Opportunity Information: Apply for PA 15 027
Apply for PA 15 027
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Research on Eosinophil Associated Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jan 12, 2015 and posted on Oct 31, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education For profit organizations other than small businesses Special district governments Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education City or township governments County governments Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This NIH grant opportunity, titled Research on Eosinophil Associated Disorders (R01) (Funding Opportunity Number PA-15-027), supports investigator-initiated research projects that focus on eosinophil-associated diseases and the underlying biology of eosinophil leukocytes. The central goal is to deepen understanding of disease pathophysiology by clarifying how eosinophils contribute to inflammation, tissue injury, immune regulation, and other disease-driving processes. Applications are expected to emphasize cellular and molecular mechanisms, meaning projects that move beyond description and aim to explain how and why eosinophils, their mediators, and their interactions with other cells lead to specific disease features and outcomes. The FOA is positioned to encourage work that can ultimately inform better diagnostics, prevention strategies, and therapeutic approaches for conditions where eosinophils play a major role.
The award mechanism is the NIH R01, which is the standard research project grant used to fund well-developed, hypothesis-driven or mechanistically oriented studies. The announcement sits within NIH’s discretionary grant programs and aligns with several NIH activity areas reflected by the listed CFDA numbers, including Arthritis, Musculoskeletal and Skin Diseases Research (93.846), Diabetes, Digestive, and Kidney Diseases Extramural Research (93.847), and Allergy and Infectious Diseases Research / Microbiology and Infectious Diseases Research (93.855 and 93.856). Taken together, that framing signals broad scientific relevance across allergic disease, immune-mediated conditions, gastrointestinal disorders, skin and connective tissue disease, and infectious disease contexts where eosinophils may be important contributors or modifiers.
A wide range of applicant organizations are eligible. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than higher education institutions), for-profit organizations (other than small businesses), small businesses, and multiple levels of government entities such as state, county, city or township governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities. The eligibility language also explicitly includes tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments). In addition, the FOA highlights a broad set of other eligible applicant types, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.
Notably, the opportunity allows international participation. Non-U.S. entities (foreign organizations) and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations may participate, and foreign components (as defined by the NIH Grants Policy Statement) are allowed. This flexibility encourages research teams to leverage unique patient populations, specialized expertise, and distinctive scientific resources wherever they are located, which can be especially important for less common eosinophil-associated disorders or for studies requiring particular clinical cohorts, specimens, or research infrastructure.
No cost sharing or matching is required, which reduces barriers to entry and allows applicants to focus on building the strongest possible scientific and technical case for the proposed work. The opportunity was posted on October 31, 2014, created on January 12, 2015, and ultimately archived on February 7, 2018, with the listed original closing date of May 7, 2018 and a current closing date shown as January 7, 2018. For full details, applicants were directed to the NIH funding announcement page at http://grants.nih.gov/grants/guide/pa-files/PA-15-027.html. Administrative help for access or linking issues is routed through the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
In practical terms, the FOA is meant for research that explains eosinophil involvement in disease at a mechanistic level, including how eosinophils develop, traffic into tissues, become activated, interact with other immune or structural cells, and release mediators that shape inflammation and tissue remodeling. It also invites work that dissects signaling pathways, transcriptional and epigenetic programs, receptor-ligand interactions, and other molecular events that determine eosinophil behavior and downstream effects in eosinophil-associated disorders. While the specific scientific scope and examples are laid out in the full announcement, the overarching emphasis is clear: rigorous, mechanistic studies that reveal how eosinophils contribute to disease processes and that help clarify their roles across a spectrum of eosinophil-linked conditions.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled Research on Eosinophil Associated Disorders (R01) and the Funding Opportunity Number (FOA number) is PA-15-027.
What is the main purpose of this funding opportunity?
The central goal is to support investigator-initiated research that deepens understanding of eosinophil-associated diseases and the underlying biology of eosinophil leukocytes. The FOA emphasizes clarifying how eosinophils contribute to disease pathophysiology, including their roles in inflammation, tissue injury, immune regulation, and other disease-driving processes, with the longer-term intent of informing improved diagnostics, prevention strategies, and therapeutic approaches.
