," which commonly appears in federal listings when a specific maximum award amount is not provided in the summary record. This can indicate that the maximum is determined through other budget guidance, negotiations, or continuation funding rules rather than a single fixed cap stated in the short-form listing.
Does "Award Ceiling: 0" mean no funding will be awarded?
Not necessarily. In this context, it more likely indicates that the summary record does not publicly state a maximum dollar amount per award, not that awards will be zero dollars.
What makes a cooperative agreement different from a standard grant in this case?
The cooperative agreement structure suggests CDC will work closely with awardees, often including involvement in protocol alignment, data standards, analytic approaches, timelines, and dissemination plans. The intent is to ensure VE estimates are consistent, comparable, and useful at a national level.
What kinds of settings are implied for data collection?
The description implies outpatient medical care settings where patients seek care for acute respiratory illness, are tested for influenza, and have vaccination status documented for analysis.
How will the results be used?
The results are intended to help CDC and partners understand vaccine performance, communicate findings to clinicians and the public, and inform public health decisions during and after the influenza season.
Why is laboratory testing emphasized?
Laboratory confirmation supports consistent measurement across sites and improves the credibility and comparability of VE estimates by ensuring influenza cases are identified using accepted testing methods rather than symptoms alone.
What does "timely" mean in the context of this opportunity?
It means producing VE estimates quickly enough within each flu season (and shortly after) to be useful for ongoing public health communication and decision-making, rather than only publishing findings long after the season has ended.
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