Opportunity Information: Apply for RFA CA 14 001
Apply for RFA CA 14 001
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Population based Research Optimizing Screening through Personalized Regimens (PROSPR) Revision to Enhance the Collection of Cervical Cancer Screening Data (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.399 Cancer Control.
- This funding opportunity was created on Nov 4, 2013 and posted on Nov 4, 2013.
- Applicants must submit their applications by Jan 13, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $650,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This grant opportunity, titled "Population based Research Optimizing Screening through Personalized Regimens (PROSPR) Revision to Enhance the Collection of Cervical Cancer Screening Data (U54)" (RFA-CA-14-001), is a National Institutes of Health (NIH) funding announcement that supports a targeted expansion of the existing PROSPR research network. It is structured as a cooperative agreement (U54), meaning NIH expects substantial programmatic involvement and coordination with awardees rather than a hands-off grant mechanism. The core purpose is to strengthen population-based evidence on how cancer screening is delivered in real-world health care settings by adding robust cervical cancer screening data to the PROSPR centralized data resources.
The FOA is not open to the general research community. It specifically invites revision applications only from investigators who already hold active PROSPR Research Center U54 awards that were originally funded under RFA-CA-11-003 and whose current PROSPR work focuses on colorectal cancer screening or breast cancer screening. In other words, it is a limited-eligibility "add-on" to existing PROSPR centers, designed to broaden what those centers already do rather than create new centers. Two important exclusions apply: the single PROSPR center that is already focused on cervical cancer screening is not eligible to apply for this revision, and the PROSPR Statistical Coordinating Center is also not eligible.
The expected focus of the revision is primarily data infrastructure and data capture rather than launching entirely new hypothesis-driven research projects. Applicants are expected to concentrate on collecting multilevel cervical cancer screening process data and submitting those data to the PROSPR central data repository. "Multilevel" in this context signals that the network is trying to capture information at multiple layers of the screening process and health care delivery system, such as patient-level characteristics and screening histories, provider and clinic-level practices, test types and results, follow-up procedures, diagnostic workups, and other process measures that help explain how screening actually happens from start to finish. The goal is to enable analyses that can identify where screening systems work well, where people are lost to follow-up, how different screening strategies perform in practice, and what organizational or patient factors influence outcomes.
Even though the main emphasis is on expanding and standardizing cervical cancer screening data collection, applications are also expected to show that the center has the expertise and operational capacity to participate in collaborative, multicenter research that uses these pooled data. That means applicants should be prepared not only to contribute data but also to work within network-wide governance, common data definitions, shared analytic plans, and cross-site studies that compare screening processes across different populations and health care systems.
From an administrative standpoint, the announcement is categorized as discretionary funding and falls under NIH cancer-related program areas, including Cancer Cause and Prevention Research (CFDA 93.393), Cancer Detection and Diagnosis Research (CFDA 93.394), and Cancer Control (CFDA 93.399). There is no cost sharing or matching requirement. The award ceiling listed is $650,000. The announcement was posted and created on November 4, 2013, with an application due date of January 13, 2014, and an archive date of February 13, 2014, indicating it is a historical opportunity rather than an open, current competition.
Eligibility rules also clarify that non-U.S. (foreign) institutions cannot apply, and non-U.S. components of U.S. organizations are not eligible to apply. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, which typically means a U.S. applicant organization can include certain foreign collaborations or elements if they meet NIH policy definitions and are justified.
Overall, this FOA is best understood as a focused effort to extend the PROSPR network's real-world screening research platform to include cervical cancer screening, primarily by building comparable, high-quality process data across multiple established PROSPR centers and ensuring those centers are prepared to use that shared resource in coordinated, multi-site research.
Frequently Asked Questions (FAQs)
What is the title and FOA number of this grant opportunity?
The opportunity is titled "Population based Research Optimizing Screening through Personalized Regimens (PROSPR) Revision to Enhance the Collection of Cervical Cancer Screening Data (U54)" and is associated with FOA number RFA-CA-14-001.
What type of NIH funding mechanism is this?
This is a cooperative agreement using the U54 mechanism. Under a cooperative agreement, NIH expects substantial programmatic involvement and coordination with the awardees, rather than operating as a fully hands-off grant.
What is the main purpose of this funding announcement?
