Opportunity Information: Apply for RFA DA 12 007
Apply for RFA DA 12 007
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Remote Monitoring System for Detecting Cocaine Ingestion/Intoxication (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on May 23, 2011 and posted on May 23, 2011.
- Applicants must submit their applications by Aug 18, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) City or township governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Public housing authorities/Indian housing authorities County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The Remote Monitoring System for Detecting Cocaine Ingestion/Intoxication (R01) funding opportunity (RFA-DA-12-007) was a National Institutes of Health (NIH) discretionary grant solicitation aimed at improving how cocaine use is measured during treatment research. The core goal was to support the development and validation of a reliable, remote, real-time monitoring system that clinical trials researchers could use when evaluating treatments for cocaine dependence. The emphasis was on detecting cocaine use "in vivo" (in real-world conditions rather than only in controlled settings) by taking advantage of advances in behavioral sensing and/or biometric sensing, mobile and wireless technologies (including mHealth approaches), and real-time analytic methods.
A central requirement of the announcement was that applicants needed to validate the proposed monitoring system in cocaine-dependent human subjects. Proposals that only validated the technology in non-dependent participants, laboratory simulations, or other populations were explicitly considered non-responsive to the FOA. In other words, the funding was meant to drive systems that work in the exact population relevant to treatment trials, not just systems that perform well in idealized or indirect testing environments.
The FOA envisioned an end-to-end system rather than a single component. A complete solution was expected to include hardware and software elements along with secure data handling and researcher-facing tools. Specifically, systems were expected to provide secure encrypted storage on the device, secure encrypted transmission of data to a database, and secure interfaces that researchers could use to access, aggregate, plot, and display data. The intent behind these requirements was to ensure that the resulting tools would be practical for clinical trial workflows, protect sensitive participant information, and support clinically meaningful interpretation. The output should enable researchers to observe meaningful changes in cocaine consumption patterns over time at the individual participant level, which is crucial for evaluating whether an intervention is actually reducing use.
From an administrative standpoint, this was an R01 grant mechanism, which typically supports discrete, specified, and circumscribed research projects. The opportunity was posted on May 23, 2011, with an original and final application due date of August 18, 2011, and it was archived on September 18, 2011. NIH listed an estimated total funding amount of $1,000,000 for the announcement, with an award ceiling of $300,000. There was no cost-sharing or matching requirement.
Eligibility was broad and included many common U.S. applicant categories: state, county, city/township, and special district governments; public and private institutions of higher education; nonprofits (including 501(c)(3) and other nonprofit structures); for-profit organizations (including small businesses and other for-profit entities); Native American tribal governments and tribal organizations; public housing authorities/Indian housing authorities; and independent school districts. The FOA also clarified additional eligible applicant types such as faith-based and community-based organizations, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), U.S. territories or possessions, and certain regional organizations. Non-U.S. entities (foreign organizations) were allowed, and foreign components of U.S. organizations were permitted as well, reflecting NIH's openness to international collaboration where appropriate.
The opportunity fell under CFDA number 93.279 (Drug Abuse and Addiction Research Programs), aligning it with NIH's broader mission to advance research on substance use disorders. The overall purpose was practical and trial-focused: to move beyond intermittent or self-reported measures of cocaine use and toward continuous or near-real-time detection methods that can strengthen treatment development, improve outcome measurement, and provide more granular, trustworthy data about use patterns in everyday life. For applicants needing the full announcement details, NIH provided a link to the FOA text and contact information for technical access issues via the NIH Office of Extramural Research (OER) webmaster.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This was an NIH discretionary funding opportunity titled "Remote Monitoring System for Detecting Cocaine Ingestion/Intoxication (R01)" (RFA-DA-12-007). It supported research to develop and validate a remote, real-time monitoring system to detect cocaine ingestion/intoxication for use in treatment research and clinical trials.
What was the main goal of the FOA?
