Opportunity Information: Apply for RFA HL 12 006
Apply for RFA HL 12 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Consortium of Lung Repair and Regeneration Building the Foundation (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Oct 27, 2010 and posted on Oct 27, 2010.
- Applicants must submit their applications by Feb 10, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education For profit organizations other than small businesses Independent school districts Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Consortium of Lung Repair and Regeneration: Building the Foundation (U01) is a National Heart, Lung, and Blood Institute (NHLBI) cooperative agreement funding opportunity designed to jump-start and organize a collaborative research network focused on how the lung repairs itself after injury and how that process can go wrong in disease. The core idea is to assemble a Lung Repair and Regeneration Consortium (LRRC) made up of multidisciplinary teams that bring fresh expertise, advanced technologies, and ambitious new concepts into a single highly interactive community. Rather than supporting isolated projects, this program is set up to create a connected group of investigators who actively share ideas, data, and resources so that progress in lung regeneration can move faster and more coherently toward new therapeutic approaches for human lung diseases.
This FOA specifically seeks U01 applications that do two major things. First, applicants must apply novel technologies to test innovative hypotheses about the mechanisms that control adaptive (helpful) and maladaptive (harmful) lung repair and regeneration after injury. Importantly, the program expects teams to go beyond basic discovery and include studies that validate whether the proposed mechanisms matter in humans, not only in experimental systems. Second, applicants must develop at least two new tools that can accelerate the broader field of lung regeneration research. These tools can include new reagents, experimental models, imaging approaches, and/or data analysis tools, with the emphasis on creating resources that other researchers can use to push the science forward.
A defining feature of this opportunity is the strong push for true multidisciplinary collaboration. Applicants are encouraged to use the multiple Principal Investigator (multi-PI) structure to reflect integrated team science. Teams must include new collaborations and bring together expertise spanning at least two or more key disciplines, such as developmental biology, stem cell biology, pulmonary medicine, lung injury, physiology, genomics, tissue or bioengineering, nanotechnology, and integrative or systems-level approaches. The goal is to ensure that mechanistic biology, clinical relevance, and enabling technologies are developed side-by-side, rather than in separate silos.
Because this is a cooperative agreement (U01), it also signals an expectation of active coordination with NHLBI and with other funded consortium members. The announcement notes that, after the consortium is assembled, it will include collaborative research support and skills development components administered across the group. In practical terms, that means awardees should be prepared to participate in consortium-wide activities, align with shared goals, and contribute to a culture of openness and resource sharing that strengthens the entire LRRC.
From an administrative and funding standpoint, the opportunity is identified as RFA-HL-12-006 under NIH, within the lung diseases research area (CFDA 93.838). NHLBI anticipated making about six awards, with an estimated total funding level of about $4,000,000. The opportunity did not require cost sharing or matching. Key dates listed include a posted date of October 27, 2010 and an original/current closing date of February 10, 2011, with an archive date of March 13, 2011.
Eligibility was broad and included many organization types, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, state and local governments, tribal governments and tribal organizations, small businesses, for-profit organizations (other than small businesses), independent school districts, public housing authorities/Indian housing authorities, and special district governments. Additional eligible applicants explicitly included Alaska Native and Native Hawaiian Serving Institutions, federal agencies, faith-based and community-based organizations, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), tribally controlled colleges and universities (TCCUs), regional organizations, U.S. territories or possessions, and non-U.S. (foreign) entities.
Overall, this FOA was built to lay the groundwork for a modern lung regeneration research ecosystem: teams that can uncover mechanisms of repair and failed repair, demonstrate relevance to human biology, and deliver practical tools that make the field more capable, faster, and more collaborative, with the long-term aim of enabling new therapies for lung disease.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the Consortium of Lung Repair and Regeneration: Building the Foundation (U01), a National Heart, Lung, and Blood Institute (NHLBI) cooperative agreement designed to launch and organize a collaborative research network focused on lung repair and regeneration after injury.
Which agency is sponsoring the program?
The program is sponsored by the National Heart, Lung, and Blood Institute (NHLBI) within the National Institutes of Health (NIH).
What is the FOA identifier?
The funding opportunity is identified as RFA-HL-12-006.
What funding mechanism is being used?
The mechanism is a U01 cooperative agreement. This indicates an expectation of active coordination with NHLBI and collaboration among funded consortium members, rather than a set of completely independent projects.
What is the program trying to accomplish overall?
