Opportunity Information: Apply for RFA HL 11 010
Apply for RFA HL 11 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pediatric Heart Network Clinical Centers (U10)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research.
- This funding opportunity was created on Jul 19, 2010 and posted on Jul 19, 2010.
- Applicants must submit their applications by Oct 29, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $64,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The Pediatric Heart Network Clinical Centers (U10) opportunity (Funding Opportunity Number RFA-HL-11-010) is a National Institutes of Health, National Heart, Lung, and Blood Institute (NHLBI) funding announcement designed to support the Clinical Centers that make up the Pediatric Heart Network (PHN). The PHN is a cooperative, multicenter clinical research network focused on improving health outcomes and quality of life for children, adolescents, and young adults affected by congenital and acquired heart disease. In practical terms, the network exists to make large, collaborative studies possible by providing a shared infrastructure across multiple hospitals and research sites, allowing investigators to evaluate and compare medical, interventional, and surgical therapies in a coordinated way. A key feature of the PHN is that it is not only a research engine but also a platform for training and workforce development, giving fellows, junior faculty, and nursing staff experience in rigorous multicenter clinical research, while also emphasizing the rapid dissemination of results so evidence can more quickly influence real-world care.
The purpose of the FOA is to invite qualified institutions to apply to serve as PHN Clinical Centers, meaning participating sites that recruit and follow patients, carry out study procedures, and collaborate on network protocols. NHLBI emphasizes that applications should reflect true team-based collaboration, particularly among pediatric cardiologists, pediatric cardiovascular surgeons, and other clinicians and researchers involved in caring for patients with complex cardiovascular conditions. The research scope is broad within pediatric and congenital cardiology: the network aims to evaluate therapeutic and management strategies for children and adults with congenital heart defects, as well as pediatric patients with inflammatory heart disease, cardiomyopathies (heart muscle disease), and arrhythmias. The emphasis on multicenter clinical research signals that the NHLBI is prioritizing studies that require large, diverse patient populations and standardized methods across institutions to produce robust, generalizable findings.
This program uses the U10 cooperative agreement mechanism, which means the award is not a typical investigator-initiated grant with minimal agency involvement. Instead, it is a cooperative arrangement where NHLBI expects substantial scientific and/or programmatic involvement during the conduct of the work. In the PHN context, that typically implies that funded Clinical Centers will operate as part of a coordinated network, adhere to common protocols and governance processes, and work closely with the network leadership and NHLBI to develop, implement, and complete studies. The FOA also notes that there is a separate, companion funding opportunity for the PHN Data Coordinating Center (RFA-HL-11-027), highlighting that the network structure splits responsibilities between clinical sites that conduct the research and a centralized coordinating entity responsible for functions like data management and statistical coordination.
Key administrative details include that the opportunity falls under the Health activity category and the Cardiovascular Diseases Research CFDA program (93.837). The announcement was posted July 19, 2010, with an application deadline of October 29, 2010, and an archive date of November 29, 2010. The estimated total funding amount listed is $64,000,000, and the award ceiling shown is $300,000. No cost sharing or matching is required. While the exact number of awards is not stated in the excerpt, the total funding figure indicates support for a sizable, multi-institution network over the project period.
Eligibility is broad and includes many types of applicant organizations. Eligible applicants listed include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), small businesses, and for-profit organizations other than small businesses. The eligibility section also explicitly includes a range of institution types and communities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. The announcement also indicates that non-U.S. entities (foreign organizations) and eligible federal agencies may apply, depending on the full FOA details.
Overall, this grant opportunity is aimed at building and sustaining the clinical-site backbone of the Pediatric Heart Network so that NHLBI can support high-quality, multicenter studies in congenital and pediatric cardiovascular disease. It is designed for organizations that can demonstrate strong clinical volume and expertise in relevant heart conditions, the ability to recruit and follow participants under shared protocols, and the willingness and capacity to function as part of a tightly coordinated national (and potentially international) research collaborative that generates evidence to improve patient care.
Frequently Asked Questions (FAQs): Pediatric Heart Network Clinical Centers (U10) - RFA-HL-11-010
What is this funding opportunity?
This is the Pediatric Heart Network (PHN) Clinical Centers (U10) funding opportunity from the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI). The Funding Opportunity Number is RFA-HL-11-010. It supports the clinical centers that make up the PHN, a cooperative multicenter clinical research network.
What is the Pediatric Heart Network (PHN)?
The PHN is a cooperative, multicenter clinical research network focused on improving health outcomes and quality of life for children, adolescents, and young adults affected by congenital and acquired heart disease. It exists to make large, collaborative studies possible by providing shared infrastructure across multiple hospitals and research sites.
What is the main purpose of the PHN Clinical Centers funding?
