Opportunity Information: Apply for RFA AI 09 023

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Enterics Research Investigational Network Cooperative Research Centers (U19)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.856 Microbiology and Infectious Diseases Research.
  • This funding opportunity was created on Jun 25, 2009 and posted on Jun 25, 2009.
  • Applicants must submit their applications by Nov 17, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $5,400,000.00 to eligible and selected applicants.
  • Eligible applicants include: Native American tribal governments (Federally recognized) County governments Private institutions of higher education Public and State controlled institutions of higher education Independent school districts City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Special district governments Public housing authorities/Indian housing authorities State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Enterics Research Investigational Network (ERIN) Cooperative Research Centers (U19) funding opportunity (RFA-AI-09-023) was issued by the National Institute of Allergy and Infectious Diseases (NIAID) within the National Institutes of Health (NIH) to create a coordinated, multi-center research network focused on enteric disease agents, including enteric toxins. The central goal is to reduce the disconnect that often exists between basic laboratory discoveries, translational development work, and clinical research by supporting integrated teams that can move ideas and findings more efficiently across those stages. In practice, the program is meant to bring together investigators who study the biology and pathogenesis of enteric pathogens and toxins with those who can translate that knowledge into diagnostics, therapeutics, vaccines, or other interventions, and then evaluate those advances in clinical or clinically relevant settings.

The mechanism used is a multi-project Cooperative Agreement (U19), which signals two important features. First, applicants are expected to propose a center-style structure made up of multiple, interrelated projects that collectively pursue a common scientific theme rather than a single independent research project. Second, because it is a cooperative agreement, NIAID program staff are expected to have an active collaborative role in the network. This is not simply a standard grant where the agency provides funding and steps back; the design emphasizes coordinated network activities, shared priorities, and cooperative interactions between the funded centers and NIAID staff to ensure the program functions as a cohesive national effort rather than a set of isolated awards.

Funding for this opportunity was planned at an estimated total of $5.4 million in total costs for fiscal year 2010, with an anticipated 3 to 5 new awards. The opportunity falls under the Health funding activity category and is associated with CFDA 93.856 (Microbiology and Infectious Diseases Research). There is no cost sharing or matching requirement indicated, which typically lowers barriers for applicants by not requiring non-federal dollars to be committed as a condition of award.

Eligibility is broad and includes a wide range of domestic organizational types, reflecting the network and center-based intent. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), small businesses, for-profit organizations other than small businesses, and multiple levels of government entities (state, county, city/township, special district governments, and certain housing authorities). The eligibility list also explicitly includes tribal governments and tribal organizations (including those other than federally recognized tribal governments), as well as U.S. territories or possessions and regional organizations. In addition, the announcement highlights inclusion of institutions serving specific populations, such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, along with eligible federal government agencies where applicable.

Key timeline details show the opportunity was posted and created on June 25, 2009, with an original and current closing date of November 17, 2009, and an archive date of December 18, 2009. The full announcement was hosted on the NIH grants site, and the provided contact pathway for access or technical issues routed inquiries through the NIH Office of Extramural Research (OER) webmaster.

Overall, this FOA is best understood as an effort by NIAID to stand up a structured, collaborative network of Cooperative Research Centers dedicated to enteric pathogens and toxins, specifically designed to encourage cross-disciplinary integration and active coordination across multiple sites, with the expectation that the funded centers would work together and with NIAID staff to accelerate the movement of enterics research from foundational discovery into tangible clinical and public health impact.

Frequently Asked Questions (FAQs)

What is the ERIN Cooperative Research Centers (U19) funding opportunity?

The Enterics Research Investigational Network (ERIN) Cooperative Research Centers (U19) is a National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) funding opportunity intended to create a coordinated, multi-center research network focused on enteric disease agents, including enteric toxins. The specific funding opportunity is identified as RFA-AI-09-023.

What is the primary goal of this program?

The central goal is to reduce the disconnect that often exists between basic laboratory discoveries, translational development work, and clinical research. The program supports integrated teams designed to move ideas and findings more efficiently across these stages.

What research areas does ERIN focus on?

The network is focused on enteric disease agents, including enteric pathogens and enteric toxins, with an emphasis on understanding biology and pathogenesis and translating that knowledge into practical interventions.

What kinds of outcomes or products is the program trying to advance?

The program is designed to help translate enterics research into diagnostics, therapeutics, vaccines, or other interventions, and to support evaluation of these advances in clinical or clinically relevant settings.

What is the funding mechanism for this opportunity?

The mechanism is a multi-project Cooperative Agreement (U19). This indicates a center-style, multi-component structure and an expectation of coordinated collaboration with NIAID program staff.

How is a U19 different from a standard research grant?

A U19 is a cooperative agreement rather than a standard grant. Applicants are expected to propose multiple, interrelated projects that align under a common scientific theme (a center-style structure). In addition, NIAID program staff are expected to have an active collaborative role, emphasizing coordinated network activities and shared priorities across funded centers.

What does a "center-style" structure mean for applicants?

It means applicants are expected to propose multiple, interrelated projects that collectively pursue a common scientific theme, rather than proposing a single standalone research project.

What does "cooperative" mean in the context of this program?

It means the program is designed for active coordination: funded centers are expected to participate in cooperative interactions with each other and with NIAID staff so the program functions as a cohesive national effort rather than isolated awards.

Who is the sponsoring agency for this opportunity?

The opportunity was issued by the National Institute of Allergy and Infectious Diseases (NIAID) within the National Institutes of Health (NIH).

What is the estimated total funding available?

The planned estimate was $5.4 million in total costs for fiscal year 2010.

How many awards were anticipated?

The funding opportunity anticipated making 3 to 5 new awards.

What is the funding activity category?

The opportunity is under the Health funding activity category.

What CFDA number is associated with this opportunity?

This opportunity is associated with CFDA 93.856, Microbiology and Infectious Diseases Research.

Is cost sharing or matching required?

No. The information provided indicates there is no cost sharing or matching requirement.

What types of organizations are eligible to apply?

Eligibility is broad and includes many domestic organizational types, including:

  • Public and private institutions of higher education
  • Nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations)
  • Small businesses
  • For-profit organizations other than small businesses
  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Certain housing authorities
  • Tribal governments
  • Tribal organizations (including those other than federally recognized tribal governments)
  • U.S. territories or possessions
  • Regional organizations
  • Eligible federal government agencies (where applicable)

Are organizations that serve specific populations explicitly included in eligibility?

Yes. The eligibility information explicitly highlights inclusion of institutions and organizations such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations.

When was this funding opportunity posted?

The opportunity was posted (and created) on June 25, 2009.

What was the application closing date?

The original and current closing date listed was November 17, 2009.

When was the opportunity archived?

The archive date listed was December 18, 2009.

Where was the full announcement hosted?

The full announcement was hosted on the NIH grants site.

Who should be contacted for access or technical issues related to the announcement?

The provided contact pathway for access or technical issues routed inquiries through the NIH Office of Extramural Research (OER) webmaster.

How should this FOA be understood at a high level?

It is an effort by NIAID to stand up a structured, collaborative network of Cooperative Research Centers dedicated to enteric pathogens and toxins, intentionally designed to encourage cross-disciplinary integration and active coordination across multiple sites to accelerate movement from foundational discovery to clinical and public health impact.

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