Opportunity Information: Apply for PAR 09 240
Apply for PAR 09 240
- The National Institutes of Health in the environment health income security and social services sector is offering a public funding opportunity titled "Genetic and Genomic Analysis of Xenopus (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.242 Mental Health Research Grants 93.837 Cardiovascular Diseases Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.867 Vision Research.
- This funding opportunity was created on Jul 27, 2009 and posted on Jul 27, 2009.
- Applicants must submit their applications by Sep 30, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Special district governments For profit organizations other than small businesses Small businesses County governments City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts State governments Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH funding opportunity "Genetic and Genomic Analysis of Xenopus (R01)" (PAR-09-240) was a discretionary, investigator-initiated research grant solicitation aimed at strengthening and expanding the use of Xenopus (frog) as a vertebrate model organism for biomedical research. It was issued jointly by multiple NIH Institutes and Centers, including NICHD, NHLBI, NIDCD, NIDCR, NIEHS, NIGMS, NIMH, NINDS, along with the Trans-NIH Xenopus Working Group, reflecting a broad interest in Xenopus-based approaches across development, physiology, neuroscience, mental health, environmental health, and other disease-relevant areas. The core idea was to fund projects that either create high-value genetic/genomic tools and community resources for Xenopus researchers, or that apply newer genetic and genomic methods to uncover genes, pathways, and phenotypes in ways that push the field forward, especially when the approaches had not been widely used in Xenopus before.
Scientifically, the FOA emphasized research that advances the detection and characterization of genes and biological pathways and links them to observable phenotypes. Priority areas included developmental biology and organogenesis, as well as fundamental cell biology topics such as cell division, signaling, and cell migration. In practical terms, applicants were encouraged to propose work that increases what the Xenopus community can do at scale and with greater precision: building or improving genetic resources, enhancing genomic analysis capabilities, and enabling more informative phenotype discovery and interpretation. A key theme was community benefit and high priority resources, meaning the most responsive applications were likely those that produced broadly useful tools, datasets, or methods that other Xenopus labs could adopt rather than narrowly tailored, one-off capabilities.
The mechanism of support was the NIH Research Project Grant (R01), which is typically used for substantial, hypothesis-driven or resource-enabling projects with a multi-year scope. This FOA ran in parallel with two companion announcements that had the same scientific scope but different grant mechanisms: an R03 small grant option (PAR-09-242) and an R21 exploratory/developmental option (PAR-09-241). That structure gave investigators multiple entry points depending on project maturity, scale, and risk profile, while keeping the overall program goal consistent: accelerating Xenopus genetics and genomics as a platform for biomedical discovery.
From an administrative and eligibility standpoint, the opportunity was widely open. Eligible applicants included public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses, though the FOA itself is not the SBIR/STTR mechanism), and a wide range of governmental and community-based entities such as state and local governments, independent school districts, public housing authorities, special district governments, and tribal governments and organizations. The eligibility list also explicitly included groups and institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, faith-based/community-based organizations, regional organizations, and U.S. territories or possessions. Importantly, non-U.S. entities (foreign organizations) were also listed as eligible, indicating the NIH’s willingness to support strong Xenopus genetics/genomics work wherever it was best positioned to be done, consistent with NIH policies. There was no cost sharing or matching requirement.
Key dates show that this was a time-limited program announcement: it was posted and created on July 27, 2009, with an original and final closing date of September 30, 2011, and it was archived on October 31, 2011. The CFDA numbers associated with the FOA span several NIH program areas (for example, environmental health, oral diseases, deafness and communication disorders, mental health, cardiovascular diseases, neurosciences/neurological disorders, general biomedical research/training, and child health and human development), which underscores the cross-cutting expectation that improved Xenopus genetic and genomic capabilities would have downstream impact across many biomedical domains.
In short, PAR-09-240 was designed to catalyze the next generation of Xenopus genetics and genomics by funding R01-level projects that either build enabling tools and shared resources for the field or use emerging genomic approaches to reveal new gene-function and pathway-phenotype relationships in development and core cellular processes.
Frequently Asked Questions (FAQs): NIH PAR-09-240 - Genetic and Genomic Analysis of Xenopus (R01)
What is PAR-09-240?
PAR-09-240, titled "Genetic and Genomic Analysis of Xenopus (R01)", was an NIH funding opportunity announcement (FOA) that solicited investigator-initiated research projects focused on strengthening and expanding the use of Xenopus (frog) as a vertebrate model organism for biomedical research, specifically through genetics and genomics.
What was the main purpose of this FOA?
The main goal was to accelerate next-generation Xenopus genetics and genomics by funding R01-level projects that either (1) create high-value genetic/genomic tools and community resources, or (2) apply newer genetic and genomic approaches to uncover genes, pathways, and phenotypes in ways that move the field forward, especially when those approaches had not been widely used in Xenopus before.
What type of grant mechanism did PAR-09-240 use?
This FOA used the NIH Research Project Grant mechanism (R01), which typically supports substantial, multi-year projects that are hypothesis-driven and/or enable broadly useful research capabilities.
Were there companion opportunities with different mechanisms?
Yes. This FOA ran in parallel with two companion announcements that shared the same scientific scope but used different mechanisms: an R03 small grant option (PAR-09-242) and an R21 exploratory/developmental option (PAR-09-241). These provided alternative entry points based on project scale and maturity.