The goal is to jump-start and structure a Lung Repair and Regeneration Consortium (LRRC) that brings together multidisciplinary teams to accelerate progress in understanding how lungs repair themselves after injury, how repair can become maladaptive in disease, and how discoveries can be moved more coherently toward new therapeutic approaches for human lung diseases.
What is the Lung Repair and Regeneration Consortium (LRRC)?
The LRRC is a collaborative research network made up of funded multidisciplinary teams. It is intended to be a highly interactive community where investigators share ideas, data, and resources to speed progress in lung regeneration research.
What are the two major required components of a U01 application under this FOA?
Applications are expected to (1) apply novel technologies to test innovative hypotheses about adaptive (helpful) and maladaptive (harmful) lung repair and regeneration after injury, including validation of relevance in humans, and (2) develop at least two new tools that can accelerate the broader lung regeneration field.
What types of scientific questions does the FOA emphasize?
The FOA emphasizes mechanisms that control lung repair and regeneration after injury, including both adaptive repair and maladaptive repair that contributes to disease, and expects innovative hypotheses tested using novel technologies.
Does the FOA expect human relevance, or is basic research alone sufficient?
The FOA explicitly expects teams to go beyond basic discovery by including studies that validate whether proposed mechanisms matter in humans, not only in experimental systems.
How many tools must applicants develop?
Applicants are expected to develop at least two new tools intended to accelerate lung regeneration research for the broader community.
What counts as a "tool" under this FOA?
The FOA describes tools as resources such as new reagents, experimental models, imaging approaches, and/or data analysis tools, with an emphasis on creating resources other researchers can use.
Is this program focused on single-lab projects or team science?
The program is built around team science and a connected consortium model, not isolated projects. It is designed to create a coordinated group of investigators who share ideas, data, and resources.
Is multidisciplinary collaboration required?
A strong push for true multidisciplinary collaboration is a defining feature of this opportunity. Teams are expected to integrate expertise spanning at least two or more key disciplines.
Does the FOA encourage a multiple Principal Investigator (multi-PI) structure?
Yes. Applicants are encouraged to use the multiple Principal Investigator (multi-PI) structure to reflect integrated team science.
What disciplines are specifically mentioned as relevant to this FOA?
The FOA lists examples including developmental biology, stem cell biology, pulmonary medicine, lung injury, physiology, genomics, tissue or bioengineering, nanotechnology, and integrative or systems-level approaches.
Are new collaborations expected?
Yes. Teams must include new collaborations and bring fresh expertise and advanced technologies into the consortium.
What does the cooperative agreement aspect mean for awardees?
Because this is a U01 cooperative agreement, awardees should be prepared for active coordination with NHLBI and with other consortium members, participation in consortium-wide activities, alignment with shared goals, and contributions to openness and resource sharing.
Will there be consortium-wide components beyond individual projects?
Yes. The announcement notes that, after the consortium is assembled, it will include collaborative research support and skills development components administered across the group.
How many awards were anticipated?
NHLBI anticipated making about six awards.
What was the estimated total funding level?
The estimated total funding level was about $4,000,000.
Is cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
What is the CFDA number and research area associated with this opportunity?
The opportunity is within the lung diseases research area and is associated with CFDA 93.838.
When was the opportunity posted?
The posted date listed is October 27, 2010.
What was the closing date for applications?
The original/current closing date listed is February 10, 2011.
When was the opportunity archived?
The archive date listed is March 13, 2011.
What types of organizations were eligible to apply?
Eligibility was broad and included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, state and local governments, tribal governments and tribal organizations, small businesses, for-profit organizations (other than small businesses), independent school districts, public housing authorities/Indian housing authorities, and special district governments.
Are minority-serving institutions included as eligible applicants?
Yes. The eligibility list explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and tribally controlled colleges and universities (TCCUs).
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations were explicitly included as eligible applicants.
Are federal agencies eligible to apply?
Yes. Federal agencies were explicitly listed among the additional eligible applicants.
Are non-U.S. (foreign) entities eligible to apply?
Yes. Non-U.S. (foreign) entities were explicitly listed as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions were explicitly included as eligible applicants.
What is the long-term intended impact of this FOA?
The FOA is intended to lay the groundwork for a modern lung regeneration research ecosystem by enabling teams to uncover repair and failed-repair mechanisms, demonstrate relevance to human biology, and deliver practical tools and shared resources that help the field move faster toward new therapies for lung disease.
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