DoD Ovarian Cancer Translational Pilot Award | Apply Online

Opportunity Summary:

The DoD Ovarian Cancer Translational Pilot Award (OCRP TPA) was a FY10 funding opportunity from the Department of the Army, administered through USAMRAA under the Ovarian Cancer Research Program, designed to push ovarian cancer research ideas toward real-world clinical use. The award specifically targeted innovative translational pilot projects that tackle a critical problem or question in ovarian cancer and are positioned to speed up the path from promising concepts to practical applications that could ultimately benefit patients. A central expectation was that proposed work would serve as a catalyst, meaning it should challenge existing assumptions, open up new directions, or meaningfully expand current approaches in the field rather than simply extending routine or incremental research.

A defining feature of this mechanism was its emphasis on early-stage translation in either direction: laboratory-to-clinic (for example, taking a biological discovery toward a diagnostic, prognostic, preventive, or therapeutic approach) or clinic-to-laboratory (for example, using clinical observations to drive focused mechanistic studies or to explain patient outcomes, responses, or resistance patterns). The program recognized that strong translational ideas can originate from many sources, including a new laboratory finding, careful synthesis of the scientific literature, population-based or epidemiologic studies, unexpected or novel results observed during a clinical trial, or insights arising from a clinician's firsthand experience with patients, including anecdotal patterns that warrant systematic investigation. In other words, applicants were encouraged to start with an important real problem and propose a well-reasoned pilot effort that could set up the next steps toward clinical impact.

Unlike many research grants, preliminary data were not required for this award, which lowered the barrier for high-risk, high-reward pilot concepts that are not yet supported by extensive prior results. At the same time, preliminary data were allowed if available. Because the program was intentionally open to early translational ideas, reviewers were expected to rely heavily on the strength of the scientific rationale, the logic of the proposed approach, and the clarity of how the pilot work would move an idea along the translational pathway. In practice, that means a competitive application would clearly explain the unmet need or critical bottleneck in ovarian cancer, why the proposed concept is compelling, what specific pilot aims will be completed within the project period, and how success would position the work for subsequent development, validation, or clinical testing.

Administratively, this opportunity was posted January 27, 2010 (Funding Opportunity Number W81XWH-10-OCRP-TPA) and closed June 10, 2010, with an archive date of July 10, 2010. The funding instrument type allowed for either a cooperative agreement or a grant, and it fell under the Science and Technology/Research and Development activity category. The program anticipated making about 12 awards, supported by an estimated total funding amount of $4.1 million, and it did not require cost sharing or matching funds. Eligibility was listed as unrestricted, meaning it was broadly open to different types of applicant organizations, subject to any additional eligibility clarifications in the full announcement. For assistance, the announcement provided contacts for CDMRP program announcement help and eReceipt support through the CDMRP Help Desk.

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