Opportunity Information: Apply for PA 06 405
Apply for PA 06 405
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Studies of Energy Balance and Cancer in Humans (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.399 Cancer Control.
- This funding opportunity was created on Dec 5, 2008 and posted on May 9, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) State governments Independent school districts County governments Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments City or township governments For profit organizations other than small businesses.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity PA-06-405, titled "Studies of Energy Balance and Cancer in Humans (R21)," supports exploratory and developmental research that looks closely at how energy balance relates to cancer. In this context, "energy balance" generally refers to the interplay among factors like diet, physical activity, body weight and body composition, metabolism, and related behaviors or physiological processes that determine energy intake and expenditure. The central goal of this opportunity is to improve understanding of which energy balance-related factors matter most and what biological or behavioral mechanisms connect those factors to cancer risk (whether someone develops cancer), prognosis (how cancer progresses and outcomes after diagnosis), and quality of life (how patients feel and function during and after treatment).
This announcement is specifically geared toward human-focused research and encourages projects that can quickly test ideas, generate preliminary evidence, or open up new directions that could later be expanded into larger studies. It allows a broad range of study approaches, including new analyses of existing datasets (for example, reanalyzing cohort, clinical, or population datasets to explore new hypotheses about obesity, exercise, diet patterns, or metabolic markers) as well as projects that add new data collection or collect additional biological specimens within ongoing investigations. The intent is to leverage existing resources when possible, while still leaving room for targeted, practical additions that make it possible to examine mechanisms, identify meaningful associations, or refine measurement strategies related to energy balance and cancer outcomes.
The award mechanism is the NIH Exploratory/Developmental Grant (R21), which is designed for early-stage or high-potential concepts that may not yet have extensive preliminary data. Consistent with the R21 structure, the project period is capped at 2 years. The budget limits are also clearly defined: applicants may request up to $275,000 in direct costs total across the 2-year period, with a maximum of $200,000 in direct costs in any single year. While the scientific scope is fixed around energy balance and cancer in humans, the FOA notes that the exact size and structure of each award can vary depending on the work proposed, and that actual awards depend on available funds and the quality and merit of applications received.
NIH anticipated making about three awards under this R21 announcement, though final numbers depend on appropriations, the number of strong submissions, and the requested budgets. The FOA also runs in parallel with a separate but scientifically identical announcement (PA-06-404) that uses the R01 mechanism, which is generally intended for larger, more mature research projects. In other words, applicants with smaller, more exploratory aims or short, focused pilot-style projects would typically align with this R21, while more extensive, fully powered projects might fit the companion R01 announcement.
Eligibility is broad. A wide variety of organization types may apply, including public or private institutions such as universities, colleges, hospitals, and laboratories; nonprofit and for-profit organizations; units of state and local government; eligible federal agencies; and domestic or foreign institutions. Faith-based and community-based organizations are explicitly eligible, and the announcement also includes eligibility for Indian/Native American tribal governments (both federally recognized and other than federally recognized) and tribally designated organizations. There is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds to receive an award.
The opportunity is open to any qualified Project Director/Principal Investigator (PD/PI) with the appropriate expertise, institutional support, and resources to carry out the work. NIH also reiterates its standard encouragement for applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities. Applicants may submit more than one application as long as each submission is scientifically distinct, which can be helpful for teams with multiple ideas that address different mechanisms, populations, or methods within the broader energy balance and cancer theme.
Administratively, this is a discretionary grant opportunity within NIH's health and research mission areas, linked to CFDA numbers 93.393 (Cancer Cause and Prevention Research) and 93.399 (Cancer Control). The original posting date was May 9, 2006, with multiple receipt dates (meaning there were several submission deadlines rather than a single closing date), and the program was later archived (archive date June 1, 2009). For full details, NIH provided an official announcement page and contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
Frequently Asked Questions (FAQ)
What is the NIH funding opportunity PA-06-405?
PA-06-405 is a National Institutes of Health (NIH) funding opportunity titled "Studies of Energy Balance and Cancer in Humans (R21)." It supports exploratory and developmental human-focused research on how energy balance relates to cancer, including cancer risk, prognosis, and quality of life.
What does "energy balance" mean in this announcement?
In this FOA, "energy balance" generally refers to the interplay among diet, physical activity, body weight and body composition, metabolism, and related behaviors or physiological processes that determine energy intake and expenditure.
What is the main goal of this funding opportunity?
The central goal is to improve understanding of which energy balance-related factors matter most and to clarify the biological or behavioral mechanisms that connect those factors to cancer risk, cancer prognosis, and quality of life during and after cancer treatment.
Is this opportunity limited to human research?
Yes. The announcement is specifically geared toward human-focused research.
What types of research projects does PA-06-405 encourage?
The FOA encourages projects that can quickly test ideas, generate preliminary evidence, or open new directions that could later be expanded into larger studies. It supports exploratory and developmental work consistent with the R21 mechanism.
Can I use existing datasets for this R21?
Yes. The FOA explicitly allows new analyses of existing datasets, such as reanalyzing cohort, clinical, or population datasets to explore new hypotheses related to obesity, exercise, diet patterns, or metabolic markers and their relationships to cancer outcomes.
Does the FOA allow collection of new data or biological specimens?
Yes. In addition to reanalysis of existing data, the FOA allows projects that add new data collection or collect additional biological specimens within ongoing investigations.
What is the intended approach to using resources in this program?
The intent is to leverage existing resources when possible, while still allowing targeted, practical additions that enable mechanism-focused questions, identification of meaningful associations, or refinement of measurement strategies related to energy balance and cancer outcomes.
What grant mechanism is used for PA-06-405?
This opportunity uses the NIH Exploratory/Developmental Grant mechanism (R21), which is designed for early-stage or high-potential concepts that may not yet have extensive preliminary data.
