Opportunity Information: Apply for RFA DK 12 002
Apply for RFA DK 12 002
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "The Collaborative Islet Transplantation Registry (UC4)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Mar 2, 2012 and posted on Mar 2, 2012.
- Applicants must submit their applications by May 16, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $530,000.00 in funding.
- Eligible applicants include: Independent school districts Special district governments Private institutions of higher education Public housing authorities/Indian housing authorities City or township governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) State governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education County governments Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The funding opportunity RFA-DK-12-002, titled "The Collaborative Islet Transplantation Registry (UC4)," is a National Institutes of Health (NIH) cooperative agreement intended to continue support for the Collaborative Islet Transplantation Registry (CITR). CITR has operated since 2001 as a North America-wide registry designed to capture and document essentially all clinical islet transplantation activity, building a comprehensive picture of how this therapy is being used and how well it works in real-world clinical settings. The overall purpose is to maintain an ongoing, centralized resource that systematically collects, curates, and analyzes data on islet transplantation, then turns those data into information the research community and CITR investigators can use to understand outcomes, compare practices, and improve future patient care for people with type 1 diabetes who may be candidates for islet transplantation.
The core work supported under this announcement centers on robust data collection and long-term data infrastructure. Applicants are expected to develop, operate, and maintain sophisticated databases that can securely store detailed clinical and procedural information related to islet transplantation. Just as importantly, the registry is meant to be usable, not just archival: the database environment should support analysis and reporting that enables investigators to publish findings, present results, and answer evolving research questions as the field changes. In practical terms, the opportunity emphasizes both the operational side (capturing high-quality, standardized data across sites over time) and the scientific utility side (making the dataset analyzable, reliable, and accessible for legitimate research and dissemination).
A major required product of the registry is an annual report that summarizes islet transplantation outcomes and describes trends over time. This reporting function is meant to provide a consistent, year-over-year view of how the therapy is performing across the region, which can include changes in patient selection, procedural approaches, immunosuppression strategies, short- and long-term outcomes, and other measurable indicators of success or complications. By continually analyzing accumulated data, CITR is positioned to identify risk factors and determinants of success, helping clinicians and researchers understand what predicts better or worse outcomes. The public health and scientific value is that these insights can guide improvements in clinical protocols, inform future trials, and support evidence-based decision-making in a therapy area where experience is distributed across many centers and practices can evolve quickly.
From an administrative and funding standpoint, this is a discretionary opportunity using a cooperative agreement mechanism (UC4), which typically signals substantial NIH involvement during the project period compared with a standard grant. The announcement lists the activity category under Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847). The estimated total funding is $4,000,000, with an award ceiling of $530,000, and there is no cost sharing or matching requirement. The opportunity was posted on March 2, 2012, with an original and current closing date of May 16, 2012, and an archive date of June 16, 2012, indicating it is a past funding opportunity but still useful as a reference for the scope and expectations of the CITR program.
Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include state, county, city or township governments, special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (excluding certain higher education constraints as specified), for-profit organizations (including small businesses and other for-profits), public housing authorities/Indian housing authorities, and a range of tribal entities and regional organizations. The announcement also explicitly includes various mission-focused institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, as well as eligible federal agencies and U.S. territories or possessions. Foreign institutions are not eligible to apply, and foreign components of U.S. organizations are not allowed, consistent with NIH policy limitations described in the notice.
In summary, this FOA is essentially about sustaining a high-value clinical registry that functions as the backbone for understanding islet transplantation practice and outcomes across North America. It supports the technical and analytic capacity needed to continuously gather and manage multi-center clinical data, generate regular outcome reporting, and enable research that can pinpoint the clinical factors most tied to success in islet transplantation for type 1 diabetes. For applicants, the expectation is not only to run a secure, comprehensive registry, but also to ensure the data are structured, analyzable, and actively used to advance knowledge through reports, publications, and presentations.
FAQs: RFA-DK-12-002 - The Collaborative Islet Transplantation Registry (UC4)
What is the funding opportunity RFA-DK-12-002?
RFA-DK-12-002 is a National Institutes of Health (NIH) discretionary funding opportunity to support the Collaborative Islet Transplantation Registry (CITR) using a cooperative agreement mechanism (UC4). The intent is to continue support for a centralized registry that captures and documents essentially all clinical islet transplantation activity across North America.
What is the title of this opportunity?
The opportunity is titled "The Collaborative Islet Transplantation Registry (UC4)."
What is CITR and what does it do?
The Collaborative Islet Transplantation Registry (CITR) is a North America-wide clinical registry that has operated since 2001. It is designed to systematically collect, curate, and analyze data related to clinical islet transplantation in real-world settings, creating a comprehensive picture of how the therapy is being used and how well it performs across multiple centers.
What is the overall purpose of this cooperative agreement?
The overall purpose is to maintain an ongoing, centralized resource that collects and analyzes islet transplantation data and converts those data into usable information for the research community and CITR investigators. The goal is to help the field understand outcomes, compare practices, and improve future patient care for people with type 1 diabetes who may be candidates for islet transplantation.
What kinds of activities are expected to be supported under this announcement?
The core supported activities focus on robust data collection and long-term data infrastructure. Applicants are expected to develop, operate, and maintain sophisticated databases capable of securely storing detailed clinical and procedural information related to islet transplantation, and to support analysis and reporting so the data are actively usable for research and dissemination.
Is this registry meant to be an archive only, or also usable for research?
The registry is explicitly meant to be usable, not just archival. The database environment should support analysis and reporting that enables investigators to answer evolving research questions, publish findings, and present results as the field changes over time.
What deliverables or outputs are emphasized?
