Opportunity Information: Apply for W81XWH 13 NFRP CTA
Apply for W81XWH 13 NFRP CTA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis Clinical Trial Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on May 3, 2013 and posted on May 3, 2013.
- Applicants must submit their applications by Jul 11, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,900,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Neurofibromatosis Clinical Trial Award (FY13 NFRP CTA) is a Department of the Army (USAMRAA/CDMRP) funding opportunity aimed at reducing the real-world clinical burden of neurofibromatosis (NF). The larger program vision is to decrease the clinical impact of NF by backing innovative, high-impact work that opens new directions in the field, tackles neglected research needs, and strengthens multidisciplinary and multi-institutional collaboration. In practice, the program is meant to move promising ideas toward patient benefit, support translational and clinical research that bridges bench to bedside, help develop the next generation of NF investigators, and maintain a balanced research portfolio covering NF1, NF2, and schwannomatosis.
This particular award mechanism is specifically for clinical trials and is intended to support studies that could meaningfully improve the treatment or management of NF. Supported trials can evaluate new products and interventions, including pharmacologic agents (drugs and biologics), medical devices, clinical guidance approaches, and emerging technologies. The scope is broad: proposals can range from smaller proof-of-concept efforts (such as pilot studies, first-in-human trials, or Phase 0 studies) designed to test feasibility and inform later-stage trial design, all the way through larger trials intended to determine efficacy in relevant patient populations. A key restriction is that funding under this mechanism must be used to support an actual clinical trial; it cannot be used for preclinical research studies.
The FY13 NFRP strongly encouraged applications that directly address high-priority needs in the NF community, especially within one or more identified Areas of Emphasis. These included cognitive and social dysfunction associated with NF, drug discovery for NF treatment, and understanding the heterogeneity of neurofibromas and other NF-related tumors using modern approaches such as genomics, epigenetics, and systems biology. Additional emphasis areas were manifestations of NF after adolescence, development of novel disease markers (including imaging- and proteomics-based markers), and pain in the context of NF. While the Clinical Trial Award is focused on trials rather than discovery work, these emphasis areas signal the kinds of clinical problems and translational directions the program viewed as especially urgent and impactful.
Administratively, this was a discretionary funding opportunity (Funding Opportunity Number W81XWH-13-NFRP-CTA) offered as a cooperative agreement and/or grant within the Science and Technology and other Research and Development category, tied to CFDA 12.420 (Military Medical Research and Development). The program anticipated making about two awards, with an estimated total funding level of approximately $2.9 million, and it did not require cost sharing or matching. Eligibility was listed as unrestricted (open to any type of entity, subject to any additional clarifications in the full announcement). The opportunity was posted May 3, 2013, with a closing date of July 11, 2013, and it was later archived on August 10, 2013. For applicants needing assistance accessing the full announcement, the notice directed them to contact the CDMRP Help Desk (301-682-5507).
FAQs: DoD Neurofibromatosis Clinical Trial Award (FY13 NFRP CTA)
What is the FY13 NFRP Clinical Trial Award?
The DoD Neurofibromatosis Clinical Trial Award (FY13 NFRP CTA) is a funding opportunity from the Department of the Army (USAMRAA/CDMRP) intended to reduce the real-world clinical burden of neurofibromatosis (NF) by supporting clinical trials that could meaningfully improve treatment or management of NF.
Which agency and program are behind this opportunity?
This opportunity was offered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP), within the broader DoD Neurofibromatosis Research Program (NFRP).
What is the broader goal of the DoD Neurofibromatosis Research Program (NFRP)?
The program vision is to decrease the clinical impact of NF by backing innovative, high-impact work that opens new directions in the field, addresses neglected research needs, and strengthens multidisciplinary and multi-institutional collaboration. The program aims to move promising ideas toward patient benefit, support translational and clinical research bridging bench to bedside, help develop the next generation of NF investigators, and maintain a balanced portfolio spanning NF1, NF2, and schwannomatosis.
What kind of projects does the Clinical Trial Award support?
This award mechanism is specifically intended to support an actual clinical trial evaluating an intervention that could improve the treatment or management of NF.
Does the award require that the proposed work be a clinical trial?
Yes. A key restriction is that funding under this mechanism must be used to support an actual clinical trial. It cannot be used for preclinical research studies.
What types of interventions or products can be evaluated in supported trials?
Supported trials can evaluate new products and interventions, including pharmacologic agents (drugs and biologics), medical devices, clinical guidance approaches, and emerging technologies.
What stages or sizes of clinical trials are within scope?
The scope includes both smaller proof-of-concept efforts (such as pilot studies, first-in-human trials, or Phase 0 studies) intended to test feasibility and inform later-stage trial design, and larger trials intended to determine efficacy in relevant patient populations.
Is preclinical or discovery research allowed under this award?
No. The Clinical Trial Award is designed for clinical trials, and funding under this mechanism cannot be used for preclinical research studies.
What neurofibromatosis conditions are covered by the program?
The broader NFRP program aims to maintain a balanced research portfolio that covers NF1, NF2, and schwannomatosis.
What were the identified Areas of Emphasis for FY13 NFRP?
The FY13 NFRP strongly encouraged applications addressing high-priority needs in the NF community, particularly within one or more Areas of Emphasis. These included: cognitive and social dysfunction associated with NF; drug discovery for NF treatment; understanding heterogeneity of neurofibromas and other NF-related tumors using approaches such as genomics, epigenetics, and systems biology; manifestations of NF after adolescence; development of novel disease markers (including imaging- and proteomics-based markers); and pain in the context of NF.
If this mechanism is for clinical trials, why do the Areas of Emphasis mention discovery topics?
While the Clinical Trial Award is focused on trials rather than discovery work, the Areas of Emphasis indicate the clinical problems and translational directions the program viewed as especially urgent and impactful.
What is the Funding Opportunity Number for this award?
The Funding Opportunity Number is W81XWH-13-NFRP-CTA.
What is the award type (grant vs. cooperative agreement)?
The notice described this as a discretionary funding opportunity offered as a cooperative agreement and/or grant.
What category does this funding opportunity fall under?
It was listed under the Science and Technology and other Research and Development category.
What CFDA number is associated with this opportunity?
This opportunity was tied to CFDA 12.420 (Military Medical Research and Development).
How much funding was anticipated and how many awards were expected?
The program anticipated making about two awards, with an estimated total funding level of approximately $2.9 million.
Was cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
Who was eligible to apply?
Eligibility was listed as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement.
When was the opportunity posted and when did it close?
The opportunity was posted on May 3, 2013, and the closing date was July 11, 2013.
Is this opportunity still open?
No. The opportunity was later archived on August 10, 2013.
Where can applicants get help accessing the full announcement?
The notice directed applicants needing assistance accessing the full announcement to contact the CDMRP Help Desk at 301-682-5507.
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