What is the maximum project period for an award?
The project period is capped at 2 years, consistent with the R21 mechanism.
What are the budget limits for this opportunity?
Applicants may request up to $275,000 in direct costs total across the 2-year period, with a maximum of $200,000 in direct costs in any single year.
Are award sizes fixed, or can they vary?
While the scientific scope is focused on energy balance and cancer in humans and the budget caps apply, the FOA notes that the exact size and structure of each award can vary depending on the work proposed. Actual awards depend on available funds and the quality and merit of applications received.
How many awards did NIH anticipate making under this announcement?
NIH anticipated making about three awards under this R21 announcement, though final numbers depend on appropriations, the number of strong submissions, and the requested budgets.
Is there a related NIH announcement for larger projects?
Yes. The FOA runs in parallel with a separate but scientifically identical announcement (PA-06-404) that uses the R01 mechanism, which is typically intended for larger, more mature research projects.
How do I decide between the R21 (PA-06-405) and the companion R01 (PA-06-404)?
This R21 is generally a better fit for smaller, more exploratory aims or short, focused pilot-style projects. More extensive, fully powered projects may be better aligned with the companion R01 announcement.
What types of organizations are eligible to apply?
Eligibility is broad and includes public or private institutions such as universities, colleges, hospitals, and laboratories; nonprofit and for-profit organizations; units of state and local government; eligible federal agencies; and domestic or foreign institutions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly eligible under this opportunity.
Are tribal governments and tribally designated organizations eligible?
Yes. The announcement includes eligibility for Indian/Native American tribal governments (both federally recognized and other than federally recognized) and tribally designated organizations.
Are foreign institutions eligible to apply?
Yes. The eligibility statement includes domestic or foreign institutions.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement for this opportunity.
Who can serve as the Project Director/Principal Investigator (PD/PI)?
The opportunity is open to any qualified PD/PI with the appropriate expertise, institutional support, and resources to carry out the proposed work.
Does NIH encourage applications from underrepresented groups?
Yes. NIH reiterates its standard encouragement for applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities.
Can an applicant submit more than one application?
Yes. Applicants may submit more than one application as long as each submission is scientifically distinct.
What does "scientifically distinct" mean in the context of multiple applications?
The FOA states that multiple applications are allowed as long as each addresses a different scientific question or approach (for example, different mechanisms, populations, or methods) within the broader theme of energy balance and cancer.
What CFDA numbers are associated with this funding opportunity?
This opportunity is linked to CFDA 93.393 (Cancer Cause and Prevention Research) and 93.399 (Cancer Control).
When was PA-06-405 posted, and what is its current status?
The original posting date was May 9, 2006. The program later became archived, with an archive date of June 1, 2009.
Were there multiple deadlines for submission?
Yes. The FOA had multiple receipt dates, meaning it offered several submission deadlines rather than a single closing date.
Where can applicants go for official access or help with linking issues?
NIH provided an official announcement page and contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
What NIH mission areas does this opportunity fall under?
It is described as a discretionary grant opportunity within NIH's health and research mission areas, focused on energy balance and cancer in humans.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 06 405) also looked into and applied for these:
| Funding Opportunity |
|---|
| Phased Innovation Research in Cancer Prognosis and Prediction (R21/R33) Apply for PA 06 434 Funding Number: PA 06 434 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Phase II Developmental Research in Cancer Prognosis and Prediction (R33) Apply for PA 06 435 Funding Number: PA 06 435 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| The Development of Frontal Cortex and Limbic System and their roles in Drug Abuse or Mental Health (R21) Apply for PA 06 445 Funding Number: PA 06 445 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Drug Abuse Dissertation Research Epidemiology, Prevention, Treatment, Services, and Women and Sex/Gender Differences (R36) Apply for PAR 06 476 Funding Number: PAR 06 476 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Behavioral and Integrative Treatment Development Program (R21) Apply for PA 06 487 Funding Number: PA 06 487 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Behavioral and Integrative Treatment Development Program (R03) Apply for PA 06 488 Funding Number: PA 06 488 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R21) Apply for PA 06 496 Funding Number: PA 06 496 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R03) Apply for PA 06 497 Funding Number: PA 06 497 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis(R21) Apply for PA 06 499 Funding Number: PA 06 499 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Pathophysiology of Bisphosphonates associated Osteonecrosis of the Jaw (R03) Apply for PA 06 502 Funding Number: PA 06 502 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Pathophysiology of Bisphosphonates associated Osteonecrosis of the Jaw (R21) Apply for PA 06 501 Funding Number: PA 06 501 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| National Cancer Institute (NCI) Cancer Education and Career Development Program (R25) Apply for PAR 06 511 Funding Number: PAR 06 511 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R21) Apply for PA 06 461 Funding Number: PA 06 461 Agency: National Institutes of Health Category: Education Health Funding Amount: $250,000 |
| Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R33) Apply for PA 06 462 Funding Number: PA 06 462 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (Phased Innovation Award R21/R33) Apply for PA 06 463 Funding Number: PA 06 463 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R03) Apply for PAR 06 520 Funding Number: PAR 06 520 Agency: National Institutes of Health Category: Education Health Funding Amount: $250,000 |
| Dissemination and Implementation Research in Health (R21) Apply for PAR 06 521 Funding Number: PAR 06 521 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Translational Research for the Prevention and Control of Diabetes and Obesity (R18) Apply for PAR 06 532 Funding Number: PAR 06 532 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Behavioral Science Track Award for Rapid Transition (B/START) (R03) Apply for PAR 06 541 Funding Number: PAR 06 541 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Development, Application, and Evaluation of Prediction Models for Cancer Risk and Prognosis (R21) Apply for PA 07 022 Funding Number: PA 07 022 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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