Epigenetic Approaches in Cancer Epidemiology (R01) | Apply Online

Opportunity Summary:

The NIH funding opportunity PA-07-298, titled "Epigenetic Approaches in Cancer Epidemiology (R01)," supports population-based cancer epidemiology studies that focus specifically on DNA methylation as an epigenetic marker. The central aim is to encourage research that uses epidemiologic designs and human population data to better understand how patterns of DNA methylation relate to cancer risk, development, prevention, or other cancer-related outcomes. In practical terms, the announcement is looking for projects that treat DNA methylation markers as measurable indicators in people or populations and use them to answer epidemiology questions about cancer, rather than purely laboratory or mechanistic work in isolation.

This announcement uses the NIH Research Project Grant (R01) mechanism, meaning it is intended for more mature, hypothesis-driven projects that can support a substantial research plan over multiple years. The FOA explicitly notes that it runs alongside a parallel announcement with the same scientific scope but a different grant mechanism: PA-07-299, which uses the R21 mechanism for developmental or exploratory studies. Applicants who have pilot-level ideas or early-stage feasibility work might be a better fit for the R21 companion, while more established projects with stronger preliminary data and a clear plan for execution would generally align with the R01 track described here.

Funding levels and the number of awards are not fixed in advance. Instead, NIH indicates that awards will depend on the availability of funds and, importantly, the volume and quality of applications received. Because proposed studies can vary widely in design, scale, duration, and cost (for example, large cohort-based methylation profiling versus smaller nested case-control analyses within existing cohorts), the announcement anticipates that both the budget size and project period will differ from one award to another. In other words, there is no single standard award amount promised; the final totals are shaped by the scientific merit, requested costs, and practical scope of each application, as well as overall program resources.

The opportunity is categorized as a discretionary grant in the health and education-related funding activity space and is associated with CFDA number 93.393 (Cancer Cause and Prevention Research). It does not require cost sharing or matching funds, which reduces barriers for organizations that may not have non-federal funds available to contribute. The sponsoring agency is the National Institutes of Health.

Eligibility is broad and includes many common research-performing organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (both those with and without 501(c)(3) status, with the noted caveat that some categories are defined as "other than institutions of higher education"), for-profit organizations (other than small businesses), and small businesses. The announcement also lists an "Others" category with direction to consult the full text for clarification, which typically covers additional entity types permitted under NIH policy. Foreign institutions are explicitly eligible to apply, which is a notable point for international research teams or collaborations that want to lead an NIH application rather than only participate as subawardees.

From an administrative standpoint, the FOA was originally posted on January 16, 2007, and it used multiple receipt dates rather than a single deadline, meaning NIH accepted applications on recurring standard submission cycles during the active period of the announcement. The archive date is listed as February 2, 2010, indicating the specific announcement is no longer active as written, though similar topic areas may reappear in newer NIH funding calls.

Applicants are directed to the full announcement for complete details at the NIH grants guide link: http://grants.nih.gov/grants/guide/pa-files/PA-07-298.html. For access or technical issues related to the announcement posting, the contact provided is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV), which is a logistical contact rather than a scientific program contact.

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