PHS 2009 02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR R43/R44) | Apply Online

Opportunity Summary:

PHS 2009-02 (PA-09-080) is an omnibus, "parent" Small Business Innovation Research (SBIR) funding opportunity that brings together multiple federal health and human services agencies under one solicitation. Issued by the National Institutes of Health (NIH) along with the Centers for Disease Control and Prevention (CDC), the Food and Drug Administration (FDA), and the Administration for Children and Families (ACF), the core goal is to encourage eligible US small business concerns to propose early-stage and development-focused research projects that align with the research and development missions of the participating components. In practical terms, it is designed to be a broad entry point for small companies with strong R&D capabilities and technology-driven ideas to pursue innovations that can improve public health, medical care, regulatory science, and social service outcomes, depending on the mission area of the awarding component.

The opportunity uses the SBIR grant mechanisms R43 and R44, which correspond to SBIR Phase I and Phase II awards. Phase I is generally intended to establish feasibility and technical merit, while Phase II supports further development of the technology or product toward commercialization. This announcement explicitly supports Phase I, Phase II, and Fast Track submissions, where Fast Track is meant to speed the transition from Phase I to Phase II through a single, combined application and review approach. It also allows Phase II Competing Renewal applications, but only for NIH applicants, meaning NIH is the only participating agency here that accepts the Phase II renewal option under this FOA. Although the announcement is paired with a parallel solicitation of identical scientific scope for the Small Business Technology Transfer (STTR) program (PA-09-081), it is important that STTR applications are only accepted by NIH; CDC, FDA, and ACF do not participate in STTR. Likewise, SBIR Fast Track and Phase II Competing Renewal submissions are stated to be accepted only by NIH under this solicitation structure.

As a parent SBIR FOA, the topic coverage is intentionally wide. Applicants are directed to submit in response to identified topics in the PHS 2009-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, FDA, and ACF. The breadth of potential areas is reflected in the many CFDA program numbers associated with the solicitation, spanning innovations in applied public health research; FDA research; environmental health; oral health; hazardous substances and Superfund-related research and education; genomics; deafness and communication disorders; complementary and integrative health; mental health; alcohol and substance use research; technological innovations to improve human health; minority health and health disparities; nursing research; broad biomedical research infrastructure; a comprehensive range of cancer research areas (prevention through treatment and control); cardiovascular, lung, blood, and related disorders; arthritis and musculoskeletal diseases; diabetes and digestive and kidney diseases; neurosciences and neurological disorders; allergy, immunology, and transplantation; microbiology and infectious diseases; general biomedical research and training; child health and human development; aging; vision research; and medical library assistance. Taken together, this signals that proposals could range from diagnostics, therapeutics, vaccines, medical devices, digital health tools, lab methods, and public health technologies to interventions and innovations relevant to social services and family support programs, provided they map cleanly to a participating agency's mission and the listed topic areas.

From an administrative standpoint, the opportunity is categorized as discretionary funding and uses a grant as the funding instrument. The eligible applicant pool is limited to small businesses (US small business concerns), consistent with SBIR statutory requirements. The listing indicates there is no cost sharing or matching requirement, which is typical for SBIR grants and lowers the barrier for small firms that may not have non-federal funds available to meet match obligations. The opportunity was posted and created on January 22, 2009, with an original and current closing date of January 7, 2010, and an archive date of February 7, 2010, meaning it is no longer active but serves as a historical reference point for that SBIR cycle. The source data also lists an award ceiling of $100,000, which likely reflects a simplified or system-level field; actual SBIR budgets often depend on agency policy, project scope, and phase, and are typically governed by the detailed FOA instructions and the SBIR program guidelines in effect during that year.

Overall, PA-09-080 functions as a centralized doorway for small businesses to pursue federally funded R&D that has a clear commercialization trajectory and a strong public benefit rationale across health, public health, regulatory science, and human services domains. The key decisions for an applicant would be selecting the appropriate participating agency/component and topic alignment, choosing the correct SBIR mechanism path (Phase I, Phase II, Fast Track, and for NIH only, Phase II Competing Renewal), and ensuring the proposal clearly demonstrates both scientific/technical merit and a credible plan for development and commercialization. For applicants needing the full official instructions, the announcement points to the NIH Grants Guide page for PA-09-080, and provides NIH Office of Extramural Research (OER) webmaster contact details for access or linking issues.

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