The core goal was to improve how cocaine use is measured during treatment research by supporting development and validation of a reliable system that can detect cocaine use in vivo (in real-world conditions). The intent was to give clinical trials researchers a practical tool for evaluating treatments for cocaine dependence using more continuous and trustworthy measures than intermittent testing or self-report.
What does "in vivo" detection mean in this announcement?
In this FOA, "in vivo" refers to detecting cocaine ingestion/intoxication in real-world conditions rather than only in controlled laboratory environments. The emphasis was on capturing use patterns as they occur in everyday life during treatment research.
What types of technologies did the FOA encourage?
The announcement emphasized approaches leveraging advances in behavioral sensing and/or biometric sensing, mobile and wireless technologies (including mHealth approaches), and real-time analytic methods.
Was validation in cocaine-dependent human subjects required?
Yes. A central requirement was validation of the proposed monitoring system in cocaine-dependent human subjects.
Would a study be considered non-responsive if validation was done only in other populations?
Yes. Proposals that only validated the technology in non-dependent participants, laboratory simulations, or other populations were explicitly described as non-responsive to the FOA.
Was the FOA looking for a single device/component or a complete solution?
The FOA envisioned an end-to-end system rather than a single component. A complete solution was expected to include hardware and software elements, secure data handling, and researcher-facing tools to support clinical trial workflows.
What data security features were expected for the monitoring system?
The FOA expected secure encrypted storage on the device and secure encrypted transmission of data to a database.
What researcher-facing capabilities were expected?
The system was expected to provide secure interfaces that researchers could use to access, aggregate, plot, and display data.
What kind of outputs was the system expected to support for clinical trials?
The output was intended to enable researchers to observe meaningful changes in cocaine consumption patterns over time at the individual participant level, supporting evaluation of whether an intervention reduces use.
What grant mechanism was used for this opportunity?
This opportunity used the NIH R01 grant mechanism, which typically supports discrete, specified, and circumscribed research projects.
When was the opportunity posted and when were applications due?
The FOA was posted on May 23, 2011. The original and final application due date was August 18, 2011.
Is this funding opportunity still active?
No. The FOA was archived on September 18, 2011.
How much total funding did NIH estimate for this announcement?
NIH listed an estimated total funding amount of $1,000,000 for the announcement.
Was there an award ceiling?
Yes. The award ceiling listed for the announcement was $300,000.
Was cost-sharing or matching required?
No. The FOA stated there was no cost-sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad and included state, county, city/township, and special district governments; public and private institutions of higher education; nonprofits (including 501(c)(3) and other nonprofit structures); for-profit organizations (including small businesses and other for-profit entities); Native American tribal governments and tribal organizations; public housing authorities/Indian housing authorities; and independent school districts.
Were specific institution types explicitly called out as eligible?
Yes. The FOA clarified additional eligible applicant types such as faith-based and community-based organizations, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), U.S. territories or possessions, and certain regional organizations.
Were non-U.S. organizations allowed to apply?
Yes. Non-U.S. entities (foreign organizations) were allowed, and foreign components of U.S. organizations were also permitted.
What CFDA number was associated with this opportunity?
The FOA fell under CFDA number 93.279, labeled "Drug Abuse and Addiction Research Programs."
What problem was NIH trying to solve with this funding opportunity?
The purpose was to move beyond intermittent or self-reported measures of cocaine use and toward continuous or near-real-time detection methods that can strengthen treatment development and improve outcome measurement in cocaine dependence treatment trials.
What was the practical intended use of the developed system?
The system was intended to be usable by clinical trials researchers when evaluating treatments for cocaine dependence, with secure data capture and analysis capabilities aligned with real clinical trial workflows.
Where could applicants find the full FOA details and who was listed for technical access help?
NIH provided a link to the FOA text for full details. For technical access issues, the NIH Office of Extramural Research (OER) webmaster was listed as a contact.
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