Opportunity Information: Apply for RFA DA 14 009

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "HIV/AIDS and Substance Use Among the Homeless and Unstably Housed (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
  • This funding opportunity was created on Jun 10, 2013 and posted on Jun 10, 2013.
  • Applicants must submit their applications by Nov 15, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
  • Eligible applicants include: City or township governments Special district governments For profit organizations other than small businesses Public and State controlled institutions of higher education Small businesses Independent school districts Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:

The grant opportunity titled "HIV/AIDS and Substance Use Among the Homeless and Unstably Housed (R01)" (Funding Opportunity Number RFA-DA-14-009) is a National Institutes of Health (NIH) research funding announcement aimed at strengthening what is known about how HIV/AIDS and substance use intersect in people who are homeless or living in unstable housing. It was released as part of a broader 2014 NIH expansion focused on HIV/AIDS within the context of drug and alcohol use in populations and settings that have been historically understudied, especially where new prevention and treatment strategies could realistically be developed and put into practice. In that larger package of efforts, NIH also highlighted related calls focused on HIV and substance use among Black/African American women and young men who have sex with men, integrating substance use and HIV services inside HIV care settings, exploratory work on HIV with chronic pain and substance use in older adults, and a coordinating center to harmonize data for Seek, Test, Treat, and Retain approaches. Within that ecosystem, this specific R01 is the one centered on homelessness and housing instability.

At its core, the FOA is asking applicants to propose rigorous research that clarifies the relationships among substance use, HIV risk and infection, HIV disease outcomes, and other co-occurring medical or mental health conditions among homeless and unstably housed individuals. The emphasis is not only on describing the problem, but also on producing evidence that can shape effective prevention and treatment approaches in the real world. NIH signals interest in studies that improve understanding of HIV epidemiology in this population (for example, patterns of infection, transmission risk, and links to specific substances or use behaviors), as well as work that examines how homelessness and unstable housing conditions amplify risk through factors like limited access to care, competing survival needs, stigma, trauma exposure, incarceration histories, and disrupted continuity of treatment.

The announcement encourages a wide range of research topics and designs, but it clearly calls out several priority areas. One major theme is intervention research: developing, implementing, evaluating, and ultimately disseminating HIV prevention interventions that are effective for people experiencing homelessness or unstable housing, particularly where substance use is present. This could include prevention models that fit the realities of shelters, encampments, street outreach, transitional housing, drop-in centers, or other nontraditional settings where conventional clinic-based prevention may not reach people consistently. Another major theme is health services and systems research, especially studies that can improve the quality, effectiveness, and coordination of substance use prevention and treatment services for homeless and unstably housed populations, while also accounting for HIV prevention and HIV treatment needs. In practical terms, NIH is pointing researchers toward questions about service delivery: what models increase uptake of testing, linkage to HIV care, retention in care, and adherence to antiretroviral therapy, while also improving access to evidence-based substance use treatment and harm reduction.

This opportunity uses the R01 mechanism, meaning it is intended for more fully developed research projects rather than small pilot efforts. The activity category is listed under Education/Health, and the CFDA listing is 93.279 (Drug Abuse and Addiction Research Programs). The program does not require cost sharing or matching funds, which can lower barriers for applicants that might not have large pools of unrestricted funding. The estimated total funding level was listed as $4,000,000 for the announcement.

Eligibility is broad and includes many types of organizations that might be positioned to study these issues or partner with frontline service providers. Eligible applicants include state, county, city or township governments; special district governments; public housing authorities and Indian housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; and for-profit organizations (including small businesses and other for-profits that are not small businesses). Tribal eligibility is also included, covering federally recognized tribal governments as well as other tribal organizations. The FOA also explicitly notes eligibility for a range of mission- or population-focused institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs), along with faith-based or community-based organizations, regional organizations, and eligible federal agencies. U.S. territories or possessions may apply as well. Foreign institutions and non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed under NIH policy as described in the announcement.

Timing details show the FOA was posted and created on June 10, 2013, with an original and current closing date of November 15, 2013, and an archive date of December 16, 2013. While those dates indicate this specific announcement is no longer active, the summary still reflects an NIH priority area and a model for what NIH sought to fund at that time: strong, actionable research that explains and addresses the intertwined challenges of HIV/AIDS and substance use in the context of homelessness and unstable housing, with an eye toward interventions and service delivery improvements that can be implemented in the settings where people actually live and seek help.

For reference, the archived NIH guide link associated with the opportunity was listed as http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-14-009.html, and the contact for technical access issues was the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).

FAQs: HIV/AIDS and Substance Use Among the Homeless and Unstably Housed (R01) - RFA-DA-14-009

What is the title of this funding opportunity?

The funding opportunity is titled "HIV/AIDS and Substance Use Among the Homeless and Unstably Housed (R01)."

