Opportunity Information: Apply for RFA HG 11 014
Apply for RFA HG 11 014
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Technology Development for High Throughput Functional Genomics (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on May 23, 2011 and posted on May 23, 2011.
- Applicants must submit their applications by Aug 2, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Private institutions of higher education Public and State controlled institutions of higher education County governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Small businesses Special district governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The Technology Development for High Throughput Functional Genomics (R21) opportunity (Funding Opportunity Number RFA-HG-11-014) is a discretionary NIH grant run by the National Human Genome Research Institute (NHGRI) to spur the creation of new or significantly improved technologies for functional genomics in eukaryotic genomes. The central aim is to make it faster, more comprehensive, and more scalable to identify, validate, and characterize sequence-based functional elements, meaning DNA-encoded features that do something biologically meaningful, such as regulatory regions, transcription factor binding sites, chromatin-associated elements, and other functional sequences that influence how genomes operate. The program is positioned as a technology development effort tied to the broader goals of ENCODE, continuing a push that began in 2003 to build tools that can systematically map and test functional parts of the genome rather than studying them one by one.
This announcement uses the NIH R21 Exploratory/Developmental Research mechanism, which is designed for early-stage, higher-risk ideas where the emphasis is on innovation and proof of concept. In practical terms, the R21 is meant to help teams demonstrate feasibility, generate preliminary data, and test bold technical approaches that could later mature into larger, more definitive projects. The expectation is not that applicants will already have a fully mature platform, but that they can present a convincing development plan and show that the proposed technology has a plausible path to working and making an impact on high-throughput functional genomics.
NHGRI framed this R21 as part of a coordinated set of funding opportunities with the same scientific scope but different grant mechanisms. Applicants whose projects are better suited to a full-scale research project could look to the parallel R01 version (RFA-HG-11-013), while small businesses interested in developing products or commercializable tools could consider the SBIR pathway (RFA-HG-11-015 under the R43/R44 mechanism). Together, these FOAs were structured to support a pipeline of technology innovation, ranging from exploratory concepts (R21), to more advanced academic projects (R01), to small business development and translation (R43/R44).
Key administrative details are straightforward. The activity category is Health (CFDA 93.172, Human Genome Research), with an estimated total funding level of $5,000,000. The opportunity was posted and created on May 23, 2011, with an original and current closing date of August 2, 2011, and an archive date of September 2, 2011. There is no cost sharing or matching requirement, which means applicants are not required to commit non-federal funds as a condition of the award.
Eligibility is broad and includes many types of organizations. Eligible applicants span public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and a wide range of governmental entities such as state, county, city/township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Tribal eligibility is also extensive, covering federally recognized tribal governments as well as tribal organizations that are not federally recognized, and tribally controlled colleges and universities. The FOA also explicitly includes a variety of institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, and U.S. territories or possessions. Importantly, non-U.S. entities (foreign organizations) are allowed, and foreign components of U.S. organizations are permitted, indicating NHGRI was open to international participation where it strengthens the technology development goals.
For applicants and interested parties looking for the full announcement details, the FOA points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-11-014.html. For access or technical issues related to the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: Technology Development for High Throughput Functional Genomics (R21) - RFA-HG-11-014
What is the name of this funding opportunity?
The opportunity is called Technology Development for High Throughput Functional Genomics (R21). The Funding Opportunity Number is RFA-HG-11-014.
Which federal agency and institute are running this opportunity?
This is an NIH grant opportunity run by the National Human Genome Research Institute (NHGRI).
What is the main purpose of this R21?
The central purpose is to spur the creation of new or significantly improved technologies for functional genomics in eukaryotic genomes, with an emphasis on making functional element discovery and characterization faster, more comprehensive, and more scalable.
What kinds of genomic features does the FOA consider "sequence-based functional elements"?
The FOA describes DNA-encoded functional elements as biologically meaningful features such as regulatory regions, transcription factor binding sites, chromatin-associated elements, and other functional sequences that influence how genomes operate.
How does this opportunity relate to ENCODE?
The program is positioned as a technology development effort tied to ENCODE's broader goals, continuing a push that began in 2003 to build tools that can systematically map and test functional parts of the genome rather than studying them one by one.
What grant mechanism is used, and what does it imply for applicants?
This announcement uses the NIH R21 Exploratory/Developmental Research mechanism. It is intended for early-stage, higher-risk ideas where innovation and proof of concept are emphasized, and where teams aim to demonstrate feasibility and generate preliminary data.
Is the R21 intended for fully mature platforms?
No. The expectation is not that applicants already have a fully mature platform. Applicants are expected to present a convincing development plan and a plausible path to a working technology that can impact high-throughput functional genomics.
What stage of research is this R21 designed to support?
It is designed to support exploratory technology development, feasibility demonstration, and proof-of-concept work that could later mature into larger, more definitive projects.
Are there related funding opportunities for similar work?
Yes. NHGRI described this R21 as part of a coordinated set of FOAs with the same scientific scope but different mechanisms: an R01 version (RFA-HG-11-013) for full-scale research projects, and an SBIR pathway (RFA-HG-11-015) under the R43/R44 mechanism for small businesses focused on products or commercializable tools.
How are the R21, R01, and SBIR FOAs positioned together?
Together they were structured to support a pipeline of technology innovation, ranging from exploratory concepts (R21), to more advanced academic projects (R01), to small business development and translation (R43/R44).
What is the activity category and CFDA number for this opportunity?
The activity category is Health. The CFDA is 93.172 (Human Genome Research).
How much total funding was estimated for this opportunity?
The estimated total funding level is $5,000,000.
When was the opportunity posted, and what were the key dates?
The opportunity was posted and created on May 23, 2011. The original and current closing date was August 2, 2011. The archive date was September 2, 2011.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, meaning applicants were not required to commit non-federal funds as a condition of the award.
What types of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); and many governmental entities such as state, county, and city/township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes federally recognized tribal governments, tribal organizations that are not federally recognized, and tribally controlled colleges and universities.
Does the FOA encourage or allow applications from certain institution types like HBCUs or Hispanic-serving institutions?
Yes. The FOA explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Are U.S. territories or possessions included in eligible applicants?
Yes. The FOA explicitly includes U.S. territories or possessions.
Are non-U.S. (foreign) organizations allowed to apply?
Yes. Non-U.S. entities (foreign organizations) are allowed.
Are foreign components of U.S. organizations permitted?
Yes. The FOA states that foreign components of U.S. organizations are permitted, indicating openness to international participation where it strengthens the technology development goals.
Where can applicants find the full official announcement text?
The FOA points to the NIH Grants Guide page: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-11-014.html
Who is the listed contact for access or technical issues with the announcement?
For access or technical issues related to the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall scientific focus area of the work being funded?
The overall focus is functional genomics technology development in eukaryotic genomes, specifically to enable high-throughput identification, validation, and characterization of functional DNA elements.
What is the practical outcome NHGRI is trying to enable with this FOA?
The FOA aims to accelerate and scale the ability to systematically map and test functional genomic elements, moving away from studying genome function one element at a time.
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