The purpose is to invite qualified institutions to apply to serve as PHN Clinical Centers. These are participating sites that recruit and follow patients, carry out study procedures, and collaborate on network protocols in a coordinated, multicenter way.
What kinds of research does the PHN focus on?
The research scope is broad within pediatric and congenital cardiology. The network aims to evaluate therapeutic and management strategies for:
- Children and adults with congenital heart defects
- Pediatric patients with inflammatory heart disease
- Cardiomyopathies (heart muscle disease)
- Arrhythmias
Why does NHLBI emphasize multicenter clinical research for this program?
The emphasis on multicenter research reflects a priority for studies that require large, diverse patient populations and standardized methods across institutions. This approach helps generate robust, generalizable findings that can be compared across medical, interventional, and surgical therapies.
What is the U10 cooperative agreement mechanism?
The program uses a U10 cooperative agreement, which is not a typical investigator-initiated grant with minimal agency involvement. Under a cooperative agreement, NHLBI expects substantial scientific and/or programmatic involvement during the conduct of the work.
How does a cooperative agreement affect how the Clinical Centers operate?
In the PHN context, a cooperative arrangement generally means funded Clinical Centers will operate as part of a coordinated network, adhere to common protocols and governance processes, and work closely with PHN leadership and NHLBI to develop, implement, and complete studies.
What are the responsibilities of a PHN Clinical Center?
Based on the description provided, Clinical Centers are expected to:
- Recruit and follow patients for PHN studies
- Carry out study procedures at their sites
- Collaborate on network protocols and multicenter projects
- Participate in coordinated network operations under shared protocols and governance
What does NHLBI mean by "team-based collaboration" in this FOA?
NHLBI emphasizes that applications should reflect true team-based collaboration, particularly among pediatric cardiologists, pediatric cardiovascular surgeons, and other clinicians and researchers involved in the care of patients with complex cardiovascular conditions.
Is this program only about conducting research, or are there other goals?
The PHN is described as both a research engine and a platform for training and workforce development. It provides fellows, junior faculty, and nursing staff experience in rigorous multicenter clinical research, and it emphasizes rapid dissemination of results so evidence can more quickly influence real-world care.
Is there a separate funding opportunity for data coordination?
Yes. The FOA notes a separate, companion funding opportunity for the PHN Data Coordinating Center: RFA-HL-11-027. The network structure separates responsibilities between clinical sites (which conduct the research) and a centralized coordinating entity (responsible for functions like data management and statistical coordination).
Which NIH institute is sponsoring this opportunity?
This announcement is from the National Heart, Lung, and Blood Institute (NHLBI), which is part of the National Institutes of Health (NIH).
What is the activity category and CFDA program listed for this opportunity?
The opportunity falls under the Health activity category and the Cardiovascular Diseases Research CFDA program (93.837).
What are the key dates for this opportunity?
- Posted date: July 19, 2010
- Application deadline: October 29, 2010
- Archive date: November 29, 2010
How much funding is available under this announcement?
The estimated total funding amount listed is $64,000,000. The award ceiling shown is $300,000. The excerpt does not specify the exact number of awards, but the total funding figure suggests support for a sizable, multi-institution network over the project period.
Is cost sharing or matching required?
No. The opportunity specifies that no cost sharing or matching is required.
Who is eligible to apply?
Eligibility is described as broad and includes many types of applicant organizations, including:
- Public and private institutions of higher education
- Nonprofit organizations (both 501(c)(3) and non-501(c)(3))
- Small businesses
- For-profit organizations other than small businesses
Are minority-serving institutions and community-based organizations included in eligibility?
Yes. The eligibility section explicitly includes a wide range of institution types and communities, including HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Can foreign (non-U.S.) organizations apply?
The announcement indicates that non-U.S. entities (foreign organizations) may apply, depending on the full FOA details.
Can federal agencies apply?
The announcement indicates that eligible federal agencies may apply, depending on the full FOA details.
What types of institutions are best suited to be PHN Clinical Centers?
The opportunity is aimed at organizations that can demonstrate strong clinical volume and expertise in relevant pediatric and congenital heart conditions, can recruit and follow participants under shared protocols, and have the willingness and capacity to function as part of a tightly coordinated national (and potentially international) research collaborative.
Does the network compare different types of treatments?
Yes. The PHN is described as enabling investigators to evaluate and compare medical, interventional, and surgical therapies in a coordinated way across multiple hospitals and research sites.
What makes this opportunity different from a standard NIH research grant?
This opportunity uses a cooperative agreement (U10), meaning NHLBI expects substantial involvement during the conduct of the work. The Clinical Centers are expected to operate within a coordinated network structure, follow shared protocols, and collaborate through network governance rather than functioning as fully independent projects.
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