A major required product is an annual report that summarizes islet transplantation outcomes and describes trends over time. The FOA also emphasizes analysis and reporting capabilities that support publications and presentations using the registry data.
What is included in the annual report?
The annual report is intended to summarize outcomes and trends over time across the region. Examples of the kinds of topics it may cover include changes in patient selection, procedural approaches, immunosuppression strategies, short- and long-term outcomes, and other measurable indicators of success or complications.
How is this registry expected to help the field?
By continually analyzing accumulated data, CITR is positioned to identify risk factors and determinants of success. These insights can guide improvements in clinical protocols, inform future trials, and support evidence-based decision-making in a therapy area where experience is distributed across many centers and practices can evolve quickly.
What funding mechanism is used?
This opportunity uses a cooperative agreement mechanism (UC4), which generally indicates substantial NIH involvement during the project period compared with a standard grant.
What is the CFDA number and NIH program area listed?
The activity category is listed under Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847).
How much funding is available under this opportunity?
The estimated total funding is $4,000,000, and the award ceiling is $530,000.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
When was the opportunity posted and what were the key dates?
The opportunity was posted on March 2, 2012. The original and current closing date was May 16, 2012. The archive date was June 16, 2012.
Is this an active funding opportunity?
No. Based on the provided dates (closing date in May 2012 and archive date in June 2012), this is a past funding opportunity. It may still be useful as a reference for the scope and expectations of the CITR program.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include various levels of government (state, county, city or township), special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status, with exclusions as specified), and for-profit organizations (including small businesses).
Are tribal entities and U.S. territories included as eligible applicants?
Yes. The announcement includes tribal entities and regional organizations, and also references eligible federal agencies and U.S. territories or possessions as eligible applicants.
Does the announcement mention specific institution types (such as minority-serving institutions)?
Yes. The announcement explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, among others.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply.
Are foreign components of U.S. organizations allowed?
No. Foreign components of U.S. organizations are not allowed, consistent with NIH policy limitations referenced in the notice.
What is the geographic scope of the registry described in the opportunity?
The registry is described as North America-wide and designed to capture essentially all clinical islet transplantation activity across the region.
What population and condition are most directly referenced as benefiting from this work?
The opportunity highlights improving future patient care for people with type 1 diabetes who may be candidates for islet transplantation.
What is the emphasis regarding data quality and standardization?
The opportunity emphasizes capturing high-quality, standardized data across sites over time and maintaining a dataset that is analyzable, reliable, and accessible for legitimate research and dissemination.
What is expected regarding security and data storage?
Applicants are expected to operate sophisticated databases that can securely store detailed clinical and procedural information related to islet transplantation.
What does the opportunity suggest about how the data should be used by investigators?
The FOA stresses that the registry should enable investigators to use the data to publish findings, present results, and answer evolving research questions, rather than merely storing information.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA DK 12 002) also looked into and applied for these:
| Funding Opportunity |
|---|
| NIDDK Short Term Education Program for Underrepresented Persons (STEP UP) (R25) Apply for RFA DK 12 005 Funding Number: RFA DK 12 005 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $158,000 |
| The Human Islet Distribution Coordinating Center (UC4) Apply for RFA DK 12 001 Funding Number: RFA DK 12 001 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $2,000,000 |
| Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21) Apply for PA 12 125 Funding Number: PA 12 125 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical Research Grants in Diabetes, and Endocrine and Metabolic Diseases (R21) Apply for PA 12 157 Funding Number: PA 12 157 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
| Translational Research to Improve Obesity and Diabetes Outcomes (R18) Apply for PAR 12 172 Funding Number: PAR 12 172 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Planning Grants for Translational Research to Improve Obesity and Diabetes Outcomes (R34) Apply for PAR 12 173 Funding Number: PAR 12 173 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Promoting Organ and Tissue Donation Among Diverse Populations (R01) Apply for RFA DK 12 006 Funding Number: RFA DK 12 006 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Limited Competition for the Continuation of the Halt Polycystic Kidney Disease Trials Data Coordinating Center (DCC) (U01) Apply for RFA DK 12 505 Funding Number: RFA DK 12 505 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of Look AHEAD (Action for Health in Diabetes) Consortium (U01) Apply for RFA DK 12 502 Funding Number: RFA DK 12 502 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Renal Function and Chronic Kidney Disease in Aging (R01) Apply for PA 12 211 Funding Number: PA 12 211 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| George M. OBrien Kidney Research Core Centers (P30) Apply for RFA DK 12 008 Funding Number: RFA DK 12 008 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $750,000 |
| Research Enhancement for NIDDK Hematology Grantees (Admin Supp) Apply for PA 12 242 Funding Number: PA 12 242 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| New Technologies for the Study of Lymphatics in the Digestive and Urinary Systems (R43/R44) Apply for PA 12 258 Funding Number: PA 12 258 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01) Apply for PAR 12 259 Funding Number: PAR 12 259 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $250,000 |
| Lymphatics in Health and Disease in the Digestive, Cardiovascular and Pulmonary Systems (R21) Apply for PAR 12 260 Funding Number: PAR 12 260 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $125,000 |
| Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) Apply for PAR 12 265 Funding Number: PAR 12 265 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Assessment, Serial Evaluation and Subsequent Sequelae of Acute Kidney Injury (ASSESS AKI) Study (U01) Apply for RFA DK 12 509 Funding Number: RFA DK 12 509 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Pilot Studies of Candidate Therapies for Chronic Kidney Disease (CKD) (U01) Apply for RFA DK 12 016 Funding Number: RFA DK 12 016 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) (U01) Apply for RFA DK 12 017 Funding Number: RFA DK 12 017 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01) Apply for RFA DK 12 508 Funding Number: RFA DK 12 508 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
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