Opportunity Information: Apply for RFA HL 15 028

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Creating Asthma Empowerment Collaborations to Reduce Childhood Asthma Disparities (U34)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
  • This funding opportunity was created on Dec 9, 2014 and posted on Dec 9, 2014.
  • Applicants must submit their applications by Feb 20, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $225,000.00 in funding.
  • The number of recipients for this funding is limited to 9 candidate(s).
  • Eligible applicants include: City or township governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Small businesses Public housing authorities/Indian housing authorities State governments For profit organizations other than small businesses Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

Creating Asthma Empowerment Collaborations to Reduce Childhood Asthma Disparities (U34) is an NIH cooperative agreement grant opportunity designed specifically for planning, not running, a full clinical trial. The central goal is to help investigators build and refine a strong, trial-ready Asthma Care Implementation Program (ACIP) for children who are at high risk of poor asthma outcomes, especially in communities where asthma-related disparities are most pronounced. The emphasis is on taking interventions that already have evidence behind them and translating them into real-world community practice, rather than inventing entirely new interventions from scratch.

A key requirement is that the proposed ACIP must be multi-sector and integrated, meaning it cannot sit only inside the clinic or only inside the home. Instead, applicants are expected to assemble a comprehensive program that combines proven interventions across a system of care for children, drawing from at least one of these sectors: medical care, family, home, and community. In practice, that means an applicant might combine clinical approaches (like guideline-based care and medication management support) with family-focused education or coaching, home-based environmental trigger reduction strategies, and community supports such as school or neighborhood-based linkages to services. The program is expected to function as a coordinated package rather than a set of disconnected activities.

During the U34 project period, investigators must conduct a community needs assessment to confirm what children in their target U.S. community actually need and what barriers exist to achieving good asthma outcomes. The announcement makes it clear that the initial ACIP plan may need to be modified based on what is learned through that assessment. As those interventions are refined, the clinical trial concept must also evolve in parallel. In other words, this planning award is intended to support the work of adjusting the intervention package and simultaneously developing a complete, trial-ready protocol that can realistically test the refined ACIP in the community setting.

Another major deliverable is partnership-building and resource commitment. Applicants are expected to either strengthen existing cross-sector relationships or bring in new collaborators from each relevant sector (medical care, family supports, home-focused services, and community organizations). These partners should be in a position to identify what concrete resources they can commit to the ACIP, since the long-term aim is not just to test a program once, but to implement it in a way that could be maintained and scaled. The cooperative agreement structure signals that NIH expects substantial interaction around planning, coordination, and readiness for the later implementation phase.

By the end of the U34, teams should be positioned to apply for the next-stage funding mechanism, a U01 (referenced as RFA HL 17 001 in the description), which would support conducting the actual clinical trial, evaluating sustainability, and defining best practices for implementing effective interventions for children at high risk of poor asthma outcomes. Put simply, the U34 is the runway: it funds the groundwork needed to ensure the later trial is feasible, community-aligned, collaborative, and scientifically solid.

Administratively, this opportunity is listed as RFA HL 15 028 under the NIH, with activity aligned to lung diseases research (CFDA 93.838). NIH anticipated up to 9 awards, with an estimated total funding amount of about $3,000,000 and an award ceiling of $225,000. There is no cost sharing or matching requirement. The original posting date was December 9, 2014, with a closing date of February 20, 2015, and it was later archived in March 2015.

Eligibility is broad and includes many types of U.S.-based organizations and governments, such as state, county, city or township governments, independent school districts, special district governments, public housing authorities/Indian housing authorities, tribal governments and tribal organizations, nonprofits (both 501(c)(3) and non-501(c)(3)), small businesses and other for-profit organizations, and public or private institutions of higher education. The eligibility notes also highlight specific institution types and community-based entities that may apply, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, faith-based and community-based organizations, regional organizations, and eligible federal agencies. Non-U.S. entities and non-U.S. components of U.S. organizations are not eligible to apply, although foreign components (as NIH defines them in policy) may be permitted.

The full announcement was linked through the NIH grants site at http://grants.nih.gov/grants/guide/rfa files/RFA HL 15 028.html, and the provided contact for access or technical issues was the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).

FAQs: Creating Asthma Empowerment Collaborations to Reduce Childhood Asthma Disparities (U34)

What is the "Creating Asthma Empowerment Collaborations to Reduce Childhood Asthma Disparities (U34)" opportunity?

It is an NIH cooperative agreement planning grant (U34) focused on preparing a trial-ready Asthma Care Implementation Program (ACIP) to reduce childhood asthma disparities in U.S. communities where children are at high risk of poor asthma outcomes.