Which NIH Institutes and Centers participated?
The FOA was issued jointly by multiple NIH Institutes and Centers, including NICHD, NHLBI, NIDCD, NIDCR, NIEHS, NIGMS, NIMH, and NINDS, along with the Trans-NIH Xenopus Working Group. This reflected broad NIH interest in Xenopus-based approaches across many biomedical areas.
What scientific areas were emphasized?
The FOA emphasized research that advances detection and characterization of genes and biological pathways and links them to observable phenotypes. Priority areas included developmental biology and organogenesis, and core cell biology topics such as cell division, signaling, and cell migration.
What kinds of projects were considered especially responsive?
Projects were especially responsive if they produced high-priority, broadly useful outputs for the wider Xenopus community, such as shared tools, datasets, or methods that other labs could readily adopt, rather than narrowly tailored, one-off capabilities.
Did the FOA encourage development of community resources?
Yes. A major theme was community benefit and creation of high-value genetic/genomic tools and resources. Applicants were encouraged to expand what the Xenopus community could do at scale and with greater precision by improving genetic resources and genomic analysis capabilities.
Was the FOA focused only on creating tools, or also on applying methods to biological questions?
It supported both. It aimed to fund (1) creation of enabling tools/resources and (2) application of newer genetic/genomic methods to discover gene-function and pathway-phenotype relationships, particularly when these methods were not yet widely used in Xenopus.
Was this an investigator-initiated opportunity?
Yes. It was described as a discretionary, investigator-initiated research grant solicitation, meaning investigators proposed their own project ideas within the scientific scope of the FOA.
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education, nonprofits (501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses, though this was not an SBIR/STTR mechanism), and many governmental and community-based entities.
Were minority-serving institutions and specific organization types included in eligibility?
Yes. The eligibility list explicitly included organization types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, faith-based/community-based organizations, regional organizations, and U.S. territories or possessions.
Could foreign (non-U.S.) organizations apply?
Yes. Non-U.S. entities (foreign organizations) were explicitly listed as eligible, indicating support for strong Xenopus genetics/genomics work wherever it was best positioned to be done, consistent with NIH policies.
Was cost sharing or matching required?
No. The FOA stated there was no cost sharing or matching requirement.
When was PAR-09-240 posted and when did it close?
The FOA was created and posted on July 27, 2009. The original and final closing date was September 30, 2011.
Is this funding opportunity still active?
No. It was a time-limited program announcement. It was archived on October 31, 2011.
What does it mean that the FOA is archived?
Based on the dates provided, archived status indicates the announcement is no longer open for applications and has passed its final closing date.
What were the intended downstream impacts of improving Xenopus genetics and genomics?
The FOA reflected an expectation that strengthened Xenopus genetic and genomic capabilities would have cross-cutting impact across many biomedical domains, including development, physiology, neuroscience, mental health, environmental health, and other disease-relevant research areas.
What do the CFDA numbers indicate about this FOA?
The CFDA numbers associated with the FOA spanned multiple NIH program areas (for example, environmental health, oral diseases, deafness/communication disorders, mental health, cardiovascular diseases, neurological disorders, general biomedical research, and child health and human development), underscoring the broad, multi-institute relevance of the work.
Was this FOA intended to expand the scale and precision of Xenopus research?
Yes. Applicants were encouraged to propose work that enables the community to do genetics/genomics at greater scale and with greater precision, including improving genetic resources, enhancing genomic analysis capabilities, and enabling more informative phenotype discovery and interpretation.
What is the simplest summary of what NIH was trying to fund through PAR-09-240?
R01 projects that either build broadly useful genetic/genomic tools and resources for the Xenopus community, or apply emerging genetic/genomic methods to uncover new gene/pathway/phenotype relationships in development and fundamental cell biology.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 09 240) also looked into and applied for these:
| Funding Opportunity |
|---|
| Genetic and Genomic Analysis of Xenopus (R21) Apply for PAR 09 241 Funding Number: PAR 09 241 Agency: National Institutes of Health Category: Environment Health Income Security and Social Services Funding Amount: $200,000 |
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| Countermeasures Against Chemical Threats (CounterACT) Research Centers of Excellence (U54) Apply for PAR 10 181 Funding Number: PAR 10 181 Agency: National Institutes of Health Category: Environment Health Income Security and Social Services Funding Amount: Case Dependent |
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| Developmental Pharmacology (R03) Apply for PAR 11 058 Funding Number: PAR 11 058 Agency: National Institutes of Health Category: Environment Health Income Security and Social Services Funding Amount: $50,000 |
| Developmental Pharmacology (R21) Apply for PAR 11 059 Funding Number: PAR 11 059 Agency: National Institutes of Health Category: Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Countermeasures Against Chemical Threats (CounterACT) Cooperative Research Projects (U01) Apply for PAR 11 155 Funding Number: PAR 11 155 Agency: National Institutes of Health Category: Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Autism Centers of Excellence Centers (P50) Apply for RFA HD 12 195 Funding Number: RFA HD 12 195 Agency: National Institutes of Health Category: Environment Health Income Security and Social Services Funding Amount: $1,500,000 |
| Autism Centers of Excellence Networks (R01) Apply for RFA HD 12 196 Funding Number: RFA HD 12 196 Agency: National Institutes of Health Category: Environment Health Income Security and Social Services Funding Amount: $2,000,000 |
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