What type of NIH award mechanism does this opportunity use?
This opportunity uses the NIH R01 mechanism, which is the standard NIH research project grant intended to support well-developed, hypothesis-driven or mechanistically oriented studies.
What kinds of research projects are expected to be a strong fit?
Projects are expected to emphasize cellular and molecular mechanisms, meaning studies that go beyond describing observations and instead explain how and why eosinophils, their mediators, and their interactions with other cells lead to specific disease features and outcomes.
Does the FOA focus on descriptive studies or mechanistic studies?
The stated emphasis is on rigorous, mechanistic studies. The FOA is framed around research that clarifies causal and functional roles for eosinophils in disease processes rather than purely descriptive work.
What aspects of eosinophil biology does the FOA highlight as relevant?
The FOA highlights mechanistic research on topics such as how eosinophils:
- Develop and differentiate
- Traffic into tissues
- Become activated
- Interact with other immune cells or structural cells
- Release mediators that shape inflammation and tissue remodeling
- Engage in signaling pathways, transcriptional and epigenetic programs, and receptor-ligand interactions that determine eosinophil behavior and downstream effects
What disease areas or NIH program areas does this FOA align with?
The FOA is positioned within NIH discretionary grant programs and aligns with multiple NIH-related activity areas reflected by the listed CFDA numbers, including:
- 93.846 Arthritis, Musculoskeletal and Skin Diseases Research
- 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research
- 93.855 Allergy and Infectious Diseases Research
- 93.856 Microbiology and Infectious Diseases Research
Collectively, this framing signals broad relevance across allergic disease, immune-mediated conditions, gastrointestinal disorders, skin and connective tissue disease, and infectious disease contexts where eosinophils may be important contributors or modifiers.
Who is eligible to apply?
A wide range of applicant organizations are eligible, including:
- Public and private institutions of higher education
- Nonprofit organizations (with or without 501(c)(3) status, other than higher education institutions)
- For-profit organizations (other than small businesses)
- Small businesses
- State governments
- County governments
- City or township governments
- Independent school districts
- Special district governments
- Public housing authorities / Indian housing authorities
- Tribal governments (federally recognized)
- Native American tribal organizations (other than federally recognized tribal governments)
Are minority-serving institutions and community-based organizations included in eligibility?
Yes. The eligibility language explicitly includes multiple categories such as:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
- Eligible federal agencies
Are international (non-U.S.) organizations allowed to apply?
Yes. The opportunity allows international participation, including:
- Non-U.S. entities (foreign organizations) and foreign institutions as eligible applicants
- Non-U.S. components of U.S. organizations as allowable participants
- Foreign components (as defined by the NIH Grants Policy Statement) as allowable
Why does the FOA allow foreign components or foreign applicants?
The FOA notes that this flexibility can help teams leverage unique patient populations, specialized expertise, and distinctive scientific resources located outside the U.S., which may be especially relevant for less common eosinophil-associated disorders or studies needing specific clinical cohorts, specimens, or research infrastructure.
Is cost sharing or matching required?
No. The opportunity states that no cost sharing or matching is required.
When was this funding opportunity posted and when was it archived?
The opportunity was posted on October 31, 2014, created on January 12, 2015, and archived on February 7, 2018.
What are the closing dates listed for this FOA?
The information provided lists an original closing date of May 7, 2018 and a current closing date shown as January 7, 2018.
Where can applicants find the full FOA details?
Full details were provided through the NIH funding announcement page at: http://grants.nih.gov/grants/guide/pa-files/PA-15-027.html
Who should be contacted for administrative help related to access or linking issues?
Administrative help for access or linking issues is routed through the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall scientific emphasis of the FOA in practical terms?
In practical terms, the FOA is meant to support research that explains eosinophil involvement in disease at a mechanistic level. That includes dissecting molecular and cellular events that govern eosinophil behavior and clarifying how those behaviors translate into disease processes and clinical outcomes across a spectrum of eosinophil-linked conditions.
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