The purpose is to strengthen population-based evidence on how cancer screening is delivered in real-world health care settings by expanding the PROSPR network's centralized data resources to include robust cervical cancer screening data.
Is this opportunity open to the general research community?
No. This is a limited-eligibility opportunity that invites revision applications only from specific existing PROSPR awardees.
Who is eligible to apply?
Only investigators who already hold active PROSPR Research Center U54 awards originally funded under RFA-CA-11-003 are invited to submit revision applications, and those existing centers must currently focus on colorectal cancer screening or breast cancer screening.
Are any current PROSPR entities explicitly not eligible?
Yes. Two exclusions apply: (1) the single PROSPR center that is already focused on cervical cancer screening is not eligible for this revision, and (2) the PROSPR Statistical Coordinating Center is not eligible.
Is this intended to create new PROSPR centers?
No. This is described as an "add-on" revision to existing PROSPR Research Centers, designed to broaden what current centers already do rather than establish new centers.
What is the expected focus of the revision application?
The revision is expected to focus primarily on data infrastructure and data capture for cervical cancer screening, including collecting and submitting multilevel cervical cancer screening process data to the PROSPR central data repository. It is not primarily intended to launch entirely new hypothesis-driven research projects.
What does "multilevel" cervical cancer screening data mean in this FOA?
"Multilevel" indicates capturing information across multiple layers of the screening process and health care delivery system. Examples referenced include patient-level characteristics and screening histories; provider and clinic-level practices; test types and results; follow-up procedures; diagnostic workups; and other process measures that describe screening from start to finish.
Why is the FOA emphasizing process data and real-world screening delivery?
The intent is to enable analyses that show how screening systems function in practice, including identifying where systems work well, where people are lost to follow-up, how screening strategies perform in real-world settings, and what organizational or patient factors influence outcomes.
What is the role of the PROSPR central data repository in this opportunity?
Applicants are expected to submit the collected cervical cancer screening process data to the PROSPR centralized data resources (the central data repository) to support pooled, network-wide analyses and coordinated studies.
Does the FOA expect centers to do more than just contribute data?
Yes. While expanding and standardizing cervical cancer screening data collection is the main emphasis, the application is also expected to demonstrate expertise and operational capacity to participate in collaborative, multicenter research using pooled PROSPR data.
What kinds of collaborative expectations are described?
Centers should be prepared to work within network-wide governance and coordination, including common data definitions, shared analytic plans, and cross-site studies that compare screening processes across different populations and health care systems.
What NIH program areas or CFDA listings are associated with this announcement?
The announcement is categorized under NIH cancer-related program areas, including Cancer Cause and Prevention Research (CFDA 93.393), Cancer Detection and Diagnosis Research (CFDA 93.394), and Cancer Control (CFDA 93.399).
Is this discretionary funding?
Yes. The announcement is categorized as discretionary funding.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What is the award ceiling listed for this opportunity?
The award ceiling listed is $650,000.
What were the key dates for this funding announcement?
The announcement was posted/created on November 4, 2013. The application due date was January 13, 2014. The archive date was February 13, 2014.
Is this an active/open funding opportunity right now?
Based on the dates provided (including the archive date), this appears to be a historical opportunity rather than an open, current competition.
Can non-U.S. (foreign) institutions apply?
No. The eligibility rules state that non-U.S. (foreign) institutions cannot apply.
Are non-U.S. components of U.S. organizations eligible to apply?
No. Non-U.S. components of U.S. organizations are not eligible to apply.
Are foreign components allowed in any form?
Yes. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. This generally means a U.S. applicant organization may include certain foreign collaborations or elements if they meet NIH policy definitions and are justified.
How does this FOA relate to colorectal and breast cancer screening work in PROSPR?
Eligibility is limited to existing PROSPR Research Centers whose current work focuses on colorectal cancer screening or breast cancer screening, and the revision is intended to broaden those centers' scope by adding cervical cancer screening data collection and submission into the shared PROSPR infrastructure.
What is the overall goal of expanding PROSPR to include cervical cancer screening data?
The overall goal is to build comparable, high-quality cervical cancer screening process data across multiple established PROSPR centers, strengthen the network's real-world screening research platform, and support coordinated multi-site research using the shared data resource.
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