Is this U34 funding meant to run a full clinical trial?

No. This U34 is designed specifically for planning and preparing for a later clinical trial, not for conducting the full trial itself.

What is the central goal of this planning award?

The main goal is to help investigators build and refine a strong, trial-ready ACIP by translating interventions that already have evidence behind them into real-world community practice, especially in communities with pronounced asthma-related disparities.

Does the ACIP need to be based on existing evidence?

Yes. The emphasis is on taking interventions that already have evidence supporting them and translating them into community practice, rather than creating entirely new interventions from scratch.

What does "multi-sector and integrated" mean for the proposed ACIP?

It means the program cannot exist only inside a clinic or only inside the home. Applicants are expected to assemble a coordinated package that combines proven interventions across a system of care for children, drawing from at least one of these sectors: medical care, family, home, and community.

Which sectors can be included in the ACIP?

The ACIP can draw from these sectors: medical care, family, home, and community. The program is expected to combine interventions across sectors into an integrated package.

Can you give examples of the kinds of components an ACIP might include?

Examples described include combining clinical approaches such as guideline-based care and medication management support with family-focused education or coaching, home-based environmental trigger reduction strategies, and community supports such as school or neighborhood-based linkages to services.

Is it acceptable to propose separate, disconnected activities across sectors?

No. The ACIP is expected to function as a coordinated package rather than a set of disconnected activities.

What is required during the U34 project period?

Investigators must conduct a community needs assessment to confirm the needs of children in the target U.S. community and identify barriers to achieving good asthma outcomes.

Does the needs assessment affect the ACIP plan?

Yes. The announcement states the initial ACIP plan may need to be modified based on what is learned through the community needs assessment.

What happens to the clinical trial concept during the U34 planning work?

As the interventions are refined based on community needs, the clinical trial concept must evolve in parallel. The U34 supports developing a complete, trial-ready protocol that can realistically test the refined ACIP in the community setting.

What are the partnership expectations for applicants?

Applicants are expected to strengthen existing cross-sector relationships or bring in new collaborators from each relevant sector (medical care, family supports, home-focused services, and community organizations).

Do partners need to commit resources?

Yes. Partners should be able to identify what concrete resources they can commit to the ACIP, supporting the longer-term aim of implementing the program in a way that could be maintained and scaled.

Why is this a cooperative agreement (U34) rather than a standard grant?

The cooperative agreement structure indicates NIH expects substantial interaction around planning, coordination, and readiness for the later implementation phase.

What is the next-stage funding mechanism after the U34?

By the end of the U34, teams should be positioned to apply for a U01 (referenced as RFA HL 17 001 in the description) to conduct the actual clinical trial, evaluate sustainability, and define best practices for implementation.

What is the relationship between the U34 and the later U01?

The U34 is the runway that funds the groundwork to ensure the later trial is feasible, community-aligned, collaborative, and scientifically solid, while the U01 would support running the clinical trial and related evaluation work.

What is the NIH announcement number for this opportunity?

The opportunity is listed as RFA HL 15 028.

What NIH research area is this opportunity aligned with?

It is aligned to lung diseases research and is associated with CFDA 93.838.

How many awards were anticipated and what was the estimated total funding?

NIH anticipated up to 9 awards, with an estimated total funding amount of about $3,000,000.

What is the maximum (ceiling) award amount?

The award ceiling listed is $225,000.

Is cost sharing or matching required?

No. There is no cost sharing or matching requirement.

When was this opportunity posted and when did it close?

The original posting date was December 9, 2014, and the closing date was February 20, 2015. It was later archived in March 2015.

Who is eligible to apply?

Eligibility is broad and includes many types of U.S.-based organizations and governments, including state, county, city or township governments; independent school districts; special district governments; public housing authorities/Indian housing authorities; tribal governments and tribal organizations; nonprofits (501(c)(3) and non-501(c)(3)); small businesses and other for-profit organizations; and public or private institutions of higher education.

Are specific institution types and community-based entities mentioned as eligible?

Yes. The eligibility notes highlight entities such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, faith-based and community-based organizations, regional organizations, and eligible federal agencies.

Are non-U.S. entities eligible to apply?

No. Non-U.S. entities and non-U.S. components of U.S. organizations are not eligible to apply.

Are foreign components allowed?

Foreign components (as NIH defines them in policy) may be permitted, even though non-U.S. entities and non-U.S. components of U.S. organizations are not eligible to apply.

Where can applicants find the full announcement?

The full announcement was linked through the NIH grants site at http://grants.nih.gov/grants/guide/rfa files/RFA HL 15 028.html.

Who should be contacted for access or technical issues with the announcement?

The provided contact for access or technical issues is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

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