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number is RFA-DA-14-009.

Which agency is offering this opportunity?

This is a National Institutes of Health (NIH) research funding announcement.

What is the main purpose of this FOA?

The FOA aims to strengthen what is known about how HIV/AIDS and substance use intersect among people who are homeless or living in unstable housing, and to generate evidence that can inform realistic prevention, treatment, and service delivery approaches in real-world settings.

What type of grant mechanism is used?

This opportunity uses the R01 mechanism, which is intended for more fully developed research projects (rather than small pilot efforts).

What research areas does NIH want applicants to address?

The FOA seeks rigorous research that clarifies relationships among substance use, HIV risk and infection, HIV disease outcomes, and co-occurring medical or mental health conditions among homeless and unstably housed individuals.

Is NIH only interested in describing the problem, or also in solutions?

NIH emphasizes not only describing the problem, but also producing evidence that can shape effective prevention and treatment approaches that can realistically be developed and put into practice.

What population is the focus of this FOA?

The focus is on individuals experiencing homelessness or unstable housing, particularly where substance use is present, and how this intersects with HIV/AIDS risk, infection, and outcomes.

What kinds of settings does the FOA consider important for research?

The FOA highlights nontraditional and real-world settings where people experiencing homelessness may be reached, including shelters, encampments, street outreach, transitional housing, drop-in centers, and other settings where clinic-based approaches may not reach people consistently.

What does the FOA say about HIV epidemiology in this population?

NIH signals interest in studies that improve understanding of HIV epidemiology among homeless and unstably housed individuals, including patterns of infection, transmission risk, and links to specific substances or use behaviors.

What factors does NIH highlight that may amplify HIV and substance use risk in the context of homelessness?

The FOA notes that homelessness and unstable housing can amplify risk through factors such as limited access to care, competing survival needs, stigma, trauma exposure, incarceration histories, and disrupted continuity of treatment.

Does the FOA prioritize intervention research?

Yes. A major theme is intervention research: developing, implementing, evaluating, and disseminating HIV prevention interventions that are effective for people experiencing homelessness or unstable housing, particularly when substance use is present.

Does the FOA prioritize health services or systems research?

Yes. Another major theme is health services and systems research focused on improving the quality, effectiveness, and coordination of substance use prevention and treatment services for homeless and unstably housed populations, while also addressing HIV prevention and HIV treatment needs.

What service delivery outcomes does NIH specifically point to?

The FOA points researchers toward service delivery questions and models that can increase uptake of testing, linkage to HIV care, retention in care, and adherence to antiretroviral therapy, while also improving access to evidence-based substance use treatment and harm reduction.

What is the activity category listed for this opportunity?

The activity category is listed under Education/Health.

What CFDA program listing is associated with this FOA?

The CFDA listing is 93.279 (Drug Abuse and Addiction Research Programs).

What was the estimated total funding level for the announcement?

The estimated total funding level listed for the announcement was $4,000,000.

Is cost sharing or matching required?

No. The FOA states that cost sharing or matching funds are not required.

Who is eligible to apply?

Eligibility is broad and includes a wide range of domestic organizations, including:

  • State, county, city, or township governments
  • Special district governments
  • Public housing authorities and Indian housing authorities
  • Independent school districts
  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Nonprofit organizations with or without 501(c)(3) status
  • For-profit organizations (including small businesses and other for-profits that are not small businesses)
  • Federally recognized tribal governments and other tribal organizations
  • U.S. territories or possessions
  • Eligible federal agencies

Are mission- or population-focused institutions explicitly included in eligibility?

Yes. The FOA explicitly notes eligibility for organizations such as HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, AANAPISIs, as well as faith-based or community-based organizations and regional organizations.

Are foreign institutions eligible to apply?

No. Foreign institutions and non-U.S. components of U.S. organizations are not eligible.

Are foreign components allowed under this FOA?

No. The FOA indicates that foreign components are not allowed under NIH policy as described in the announcement.

When was the FOA posted and created?

The FOA was posted and created on June 10, 2013.

What was the application closing date?

The original and current closing date listed is November 15, 2013.

When was the FOA archived?

The archive date listed is December 16, 2013.

Is this funding opportunity still active?

No. Based on the listed closing and archive dates, this specific FOA is no longer active.

How does this FOA relate to other NIH HIV/substance use efforts mentioned in the summary?

This R01 was part of a broader 2014 NIH expansion focused on HIV/AIDS in the context of drug and alcohol use in historically understudied populations and settings. Within that group of efforts, this specific R01 is the one centered on homelessness and housing instability.

Where can the archived NIH guide announcement be found?

The archived NIH guide link associated with the opportunity is: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-14-009.html

Who is listed as the contact for technical access issues?

The contact for technical access issues is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

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